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CATH Superfamily 3.40.50.1820

Alpha/Beta hydrolase fold, catalytic domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 115398: Hormone-sensitive lipase (S09 family)

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Monoterpene epsilon-lactone hydrolase. [EC: 3.1.1.83]
Isoprop(en)ylmethyloxepan-2-one + H(2)O = 6-hydroxyisoprop(en)ylmethylhexanoate.
  • Catalyzes the ring opening of epsilon-lactones which are formed during degradation of dihydrocarveol by the Gram-positive bacterium Rhodococcus erythropolis DCL14.
  • Also acts on ethyl caproate, indicating that it is an esterase with a preference for lactones (internal cyclic esters).
  • Not stereoselective.
 18 A0A009S0S3 A0A062DKK9 A0A062F9H3 A0A062G7V0 A0A062IEM2 A0A086HVT4 A0A137Y2B7 A0A150HWS2 A0A150I2G7 A0A1C4HNI6
(8 more...)
Hormone-sensitive lipase. [EC: 3.1.1.79]
(1) Diacylglycerol + H(2)O = monoacylglycerol + a carboxylate. (2) Triacylglycerol + H(2)O = diacylglycerol + a carboxylate. (3) Monoacylglycerol + H(2)O = glycerol + a carboxylate.
  • This enzyme is a serine hydrolase.
  • Compared with other lipases, hormone-sensitive lipase has a uniquely broad substrate specificity.
  • It hydrolyzes all acylglycerols (triacylglycerol, diacylglycerol and monoacylglycerol) as well as cholesteryl esters, steroid fatty acid esters, retinyl esters and p-nitrophenyl esters.
  • It exhibits a preference for the 1- or 3-ester bond of its acylglycerol substrate compared with the 2-ester bond.
  • The enzyme shows little preference for the fatty acids in the triacylglycerol, although there is some increase in activity with decreasing chain length.
  • The enzyme activity is increased in response to hormones that elevate intracellular levels of cAMP.
 8 A0A061HW32 M2X230 P15304 P16386 P54310 Q05469 Q68J42 Q9R101
Carboxylesterase. [EC: 3.1.1.1]
A carboxylic ester + H(2)O = an alcohol + a carboxylate.
  • Wide specificity; also hydrolyzes vitamin A esters.
  • The enzymes from microsomes also catalyze the reactions of EC 3.1.1.2, EC 3.1.1.5, EC 3.1.1.6, EC 3.1.1.23, EC 3.1.1.28, EC 3.1.2.2, EC 3.5.1.4, and EC 3.5.1.13.
  • Formerly EC 3.1.1.12.
 3 N9LD50 N9R6M5 X2FE78
Triacylglycerol lipase. [EC: 3.1.1.3]
Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
  • The pancreatic enzyme acts only on an ester-water interface; the outer ester links are preferentially hydrolyzed.
 1 Q7JR83
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