The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 620196: Dynamin-like 120 kDa protein

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
5 A0A0B4LF33 (/ISM) A0A0B4LFB8 (/ISM) A0A0B4LGF5 (/ISM) A1Z9N0 (/ISM) Q95U20 (/ISM)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
2 O60313 (/TAS) P58281 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 O60313 (/IPI) P58281 (/IPI)
Magnesium ion binding GO:0000287
Interacting selectively and non-covalently with magnesium (Mg) ions.
1 O60313 (/NAS)
GTPase activity GO:0003924
Catalysis of the reaction: GTP + H2O = GDP + phosphate.
1 O93248 (/IDA)

There are 48 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion organization GO:0007005
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
7 A0A0B4LF33 (/IMP) A0A0B4LFB8 (/IMP) A0A0B4LGF5 (/IMP) A1Z9N0 (/IMP) O60313 (/IMP) Q18965 (/IMP) Q95U20 (/IMP)
Mitochondrial fusion GO:0008053
Merging of two or more mitochondria within a cell to form a single compartment.
7 A0A0B4LF33 (/IMP) A0A0B4LFB8 (/IMP) A0A0B4LGF5 (/IMP) A1Z9N0 (/IMP) O60313 (/IMP) Q18965 (/IMP) Q95U20 (/IMP)
Mitochondrion morphogenesis GO:0070584
The process in which the anatomical structures of a mitochondrion are generated and organized.
7 A0A0B4LF33 (/IMP) A0A0B4LFB8 (/IMP) A0A0B4LGF5 (/IMP) A1Z9N0 (/IMP) Q2TA68 (/IMP) Q5U3A7 (/IMP) Q95U20 (/IMP)
Positive regulation of mitochondrial fusion GO:0010636
Any process that increases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment.
6 A0A0B4LF33 (/IMP) A0A0B4LFB8 (/IMP) A0A0B4LGF5 (/IMP) A1Z9N0 (/IMP) Q2TA68 (/IMP) Q95U20 (/IMP)
Compound eye morphogenesis GO:0001745
The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.
5 A0A0B4LF33 (/IMP) A0A0B4LFB8 (/IMP) A0A0B4LGF5 (/IMP) A1Z9N0 (/IMP) Q95U20 (/IMP)
Phototransduction GO:0007602
The sequence of reactions within a cell required to convert absorbed photons into a molecular signal.
5 A0A0B4LF33 (/IMP) A0A0B4LFB8 (/IMP) A0A0B4LGF5 (/IMP) A1Z9N0 (/IMP) Q95U20 (/IMP)
Inner mitochondrial membrane organization GO:0007007
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial inner membrane.
4 O93248 (/ISS) P58281 (/ISS) Q2TA68 (/ISS) Q80TX7 (/ISS)
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
4 O93248 (/ISS) P58281 (/ISS) Q2TA68 (/ISS) Q80TX7 (/ISS)
Mitochondrial genome maintenance GO:0000002
The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome.
3 P58281 (/ISS) Q2TA68 (/ISS) Q5RAM3 (/ISS)
Mitochondrion organization GO:0007005
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
2 P58281 (/IDA) Q2TA68 (/IDA)
Mitochondrion organization GO:0007005
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
2 O60313 (/NAS) P58281 (/NAS)
Mitochondrial fusion GO:0008053
Merging of two or more mitochondria within a cell to form a single compartment.
2 O60313 (/IDA) P58281 (/IDA)
Negative regulation of release of cytochrome c from mitochondria GO:0090201
Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
2 O60313 (/IMP) P58281 (/IMP)
Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902236
Any process that stops, prevents or reduces the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway.
2 A1Z9N0 (/ISS) Q2TA68 (/ISS)
Mitochondrial genome maintenance GO:0000002
The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome.
1 O60313 (/IMP)
Mitochondrial genome maintenance GO:0000002
The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome.
1 P58281 (/ISO)
Mitochondrial fission GO:0000266
The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.
1 O60313 (/TAS)
Response to superoxide GO:0000303
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion.
1 Q18965 (/IMP)
Neural tube closure GO:0001843
The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline.
1 P58281 (/IMP)
Nematode larval development GO:0002119
The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.
1 Q18965 (/IGI)
Mitochondrion organization GO:0007005
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.
1 P58281 (/ISO)
Inner mitochondrial membrane organization GO:0007007
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial inner membrane.
1 O60313 (/IDA)
Inner mitochondrial membrane organization GO:0007007
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial inner membrane.
1 P58281 (/ISO)
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
1 Q2TA68 (/IEP)
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
1 O60313 (/IMP)
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
1 P58281 (/ISO)
Mitochondrial fusion GO:0008053
Merging of two or more mitochondria within a cell to form a single compartment.
1 P58281 (/ISO)
Mitochondrial fusion GO:0008053
Merging of two or more mitochondria within a cell to form a single compartment.
1 Q2TA68 (/ISS)
Mitochondrial fusion GO:0008053
Merging of two or more mitochondria within a cell to form a single compartment.
1 O60313 (/TAS)
Positive regulation of neuron maturation GO:0014042
Any process that activates or increases the frequency, rate or extent of neuron maturation.
1 Q2TA68 (/IMP)
Axonal transport of mitochondrion GO:0019896
The directed movement of mitochondria along microtubules in nerve cell axons.
1 O60313 (/TAS)
Multicellular organism growth GO:0035264
The increase in size or mass of an entire multicellular organism, as opposed to cell growth.
1 Q18965 (/IMP)
Regulation of multicellular organism growth GO:0040014
Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.
1 Q18965 (/IGI)
Regulation of multicellular organism growth GO:0040014
Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.
1 Q18965 (/IMP)
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
1 O60313 (/TAS)
Chordate embryonic development GO:0043009
The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching.
1 Q5U3A7 (/IMP)
Intracellular distribution of mitochondria GO:0048312
Any process that establishes the spatial arrangement of mitochondria within the cell.
1 Q2TA68 (/IMP)
Positive regulation of dendritic spine morphogenesis GO:0061003
Any process that increases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
1 Q2TA68 (/IMP)
Negative regulation of release of cytochrome c from mitochondria GO:0090201
Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
1 P58281 (/ISO)
Negative regulation of release of cytochrome c from mitochondria GO:0090201
Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.
1 Q2TA68 (/ISS)
Cellular senescence GO:0090398
A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest.
1 O60313 (/IDA)
Cellular senescence GO:0090398
A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest.
1 P58281 (/ISO)
Cellular senescence GO:0090398
A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest.
1 Q2TA68 (/ISS)
Positive regulation of dendrite development GO:1900006
Any process that activates or increases the frequency, rate or extent of dendrite development.
1 Q2TA68 (/IMP)
Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902236
Any process that stops, prevents or reduces the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway.
1 O60313 (/IGI)
Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902236
Any process that stops, prevents or reduces the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway.
1 P58281 (/IMP)
Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway GO:1902236
Any process that stops, prevents or reduces the frequency, rate or extent of an endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway.
1 P58281 (/ISO)
Negative regulation of intrinsic apoptotic signaling pathway GO:2001243
Any process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway.
1 P58281 (/IMP)

