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CATH Superfamily 3.40.50.300

P-loop containing nucleotide triphosphate hydrolases

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
P-loop containing nucleotide triphosphate hydrolases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 616411: Endonuclease R Type I restriction enzyme

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Type I site-specific deoxyribonuclease. [EC: 3.1.21.3]
Endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5'-phosphates; ATP is simultaneously hydrolyzed.
  • Large group of enzymes that have an absolute requirement for ATP (or dATP) and S-adenosyl-L-methionine.
  • They recognize specific short DNA sequences and cleave at sites remote from the recognition sequence.
  • Multifunctional proteins which also catalyze the reactions of EC 2.1.1.72 and EC 2.1.1.73, with similar site specificity.
  • Formerly EC 3.1.24.1 and EC 3.1.24.2.
  • See the REBASE database for a complete list of these enzymes: http://rebase.neb.com/rebase/
 54 A0A028DNP1 A0A029H9M0 A0A029IEZ5 A0A070UQV3 A0A074ILT4 A0A085G8D0 A0A085ICA7 A0A0A8KQT6 A0A0E0VEV3 A0A0E0Y7W3
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