The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 620704: ATP-binding cassette sub-family G member 8

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q9H221 (/IPI)
Sterol transporter activity GO:0015248
Enables the directed movement of sterols into, out of or within a cell, or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
1 P58428 (/IMP)
Cholesterol transporter activity GO:0017127
Enables the directed movement of cholesterol into, out of or within a cell, or between cells. Cholesterol is the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
1 P58428 (/TAS)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 Q9H221 (/IPI)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 Q9DBM0 (/ISO)

There are 22 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Sterol transport GO:0015918
The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
2 P58428 (/TAS) Q9H221 (/TAS)
Intestinal cholesterol absorption GO:0030299
Uptake of cholesterol into the blood by absorption from the small intestine.
2 Q9DBM0 (/IC) Q9H221 (/IC)
Cholesterol homeostasis GO:0042632
Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
2 Q9DBM0 (/IMP) Q9H221 (/IMP)
Response to nutrient GO:0007584
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
1 P58428 (/IEP)
Excretion GO:0007588
The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.
1 Q9H221 (/IGI)
Excretion GO:0007588
The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.
1 Q9DBM0 (/IMP)
Excretion GO:0007588
The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.
1 Q9DBM0 (/ISO)
Negative regulation of intestinal phytosterol absorption GO:0010949
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of phytosterols into the blood by absorption from the small intestine.
1 Q9H221 (/IMP)
Negative regulation of intestinal phytosterol absorption GO:0010949
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of phytosterols into the blood by absorption from the small intestine.
1 Q9DBM0 (/ISO)
Phospholipid transport GO:0015914
The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester.
1 Q9DBM0 (/IMP)
Sterol transport GO:0015918
The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
1 Q9DBM0 (/IMP)
Regulation of intestinal cholesterol absorption GO:0030300
Any process that modulates the frequency, rate or extent of absorption of cholesterol into the blood, and the exclusion of other sterols from absorption.
1 P58428 (/TAS)
Cholesterol transport GO:0030301
The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
1 P58428 (/TAS)
Cholesterol efflux GO:0033344
The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.
1 Q9H221 (/IGI)
Cholesterol efflux GO:0033344
The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.
1 Q9DBM0 (/IMP)
Cholesterol efflux GO:0033344
The directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.
1 Q9DBM0 (/ISO)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 P58428 (/IEP)
Cholesterol homeostasis GO:0042632
Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell.
1 Q9DBM0 (/ISO)
Negative regulation of intestinal cholesterol absorption GO:0045796
Any process that stops, prevents, or reduces the frequency, rate or extent of uptake of cholesterol into the blood by absorption from the intestine.
1 Q9H221 (/IMP)
Negative regulation of intestinal cholesterol absorption GO:0045796
Any process that stops, prevents, or reduces the frequency, rate or extent of uptake of cholesterol into the blood by absorption from the intestine.
1 Q9DBM0 (/ISO)
Transmembrane transport GO:0055085
The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other
1 Q9H221 (/TAS)
Sterol homeostasis GO:0055092
Any process involved in the maintenance of an internal steady state of sterol within an organism or cell.
1 Q9DBM0 (/IMP)

There are 8 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
2 Q9DBM0 (/IMP) Q9H221 (/IMP)
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
2 Q9DBM0 (/IDA) Q9H221 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q9H221 (/TAS)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 Q9DBM0 (/ISO)
ATP-binding cassette (ABC) transporter complex GO:0043190
A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter.
1 Q9H221 (/IDA)
ATP-binding cassette (ABC) transporter complex GO:0043190
A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter.
1 Q9DBM0 (/ISO)
ATP-binding cassette (ABC) transporter complex GO:0043190
A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter.
1 P58428 (/TAS)
Receptor complex GO:0043235
Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 Q9DBM0 (/ISO)
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