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CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 629331: ATP-binding cassette, sub-family E, member 1

There are 13 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Adenosinetriphosphatase. [EC: 3.6.1.3]
ATP + H(2)O = ADP + phosphate.
  • Many enzymes previously listed under this number are now listed separately as EC 3.6.1.32 to EC 3.6.1.39.
  • The remaining enzymes, not separately listed on the basis of some function coupled with hydrolyzes of ATP, include enzymes dependent on Ca(2+), Mg(2+), anions, H(+) or DNA.
  • Formerly EC 3.6.1.4.
 13 A0A060TGS9 A0A0L1HQT9 A0A171B727 B3M5W6 B3NBL0 B4HK57 B4KVN7 B4LEV7 B4N6N2 B4PFG4
(3 more...)
Sulfate-transporting ATPase. [EC: 3.6.3.25]
ATP + H(2)O + sulfate(Out) = ADP + phosphate + sulfate(In).
  • A bacterial enzyme that imports sulfate and thiosulfate anions.
 12 A0A074SUE4 A0A086JHB6 A0A086JJU3 A0A086K9Y2 A0A086LP89 A0A086PLK0 A0A086QEB0 A0A125YMA0 A0A125YMA1 A0A139XIZ8
(2 more...)
Iron-chelate-transporting ATPase. [EC: 3.6.3.34]
ATP + H(2)O + iron chelate(Out) = ADP + phosphate + iron chelate(In).
  • A bacterial enzyme that imports Fe-enterobactin, Fe-dicitrate, Fe-hydroxamate and other siderophores.
 11 A0A086JHB6 A0A086JJU3 A0A086K9Y2 A0A086LP89 A0A086PLK0 A0A086QEB0 A0A125YMA0 A0A125YMA1 A0A139XIZ8 A0A151H4Z1
(1 more...)
Phosphonate-transporting ATPase. [EC: 3.6.3.28]
ATP + H(2)O + phosphonate(Out) = ADP + phosphate + phosphonate(In).
  • A bacterial enzyme that imports phosphonate and organophosphate anions.
 2 E0VD57 M5BLW6
4-nitrophenylphosphatase. [EC: 3.1.3.41]
4-nitrophenyl phosphate + H(2)O = 4-nitrophenol + phosphate.
  • A number of other substances, including phenyl phosphate, 4-nitrophenyl sulfate, acetyl phosphate and glycerol phosphate, are not substrates.
 1 B7GAG2
Phosphoglycolate phosphatase. [EC: 3.1.3.18]
2-phosphoglycolate + H(2)O = glycolate + phosphate.
    		 1 B7GAG2
    Fe(3+)-transporting ATPase. [EC: 3.6.3.30]
    ATP + H(2)O + Fe(3+)(Out) = ADP + phosphate + Fe(3+)(In).
    • A bacterial enzyme that imports ferric cations.
    		 1 B9SQL2
    Nucleoside-triphosphate phosphatase. [EC: 3.6.1.15]
    NTP + H(2)O = NDP + phosphate.
    • The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria.
    • Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD.
    • The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
    		 1 A0A171B727
    Polyamine-transporting ATPase. [EC: 3.6.3.31]
    ATP + H(2)O + polyamine(Out) = ADP + phosphate + polyamine(In).
    • A bacterial enzyme that imports putrescine and spermidine.
    		 1 B0E8B9
    Indolepyruvate ferredoxin oxidoreductase. [EC: 1.2.7.8]
    (Indol-3-yl)pyruvate + CoA + 2 oxidized ferredoxin = S-2-(indol-3- yl)acetyl-CoA + CO(2) + 2 reduced ferredoxin + H(+).
    • Preferentially utilizes the transaminated forms of aromatic amino acids and can use phenylpyruvate and 4-hydroxyphenylpyruvate as substrates.
    • This enzyme, which is found in archaea, is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity.
    • For examples of other members of this family, see EC 1.2.7.3 and EC 1.2.7.7.
    		 1 B0E8B9
    Monosaccharide-transporting ATPase. [EC: 3.6.3.17]
    ATP + H(2)O + monosaccharide(Out) = ADP + phosphate + monosaccharide(In).
    • Family of bacterial enzymes importing ribose, xylose, arabinose, galactose and methylgalactoside.
    		 1 L0B3K1
    Nickel-transporting ATPase. [EC: 3.6.3.24]
    ATP + H(2)O + Ni(2+)(Out) = ADP + phosphate + Ni(2+)(In).
    • A bacterial enzyme that imports Ni(2+).
    		 1 B0E8B9
    Protein-tyrosine-phosphatase. [EC: 3.1.3.48]
    Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
    • Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.
    		 1 B0E8B9
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