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CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 629735: Midasin nuclear aaa atpase

There are 18 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Dynein ATPase. [EC: 3.6.4.2]
ATP + H(2)O = ADP + phosphate.
  • A multisubunit protein complex associated with microtubules.
  • Hydrolysis of ATP provides energy for the movement of organelles (endosomes, lysosomes, mitochondria) along microtubules to the centrosome toward the microtubule's minus end.
  • It also functions in the movement of eukaryotic flagella and cilia.
  • Formerly EC 3.6.1.33.
 13 A0A077YEJ5 A0A077YEM3 A0A078KF81 A0A0Y9X2C4 A0A1C6WWR4 A0A1C6XDV5 A0A1C6XPP6 A0A1D3LEE9 A0A1D3LK38 A0A1D3LVI0
(3 more...)
Adenosinetriphosphatase. [EC: 3.6.1.3]
ATP + H(2)O = ADP + phosphate.
  • Many enzymes previously listed under this number are now listed separately as EC 3.6.1.32 to EC 3.6.1.39.
  • The remaining enzymes, not separately listed on the basis of some function coupled with hydrolyzes of ATP, include enzymes dependent on Ca(2+), Mg(2+), anions, H(+) or DNA.
  • Formerly EC 3.6.1.4.
 6 A0A0J9RAK9 A0A0R3NVM2 A8DYB0 B3MG33 B4MDY0 B5DYZ6
Cobaltochelatase. [EC: 6.6.1.2]
ATP + hydrogenobyrinic acid a,c-diamide + Co(2+) + H(2)O = ADP + phosphate + cob(II)yrinic acid a,c-diamide + H(2).
  • This enzyme, which forms part of the aerobic cobalamin biosynthesis pathway, is a type I chelatase, being heterotrimeric and ATP- dependent.
  • It comprises two components, one of which corresponds to CobN and the other is composed of two polypeptides, specified by cobS and cobT in Pseudomonas denitrificans, and named CobST.
  • Hydrogenobyrinic acid is a very poor substrate.
  • ATP can be replaced by dATP or CTP but the reaction proceeds more slowly.
  • CobN exhibits a high affinity for hydrogenobyrinic acid a,c-diamide.
  • The oligomeric protein CobST possesses at least one sulfhydryl group that is essential for ATP-binding.
  • Once the Co(2+) is inserted, the next step in the pathway ensures that the cobalt is ligated securely by reducing Co(II) to Co(I); this step is carried out by EC 1.16.8.1.
 4 B0EDU1 B7PT76 G0QWH3 L1LDQ7
Endopeptidase La. [EC: 3.4.21.53]
Hydrolysis of proteins in presence of ATP.
  • ATP hydrolysis is linked with peptide bond hydrolysis.
  • Vanadate inhibits both reactions.
  • A similar enzyme occurs in animal mitochondria.
  • Belongs to peptidase family S16.
 2 B0EDU1 B7PT76
Polyamine-transporting ATPase. [EC: 3.6.3.31]
ATP + H(2)O + polyamine(Out) = ADP + phosphate + polyamine(In).
  • A bacterial enzyme that imports putrescine and spermidine.
 2 B0EDU1 G0QWH3
Taurine-transporting ATPase. [EC: 3.6.3.36]
ATP + H(2)O + taurine(Out) = ADP + phosphate + taurine(In).
  • A bacterial enzyme that imports taurine.
 1 G0QWH3
Fe(3+)-transporting ATPase. [EC: 3.6.3.30]
ATP + H(2)O + Fe(3+)(Out) = ADP + phosphate + Fe(3+)(In).
  • A bacterial enzyme that imports ferric cations.
 1 B0EDU1
Nucleoside-triphosphate phosphatase. [EC: 3.6.1.15]
NTP + H(2)O = NDP + phosphate.
  • The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria.
  • Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD.
  • The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
 1 G0QWH3
Succinate--CoA ligase (ADP-forming). [EC: 6.2.1.5]
ATP + succinate + CoA = ADP + phosphate + succinyl-CoA.
    		 1 G0QWH3
    Arabinogalactan endo-beta-1,4-galactanase. [EC: 3.2.1.89]
    The enzyme specifically hydrolyzes (1->4)-beta-D-galactosidic linkages in type I arabinogalactans.
    • This enzyme, isolated from the bacterium Bacillus subtilis, hydrolyzes the beta(1->4) bonds found in type I plant arabinogalactans, which are a component of the primary cell walls of dicots.
    • The predominant product is a tetrasaccharide.
    • Cf. EC 3.2.1.181.
    		 1 B0EDU1
    4-hydroxybenzoyl-CoA reductase. [EC: 1.3.7.9]
    Benzoyl-CoA + oxidized ferredoxin = 4-hydroxybenzoyl-CoA + reduced ferredoxin.
    • Involved in the anaerobic pathway of phenol metabolism in bacteria.
    • A ferredoxin with two [4Fe-4S] clusters functions as the natural electron donor.
    • Formerly EC 1.3.99.20.
    		 1 G0QWH3
    Triacylglycerol lipase. [EC: 3.1.1.3]
    Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
    • The pancreatic enzyme acts only on an ester-water interface; the outer ester links are preferentially hydrolyzed.
    		 1 G0QWH3
    IMP dehydrogenase. [EC: 1.1.1.205]
    Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH.
    • The enzyme acts on the hydroxy group of the hydrated derivative of the substrate.
    • Formerly EC 1.2.1.14.
    		 1 A0A177BAV7
    Nardilysin. [EC: 3.4.24.61]
    Hydrolysis of polypeptides, preferably at -Xaa-|-Arg-Lys-, and less commonly at -Arg-|-Arg-Xaa-, in which Xaa is not Arg or Lys.
    • Unusually for a metallopeptidase, inhibited by bestatin, amastin and ethylmaleimide.
    • Belongs to peptidase family M16.
    		 1 B0EDU1
    Histone acetyltransferase. [EC: 2.3.1.48]
    Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine.
    • A group of enzymes acetylating histones.
    • Several of the enzymes can also acetylate lysines in other proteins.
    		 1 B0EDU1
    Sodium-transporting two-sector ATPase. [EC: 3.6.3.15]
    ATP + H(2)O + Na(+)(In) = ADP + phosphate + Na(+)(Out).
    • A multisubunit non-phosphorylated ATPase that is involved in the transport of ions.
    • An enzyme found in alkaliphilic bacteria that is similar to EC 3.6.3.14.
    		 1 B0EDU1
    Aspartate racemase. [EC: 5.1.1.13]
    L-aspartate = D-aspartate.
    • Also acts, at half the rate, on L-alanine.
    		 1 B0EDU1
    Type I site-specific deoxyribonuclease. [EC: 3.1.21.3]
    Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates; ATP is simultaneously hydrolyzed.
    • Large group of enzymes that have an absolute requirement for ATP (or dATP) and S-adenosyl-L-methionine.
    • They recognize specific short DNA sequences and cleave at sites remote from the recognition sequence.
    • Multifunctional proteins which also catalyze the reactions of EC 2.1.1.72 and EC 2.1.1.73, with similar site specificity.
    • Formerly EC 3.1.24.1 and EC 3.1.24.2.
    • See the REBASE database for a complete list of these enzymes: http://rebase.neb.com/rebase/
    		 1 G0QWH3
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