The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Immunoglobulins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 135361: Neuregulin 1 isoform HRG-gamma

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 24 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
10 A0A140LHG5 (/IPI) A0A140LHN1 (/IPI) A0A140LHZ9 (/IPI) A0A140LIJ3 (/IPI) A0A140LIK5 (/IPI) A0A140LIP8 (/IPI) A0A140LJ88 (/IPI) A0A140LJC1 (/IPI) Q02297 (/IPI) Q6DR98 (/IPI)
Transcription cofactor activity GO:0003712
Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery.
9 A0A140LHG5 (/ISO) A0A140LHN1 (/ISO) A0A140LHZ9 (/ISO) A0A140LIJ3 (/ISO) A0A140LIK5 (/ISO) A0A140LIP8 (/ISO) A0A140LJ88 (/ISO) A0A140LJC1 (/ISO) Q6DR98 (/ISO)
ErbB-2 class receptor binding GO:0005176
Interacting selectively and non-covalently with the protein-tyrosine kinase receptor Neu/ErbB-2/HER2.
9 A0A140LHG5 (/IDA) A0A140LHN1 (/IDA) A0A140LHZ9 (/IDA) A0A140LIJ3 (/IDA) A0A140LIK5 (/IDA) A0A140LIP8 (/IDA) A0A140LJ88 (/IDA) A0A140LJC1 (/IDA) Q6DR98 (/IDA)
ErbB-2 class receptor binding GO:0005176
Interacting selectively and non-covalently with the protein-tyrosine kinase receptor Neu/ErbB-2/HER2.
9 A0A140LHG5 (/IGI) A0A140LHN1 (/IGI) A0A140LHZ9 (/IGI) A0A140LIJ3 (/IGI) A0A140LIK5 (/IGI) A0A140LIP8 (/IGI) A0A140LJ88 (/IGI) A0A140LJC1 (/IGI) Q6DR98 (/IGI)
Receptor tyrosine kinase binding GO:0030971
Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.
9 A0A140LHG5 (/ISO) A0A140LHN1 (/ISO) A0A140LHZ9 (/ISO) A0A140LIJ3 (/ISO) A0A140LIK5 (/ISO) A0A140LIP8 (/ISO) A0A140LJ88 (/ISO) A0A140LJC1 (/ISO) Q6DR98 (/ISO)
Chemorepellent activity GO:0045499
Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a lower concentration of that signal.
9 A0A140LHG5 (/IDA) A0A140LHN1 (/IDA) A0A140LHZ9 (/IDA) A0A140LIJ3 (/IDA) A0A140LIK5 (/IDA) A0A140LIP8 (/IDA) A0A140LJ88 (/IDA) A0A140LJC1 (/IDA) Q6DR98 (/IDA)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
2 P43322 (/ISS) Q05199 (/ISS)
ErbB-3 class receptor binding GO:0043125
Interacting selectively and non-covalently with the protein-tyrosine kinase receptor ErbB-3/HER3.
2 P43322 (/ISS) Q05199 (/ISS)
Transcription cofactor activity GO:0003712
Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery.
1 Q02297 (/IDA)
Protein tyrosine kinase activity GO:0004713
Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
1 Q02297 (/TAS)
Ras guanyl-nucleotide exchange factor activity GO:0005088
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
1 Q02297 (/TAS)
Receptor binding GO:0005102
Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
1 Q02297 (/IPI)
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
1 Q02297 (/TAS)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
1 Q02297 (/IDA)
Growth factor activity GO:0008083
The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
1 Q02297 (/IDA)
Growth factor activity GO:0008083
The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation.
1 Q02297 (/NAS)
Protein tyrosine kinase activator activity GO:0030296
Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein.
1 Q02297 (/IDA)
Transmembrane receptor protein tyrosine kinase activator activity GO:0030297
Binds to and increases the activity of a transmembrane receptor protein tyrosine kinase.
1 Q02297 (/IC)
Transmembrane receptor protein tyrosine kinase activator activity GO:0030297
Binds to and increases the activity of a transmembrane receptor protein tyrosine kinase.
1 Q02297 (/NAS)
Receptor tyrosine kinase binding GO:0030971
Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.
1 P43322 (/IDA)
Receptor tyrosine kinase binding GO:0030971
Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.
1 Q02297 (/NAS)
ErbB-3 class receptor binding GO:0043125
Interacting selectively and non-covalently with the protein-tyrosine kinase receptor ErbB-3/HER3.
1 Q02297 (/IDA)
ErbB-3 class receptor binding GO:0043125
Interacting selectively and non-covalently with the protein-tyrosine kinase receptor ErbB-3/HER3.
1 Q02297 (/IPI)
Phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934
Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+).
1 Q02297 (/TAS)

There are 89 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
10 A0A140LHG5 (/IDA) A0A140LHN1 (/IDA) A0A140LHZ9 (/IDA) A0A140LIJ3 (/IDA) A0A140LIK5 (/IDA) A0A140LIP8 (/IDA) A0A140LJ88 (/IDA) A0A140LJC1 (/IDA) P43322 (/IDA) Q6DR98 (/IDA)
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
9 A0A140LHG5 (/IDA) A0A140LHN1 (/IDA) A0A140LHZ9 (/IDA) A0A140LIJ3 (/IDA) A0A140LIK5 (/IDA) A0A140LIP8 (/IDA) A0A140LJ88 (/IDA) A0A140LJC1 (/IDA) Q6DR98 (/IDA)
Cell morphogenesis GO:0000902
The developmental process in which the size or shape of a cell is generated and organized.
