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CATH Superfamily 2.60.40.10

Immunoglobulins

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Immunoglobulins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 135691: Glycogen operon protein GlgX homolog

There are 8 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Isoamylase. [EC: 3.2.1.68]
Hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen, amylopectin and their beta-limit dextrins.
  • Also readily hydrolyzes amylopectin.
  • Differs from EC 3.2.1.41 and EC 3.2.1.142 by its inability to hydrolyze pullulan, and by limited action on alpha-limit dextrins.
  • Maltose is the smallest sugar it can release from an alpha-(1->6)- linkage.
 254 A0A076JGJ7 A0A076JGJ7 A0A086ZD86 A0A086ZD86 A0A086ZNY3 A0A086ZNY3 A0A087ACK3 A0A087ACK3 A0A087AEC2 A0A087AEC2
(244 more...)
4-alpha-glucanotransferase. [EC: 2.4.1.25]
Transfers a segment of a (1->4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1->4)-alpha-D-glucan.
  • An enzymic activity of this nature forms part of the mammalian and Saccharomyces cerevisiae glycogen branching system (see EC 3.2.1.33).
  • Formerly EC 2.4.1.3.
 18 A0A037UW98 A0A037UW98 A0A0G3ER12 A0A0G3ER12 A0A1B4K7K6 A0A1B4K7K6 A0L7T0 A0L7T0 E3I3Q7 E3I3Q7
(8 more...)
Pullulanase. [EC: 3.2.1.41]
Hydrolysis of (1->6)-alpha-D-glucosidic linkages in pullulan, amylopectin and glycogen, and in the alpha- and beta-limit dextrins of amylopectin and glycogen.
  • Different from EC 3.2.1.142 in its action on glycogen, and its rate of hydrolysis of limit dextrins.
  • Its action on amylopectin is complete.
  • Maltose is the smallest sugar that it can release from an alpha- (1->6)-linkage.
  • Formerly EC 3.2.1.69.
 10 A0A110LD12 A0A110LD12 A1K6F6 A1K6F6 C9YB64 C9YB64 I9W2V9 I9W2V9 Q0K0X7 Q0K0X7
Glucose-1-phosphate adenylyltransferase. [EC: 2.7.7.27]
ATP + alpha-D-glucose 1-phosphate = diphosphate + ADP-glucose.
    		 6 A0A0E1SQJ4 A0A0E1SQJ4 A0A0H3PEU7 A0A0H3PEU7 A4N0C7 A4N0C7
    1,4-alpha-glucan branching enzyme. [EC: 2.4.1.18]
    Transfers a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.
    • Converts amylose into amylopectin.
    • The description (official name) requires a qualification depending on the product, glycogen or amylopectin, e.g. glycogen branching enzyme, amylopectin branching enzyme.
    • The latter has frequently been termed Q-enzyme.
    		 6 A4NYI0 A4NYI0 A5UEJ3 A5UEJ3 D2QA01 D2QA01
    Phosphoribosylformylglycinamidine synthase. [EC: 6.3.5.3]
    ATP + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + H(2)O = ADP + phosphate + 2-(formamido)-N(1)-(5-phospho-D- ribosyl)acetamidine + L-glutamate.
      		 4 A0A073KRM5 A0A073KRM5 A0KZE0 A0KZE0
      Amylo-alpha-1,6-glucosidase. [EC: 3.2.1.33]
      Hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin.
      • This enzyme hydrolyzes an unsubstituted glucose unit linked by an alpha(1->6) bond to an alpha(1->4) glucose chain.
      • The enzyme activity found in mammals and Saccharomyces cerevisiae is in a polypeptide chain containing two active centers.
      • The other activity is similar to that of EC 2.4.1.25, which acts on the glycogen phosphorylase limit dextrin chains to expose the single glucose residues, which the 6-alpha-glucosidase activity can then hydrolyze.
      • Together, these two activities constitute the glycogen debranching system.
      		 4 A0A179RJB0 A0A179RJB0 Q88FN4 Q88FN4
      Glycogen phosphorylase. [EC: 2.4.1.1]
      ((1->4)-alpha-D-glucosyl)(n) + phosphate = ((1->4)-alpha-D-glucosyl)(n-1) + alpha-D-glucose 1-phosphate.
      • This entry covers several enzymes from different sources that act in vivo on different forms of (1->4)-alpha-D-glucans.
      • Some of these enzymes catalyze the first step in the degradation of large branched glycan polymers - the phosphorolytic cleavage of alpha-1,4-glucosidic bonds from the non-reducing ends of linear poly(1->4)-alpha-D-glucosyl chains within the polymers.
      • The enzyme stops when it reaches the fourth residue away from an alpha-1,6 branching point, leaving a highly branched core known as a limit dextrin.
      • The description (accepted name) of the enzyme should be modified for each specific instance by substituting 'glycogen' with the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, etc.
      		 2 A0A0A2W0I9 A0A0A2W0I9
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