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CATH Superfamily 3.30.360.10

Dihydrodipicolinate Reductase; domain 2

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Dihydrodipicolinate Reductase; domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 24409: N-acetyl-gamma-glutamyl-phosphate reductase 2

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
N-acetyl-gamma-glutamyl-phosphate reductase. [EC: 1.2.1.38]
N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = N-acetyl-5- glutamyl phosphate + NADPH.
    		 2162 A0A011NDJ9 A0A011TB13 A0A011UAM8 A0A011VRA1 A0A013XVD4 A0A014QEE5 A0A016QN71 A0A016XCU0 A0A021X825 A0A022G4D4
    (2152 more...)
    Acetylglutamate kinase. [EC: 2.7.2.8]
    ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate.
      		 17 A0A060T9H6 A0A0B0DDV4 A0A0F8B149 A0A0L1HV70 A0A0P4U9K7 A2R068 A6ZR23 B3LRI6 B5VHJ9 C7GRQ1
      (7 more...)
      Nicotinate-nucleotide diphosphorylase (carboxylating). [EC: 2.4.2.19]
      Beta-nicotinate D-ribonucleotide + diphosphate + CO(2) = pyridine-2,3- dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate.
      • The reaction is catalyzed in the opposite direction.
      • Since quinolinate is synthesized from L-tryptophan in eukaryotes, but from L-aspartate in some prokaryotes, this is the first NAD(+) biosynthesis enzyme shared by both eukaryotes and prokaryotes.
      		 1 A0A0P4U9K7
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