There are 26 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
13 A0A0B4LF33 (/IDA) A0A0B4LFB8 (/IDA) A0A0B4LGF5 (/IDA) A1Z9N0 (/IDA) E5KLJ5 (/IDA) E5KLJ6 (/IDA) E5KLJ7 (/IDA) E5KLJ9 (/IDA) E5KLK1 (/IDA) O60313 (/IDA)
(3 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
6 E5KLJ5 (/IDA) E5KLJ6 (/IDA) E5KLJ7 (/IDA) E5KLJ9 (/IDA) E5KLK1 (/IDA) O60313 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
6 E5KLJ5 (/IDA) E5KLJ6 (/IDA) E5KLJ7 (/IDA) E5KLJ9 (/IDA) E5KLK1 (/IDA) O60313 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
5 A0A0B4LF33 (/ISS) A0A0B4LFB8 (/ISS) A0A0B4LGF5 (/ISS) A1Z9N0 (/ISS) Q95U20 (/ISS)
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
4 O93248 (/ISS) P58281 (/ISS) Q2TA68 (/ISS) Q80TX7 (/ISS)
Mitochondrial intermembrane space GO:0005758
The region between the inner and outer lipid bilayers of the mitochondrial envelope.
4 O60313 (/ISS) O93248 (/ISS) Q2TA68 (/ISS) Q80TX7 (/ISS)
Mitochondrial crista GO:0030061
Any of the inward folds of the mitochondrial inner membrane. Their number, extent, and shape differ in mitochondria from different tissues and organisms. They appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found. Their shape can vary with the respiratory state of the mitochondria.
4 O93248 (/ISS) P58281 (/ISS) Q2TA68 (/ISS) Q80TX7 (/ISS)
Dendrite GO:0030425
A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
4 O60313 (/ISS) O93248 (/ISS) Q2TA68 (/ISS) Q80TX7 (/ISS)
Mitochondrial intermembrane space GO:0005758
The region between the inner and outer lipid bilayers of the mitochondrial envelope.
2 O60313 (/IDA) P58281 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 P58281 (/ISO)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 P58281 (/ISO)
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
1 O60313 (/IDA)
Mitochondrial outer membrane GO:0005741
The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope.
1 P58281 (/ISO)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 P58281 (/IDA)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 P58281 (/IMP)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 O60313 (/ISS)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 O60313 (/NAS)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 O60313 (/TAS)
Mitochondrial intermembrane space GO:0005758
The region between the inner and outer lipid bilayers of the mitochondrial envelope.
1 P58281 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 P58281 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 O60313 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P58281 (/ISO)
Mitochondrial crista GO:0030061
Any of the inward folds of the mitochondrial inner membrane. Their number, extent, and shape differ in mitochondria from different tissues and organisms. They appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found. Their shape can vary with the respiratory state of the mitochondria.
1 O60313 (/IDA)
Mitochondrial crista GO:0030061
Any of the inward folds of the mitochondrial inner membrane. Their number, extent, and shape differ in mitochondria from different tissues and organisms. They appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found. Their shape can vary with the respiratory state of the mitochondria.
1 P58281 (/ISO)
Dendrite GO:0030425
A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 P58281 (/IDA)
Extrinsic component of mitochondrial inner membrane GO:0031314
The component of mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
1 Q2TA68 (/IDA)
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