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CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 625027: Multidrug resistance-like ATP-binding protein

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Xenobiotic-transporting ATPase. [EC: 3.6.3.44]
ATP + H(2)O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).
  • Enzymes of Gram-positive bacteria and eukaryotic cells that export a number of drugs, with unusual specificity, covering various groups of unrelated substances, while ignoring some that are closely related structurally.
  • Several distinct enzymes may be present in a single eukaryotic cell.
  • Many of them transport glutathione conjugates with drugs.
  • Some also show some 'flippase' (EC 3.6.3.1) activity.
  • Formerly EC 3.6.3.45.
 342 A0A017ILG7 A0A023YT43 A0A024KSG6 A0A025C9X1 A0A026UGY2 A0A027TTS8 A0A028AIE2 A0A028DLY8 A0A029IC90 A0A029J0Z3
(332 more...)
Adenosinetriphosphatase. [EC: 3.6.1.3]
ATP + H(2)O = ADP + phosphate.
  • Many enzymes previously listed under this number are now listed separately as EC 3.6.1.32 to EC 3.6.1.39.
  • The remaining enzymes, not separately listed on the basis of some function coupled with hydrolyzes of ATP, include enzymes dependent on Ca(2+), Mg(2+), anions, H(+) or DNA.
  • Formerly EC 3.6.1.4.
 23 A0A085AEI5 A0A085G776 A0A085GI48 A0A085GQD1 A0A085H5V2 A0A085HMI0 A0A085HXR3 A0A0A6YDU8 A0A0H2QGH2 A0A0M2NA70
(13 more...)
Nucleoside-triphosphate phosphatase. [EC: 3.6.1.15]
NTP + H(2)O = NDP + phosphate.
  • The enzyme is found in eukaryotes and thermophilic bacteria, but appears to be absent from mesophilic bacteria.
  • Also hydrolyzes nucleoside diphosphates, thiamine diphosphate and FAD.
  • The enzyme from the plant Pisum sativum (garden pea) is regulated by calmodulin.
 20 A0A085AEI5 A0A085G776 A0A085GI48 A0A085GQD1 A0A085H5V2 A0A085HMI0 A0A085HXR3 A0A0H2QGH2 A0A0M2NA70 A0A0N0ZAY8
(10 more...)
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