The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Immunoglobulins
".
FunFam 74643: Carcinoembryonic antigen-related cell adhesion mol...
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 10 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
|
1 | P13688 (/IPI) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | P13688 (/IPI) |
|
Bile acid transmembrane transporter activity GO:0015125
Enables the transfer of bile acid from one side of the membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.
|
1 | P13688 (/ISS) |
|
Kinase binding GO:0019900
Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group.
|
1 | P13688 (/IPI) |
|
Protein phosphatase binding GO:0019903
Interacting selectively and non-covalently with any protein phosphatase.
|
1 | P13688 (/IPI) |
|
Filamin binding GO:0031005
Interacting selectively and non-covalently with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain.
|
1 | P13688 (/IPI) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | P13688 (/IMP) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | P13688 (/ISS) |
|
Protein dimerization activity GO:0046983
The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits.
|
1 | P13688 (/ISS) |
|
Protein tyrosine kinase binding GO:1990782
Interacting selectively and non-covalently with protein tyrosine kinase.
|
1 | P13688 (/IPI) |
There are 40 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Angiogenesis GO:0001525
Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.
|
1 | P13688 (/NAS) |
|
Regulation of cell growth GO:0001558
Any process that modulates the frequency, rate, extent or direction of cell growth.
|
1 | P13688 (/ISS) |
|
Blood vessel development GO:0001568
The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.
|
1 | P13688 (/ISS) |
|
Negative regulation of T cell mediated cytotoxicity GO:0001915
Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity.
|
1 | P13688 (/IDA) |
|
Negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002859
Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target.
|
1 | P13688 (/IMP) |
|
Negative regulation of protein kinase activity GO:0006469
Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.
|
1 | P13688 (/ISS) |
|
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
|
1 | P13688 (/ISS) |
|
Homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156
The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
|
1 | P13688 (/ISS) |
|
Homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156
The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
|
1 | P13688 (/NAS) |
|
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | P13688 (/NAS) |
|
Regulation of endothelial cell migration GO:0010594
Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
|
1 | P13688 (/ISS) |
|
Regulation of phosphatidylinositol 3-kinase signaling GO:0014066
Any process that modulates the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
|
1 | P13688 (/ISS) |
|
Bile acid and bile salt transport GO:0015721
The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
1 | P13688 (/ISS) |
|
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
|
1 | P13688 (/NAS) |
|
Regulation of cell migration GO:0030334
Any process that modulates the frequency, rate or extent of cell migration.
|
1 | P13688 (/IDA) |
|
Negative regulation of granulocyte differentiation GO:0030853
Any process that stops, prevents, or reduces the frequency, rate or extent of granulocyte differentiation.
|
1 | P13688 (/ISS) |
|
Negative regulation of interleukin-1 production GO:0032692
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 production.
|
1 | P13688 (/ISS) |
|
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
|
1 | P13688 (/ISS) |
|
Common myeloid progenitor cell proliferation GO:0035726
The multiplication or reproduction of common myeloid progenitor cells, resulting in the expansion of a cell population. A common myeloid progenitor cell is a progenitor cell committed to the myeloid lineage.
|
1 | P13688 (/ISS) |
|
Insulin receptor internalization GO:0038016
A receptor-mediated endocytosis process that results in the movement of an insulin receptor from the plasma membrane to the inside of the cell.
|
1 | P13688 (/ISS) |
|
Granulocyte colony-stimulating factor signaling pathway GO:0038158
A series of molecular signals initiated by the binding of the cytokine granulocyte colony-stimulating factor (G-CSF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. G-CSF binds to the receptor (CSF3R).
|
1 | P13688 (/ISS) |
|
Regulation of epidermal growth factor receptor signaling pathway GO:0042058
Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.
|
1 | P13688 (/ISS) |
|
Negative regulation of vascular permeability GO:0043116
Any process that reduces the extent to which blood vessels can be pervaded by fluid.
|
1 | P13688 (/ISS) |
|
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
|
1 | P13688 (/TAS) |
|
Negative regulation of cytotoxic T cell degranulation GO:0043318
Any process that stops, prevents, or reduces the rate of cytotoxic T cell degranulation.
|
1 | P13688 (/IDA) |
|
Wound healing, spreading of cells GO:0044319
The migration of a cell along or through a wound gap that contributes to the reestablishment of a continuous surface.
|
1 | P13688 (/IDA) |
|
Regulation of endothelial cell differentiation GO:0045601
Any process that modulates the frequency, rate or extent of endothelial cell differentiation.
|
1 | P13688 (/ISS) |
|
Negative regulation of fatty acid biosynthetic process GO:0045717
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids.
|
1 | P13688 (/ISS) |
|
Negative regulation of T cell receptor signaling pathway GO:0050860
Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell.
|
1 | P13688 (/IDA) |
|
Leukocyte migration GO:0050900
The movement of a leukocyte within or between different tissues and organs of the body.
|
1 | P13688 (/TAS) |
|
Negative regulation of lipid biosynthetic process GO:0051055
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids.
|
1 | P13688 (/ISS) |
|
Regulation of blood vessel remodeling GO:0060312
Any process that modulates the rate, frequency or extent of blood vessel remodeling, the reorganization or renovation of existing blood vessels.
|
1 | P13688 (/ISS) |
|
Regulation of ERK1 and ERK2 cascade GO:0070372
Any process that modulates the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
|
1 | P13688 (/ISS) |
|
Negative regulation of platelet aggregation GO:0090331
Any process that decreases the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.
|
1 | P13688 (/ISS) |
|
Cell-cell adhesion via plasma-membrane adhesion molecules GO:0098742
The attachment of one cell to another cell via adhesion molecules that are at least partially embedded in the plasma membrane.
|
1 | P13688 (/ISS) |
|
Insulin catabolic process GO:1901143
The chemical reactions and pathways resulting in the breakdown of insulin.
|
1 | P13688 (/ISS) |
|
Regulation of homophilic cell adhesion GO:1903385
Any process that modulates the frequency, rate or extent of homophilic cell adhesion.
|
1 | P13688 (/ISS) |
|
Regulation of sprouting angiogenesis GO:1903670
Any process that modulates the frequency, rate or extent of sprouting angiogenesis.
|
1 | P13688 (/ISS) |
|
Negative regulation of hepatocyte proliferation GO:2000346
Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte proliferation.
|
1 | P13688 (/ISS) |
|
Positive regulation of vasculogenesis GO:2001214
Any process that activates or increases the frequency, rate or extent of vasculogenesis.
|
1 | P13688 (/ISS) |
There are 17 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | P13688 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | P13688 (/TAS) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | P13688 (/NAS) |
|
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
|
1 | P13688 (/IDA) |
|
Adherens junction GO:0005912
A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.
|
1 | P13688 (/ISS) |
|
Basal plasma membrane GO:0009925
The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis.
|
1 | P13688 (/ISS) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
1 | P13688 (/IDA) |
|
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
1 | P13688 (/ISS) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | P13688 (/TAS) |
|
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | P13688 (/IDA) |
|
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
|
1 | P13688 (/ISS) |
|
Lateral plasma membrane GO:0016328
The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells.
|
1 | P13688 (/ISS) |
|
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
|
1 | P13688 (/IDA) |
|
Cell junction GO:0030054
A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix.
|
1 | P13688 (/ISS) |
|
Specific granule membrane GO:0035579
The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
|
1 | P13688 (/TAS) |
|
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | P13688 (/IDA) |
|
Tertiary granule membrane GO:0070821
The lipid bilayer surrounding a tertiary granule.
|
1 | P13688 (/TAS) |
