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CATH Superfamily 3.40.50.1820

Alpha/Beta hydrolase fold, catalytic domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 115757: Phospholipase/Carboxylesterase family protein

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Pimeloyl-[acyl-carrier protein] methyl ester esterase. [EC: 3.1.1.85]
Pimeloyl-[acyl-carrier protein] methyl ester + H(2)O = pimeloyl-[acyl- carrier protein] + methanol.
  • Involved in biotin biosynthesis in Gram-negative bacteria.
  • The enzyme exhibits carboxylesterase activity, particularly toward substrates with short acyl chains.
  • Even though the enzyme can interact with coenzyme A thioesters, the in vivo role of the enzyme is to hydrolyze the methyl ester of pimeloyl-[acyl carrier protein], terminating the part of the biotin biosynthesis pathway that is catalyzed by the fatty acid elongation enzymes.
 18 A0A023PAZ7 A0A0B6BUF1 A0A0E0W6R6 A0A0E8TDT7 A0A0K6J2L6 A0A0K6KPC2 A0A0K6MEA9 A0A0T8WEJ3 A0A0T8XFB2 A0A0U0E0Y3
(8 more...)
Arylesterase. [EC: 3.1.1.2]
A phenyl acetate + H(2)O = a phenol + acetate.
  • Acts on many phenolic esters.
  • It is likely that the three forms of human paraoxonase are lactonases rather than aromatic esterases.
  • The natural substrates of the paraoxonases are lactones, with (+-)-5- hydroxy-6E,8Z,11Z,4Z-eicostetraenoic-acid 1,5-lactone being the best substrate.
 13 A0A0F6JG07 A0A0G4CVU5 A0A0J7GLA0 A0A0T8I4K0 B7HAY9 J8I5K2 J8JQZ2 J8MRD0 J8QTZ9 J8YLH4
(3 more...)
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