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CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 630798: 26S proteasome regulatory subunit

There are 8 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Microtubule-severing ATPase. [EC: 3.6.4.3]
ATP + H(2)O = ADP + phosphate.
  • Another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome.
 50 A0A059MLK4 A0A074SKG4 A0A074SNR3 A0A086JCF4 A0A086K367 A0A086KF82 A0A086KUR4 A0A086L2A3 A0A086LFY7 A0A086PN24
(40 more...)
Proteasome ATPase. [EC: 3.6.4.8]
ATP + H(2)O = ADP + phosphate.
  • Belongs to the AAA-type superfamily and, like EC 3.6.4.5, is involved in channel gating and polypeptide unfolding before proteolysis in the proteasome.
  • Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome.
 41 A0A060RT82 A0A060RY37 A0A0J9SCY2 A0A0J9SFZ9 A0A0J9SYG5 A0A0J9TE79 A0A0J9TG81 A0A0J9TX79 A0A0J9TZ84 A0A0J9VJE4
(31 more...)
Adenosinetriphosphatase. [EC: 3.6.1.3]
ATP + H(2)O = ADP + phosphate.
  • Many enzymes previously listed under this number are now listed separately as EC 3.6.1.32 to EC 3.6.1.39.
  • The remaining enzymes, not separately listed on the basis of some function coupled with hydrolyzes of ATP, include enzymes dependent on Ca(2+), Mg(2+), anions, H(+) or DNA.
  • Formerly EC 3.6.1.4.
 19 A0A060TDL6 A0A0B4LIJ0 A0A0B7F615 A0A171BBF6 B4HG06 B4QSD0 D0L2B2 D3Q4J1 D5UYI6 D6Z9G0
(9 more...)
Vesicle-fusing ATPase. [EC: 3.6.4.6]
ATP + H(2)O = ADP + phosphate.
  • A large family of ATP-hydrolyzing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments.
  • They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily.
  • They include peroxin, which apparently is involved in Zellweger's syndrome.
 9 A0A0D6GMN3 A0A1N0QBQ6 A0QQS4 A1T337 A1UAG3 A4T2V8 G8S994 L8FIH2 N1M4L3
Nucleoside-triphosphate phosphatase. [EC: 3.6.1.15]
NTP + H(2)O = NDP + phosphate.
  • The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria.
  • Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD.
  • The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
 7 A0A060SX47 A0A060T4I3 A0A0L1HFP8 A0A0L1HMM4 A0A0N7Z393 A0A0P4ULY1 A0A171BBF6
Proteasome endopeptidase complex. [EC: 3.4.25.1]
Cleavage of peptide bonds with very broad specificity.
  • A 20-S protein composed of 28 subunits arranged in four rings of seven.
  • The outer rings are composed of alpha subunits, but the beta subunits forming the inner rings are responsible for peptidase activity.
  • In eukaryotic organisms there are up to seven different types of beta subunits, three of which may carry the N-terminal threonine residues that are the nucleophiles in catalysis, and show different specificities.
  • The molecule is barrel-shaped, and the active sites are on the inner surfaces.
  • Terminal apertures restrict access of substrates to the active sites.
  • Inhibited by mercurial reagents and some inhibitors of serine endopeptidases.
  • Belongs to peptidase family T1.
  • Formerly EC 3.4.22.21, EC 3.4.24.5 and EC 3.4.99.46.
 5 A0A0F4YUL4 A2QDI2 C1LMF0 C1LMF1 C1LMF2
Glycine hydroxymethyltransferase. [EC: 2.1.2.1]
5,10-methylenetetrahydrofolate + glycine + H(2)O = tetrahydrofolate + L-serine.
  • Also catalyzes the reaction of glycine with acetaldehyde to form L-threonine, and with 4-trimethylammoniobutanal to form 3-hydroxy- N(6),N(6),N(6)-trimethyl-L-lysine.
 3 A0A094CH70 A0A094GHS7 A0A094GL70
Endo-1,4-beta-xylanase. [EC: 3.2.1.8]
Endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans.
    		 1 A0A0G4N2G1
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