View in Gene3D

CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 625851: Pachytene checkpoint protein 2 homolog

There are 5 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Vesicle-fusing ATPase. [EC: 3.6.4.6]
ATP + H(2)O = ADP + phosphate.
  • A large family of ATP-hydrolyzing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments.
  • They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily.
  • They include peroxin, which apparently is involved in Zellweger's syndrome.
 12 A0A074SLN9 A0A086J9S8 A0A086KEJ6 A0A086L997 A0A086M0Z5 A0A086Q886 A0A086QHP8 A0A125YQY4 A0A139Y2G9 A0A151HJB1
(2 more...)
Microtubule-severing ATPase. [EC: 3.6.4.3]
ATP + H(2)O = ADP + phosphate.
  • Another member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome.
 2 B7QA25 B9RAU0
Quinol--cytochrome-c reductase. [EC: 1.10.2.2]
Quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H(+).
  • The enzyme, often referred to as the cytochrome bc1 complex or complex III, is the third complex in the electron transport chain.
  • It is present in the mitochondria of all aerobic eukaryotes and in the inner membranes of most bacteria.
  • The mammalian enzyme contains cytochromes b-562, b-566 and C(1), and a 2-iron ferredoxin.
  • Depending on the organism and physiological conditions, the enzyme extrudes either two or four protons from the cytoplasmic to the non- cytoplasmic compartment (cf. EC 1.6.99.3).
 2 A0A0B2QCF2 A0A0B2RC59
Nucleoside-triphosphate phosphatase. [EC: 3.6.1.15]
NTP + H(2)O = NDP + phosphate.
  • The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria.
  • Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD.
  • The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
 1 A0A151TRG2
Protein S-acyltransferase. [EC: 2.3.1.225]
Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.
  • The enzyme catalyzes the posttranslational protein palmitoylation that plays a role in protein-membrane interactions, protein trafficking, and enzyme activity.
  • Palmitoylation increases the hydrophobicity of proteins or protein domains and contributes to their membrane association.
 1 A0A0L6UZ51
CATH-Gene3D is a Global Biodata Core Resource Learn more...