9 A0A140LHG5 (/IDA) A0A140LHN1 (/IDA) A0A140LHZ9 (/IDA) A0A140LIJ3 (/IDA) A0A140LIK5 (/IDA) A0A140LIP8 (/IDA) A0A140LJ88 (/IDA) A0A140LJC1 (/IDA) Q6DR98 (/IDA)
Startle response GO:0001964
An action or movement due to the application of a sudden unexpected stimulus.
9 A0A140LHG5 (/IMP) A0A140LHN1 (/IMP) A0A140LHZ9 (/IMP) A0A140LIJ3 (/IMP) A0A140LIK5 (/IMP) A0A140LIP8 (/IMP) A0A140LJ88 (/IMP) A0A140LJC1 (/IMP) Q6DR98 (/IMP)
Cardiac conduction system development GO:0003161
The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat.
9 A0A140LHG5 (/IDA) A0A140LHN1 (/IDA) A0A140LHZ9 (/IDA) A0A140LIJ3 (/IDA) A0A140LIK5 (/IDA) A0A140LIP8 (/IDA) A0A140LJ88 (/IDA) A0A140LJC1 (/IDA) Q6DR98 (/IDA)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
9 A0A140LHG5 (/IMP) A0A140LHN1 (/IMP) A0A140LHZ9 (/IMP) A0A140LIJ3 (/IMP) A0A140LIK5 (/IMP) A0A140LIP8 (/IMP) A0A140LJ88 (/IMP) A0A140LJC1 (/IMP) Q6DR98 (/IMP)
Synapse assembly GO:0007416
The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional).
9 A0A140LHG5 (/IMP) A0A140LHN1 (/IMP) A0A140LHZ9 (/IMP) A0A140LIJ3 (/IMP) A0A140LIK5 (/IMP) A0A140LIP8 (/IMP) A0A140LJ88 (/IMP) A0A140LJC1 (/IMP) Q6DR98 (/IMP)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
9 A0A140LHG5 (/IMP) A0A140LHN1 (/IMP) A0A140LHZ9 (/IMP) A0A140LIJ3 (/IMP) A0A140LIK5 (/IMP) A0A140LIP8 (/IMP) A0A140LJ88 (/IMP) A0A140LJC1 (/IMP) Q6DR98 (/IMP)
Peripheral nervous system development GO:0007422
The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands.
9 A0A140LHG5 (/IMP) A0A140LHN1 (/IMP) A0A140LHZ9 (/IMP) A0A140LIJ3 (/IMP) A0A140LIK5 (/IMP) A0A140LIP8 (/IMP) A0A140LJ88 (/IMP) A0A140LJC1 (/IMP) Q6DR98 (/IMP)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
9 A0A140LHG5 (/IMP) A0A140LHN1 (/IMP) A0A140LHZ9 (/IMP) A0A140LIJ3 (/IMP) A0A140LIK5 (/IMP) A0A140LIP8 (/IMP) A0A140LJ88 (/IMP) A0A140LJC1 (/IMP) Q6DR98 (/IMP)
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
9 A0A140LHG5 (/IMP) A0A140LHN1 (/IMP) A0A140LHZ9 (/IMP) A0A140LIJ3 (/IMP) A0A140LIK5 (/IMP) A0A140LIP8 (/IMP) A0A140LJ88 (/IMP) A0A140LJC1 (/IMP) Q6DR98 (/IMP)
Locomotory behavior GO:0007626
The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.
9 A0A140LHG5 (/IMP) A0A140LHN1 (/IMP) A0A140LHZ9 (/IMP) A0A140LIJ3 (/IMP) A0A140LIK5 (/IMP) A0A140LIP8 (/IMP) A0A140LJ88 (/IMP) A0A140LJC1 (/IMP) Q6DR98 (/IMP)
Axon ensheathment GO:0008366
Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal.
9 A0A140LHG5 (/IMP) A0A140LHN1 (/IMP) A0A140LHZ9 (/IMP) A0A140LIJ3 (/IMP) A0A140LIK5 (/IMP) A0A140LIP8 (/IMP) A0A140LJ88 (/IMP) A0A140LJC1 (/IMP) Q6DR98 (/IMP)
Glial cell differentiation GO:0010001
The process in which a relatively unspecialized cell acquires the specialized features of a glial cell.
9 A0A140LHG5 (/IMP) A0A140LHN1 (/IMP) A0A140LHZ9 (/IMP) A0A140LIJ3 (/IMP) A0A140LIK5 (/IMP) A0A140LIP8 (/IMP) A0A140LJ88 (/IMP) A0A140LJC1 (/IMP) Q6DR98 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
9 A0A140LHG5 (/IDA) A0A140LHN1 (/IDA) A0A140LHZ9 (/IDA) A0A140LIJ3 (/IDA) A0A140LIK5 (/IDA) A0A140LIP8 (/IDA) A0A140LJ88 (/IDA) A0A140LJC1 (/IDA) Q6DR98 (/IDA)
Positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
9 A0A140LHG5 (/IGI) A0A140LHN1 (/IGI) A0A140LHZ9 (/IGI) A0A140LIJ3 (/IGI) A0A140LIK5 (/IGI) A0A140LIP8 (/IGI) A0A140LJ88 (/IGI) A0A140LJC1 (/IGI) Q6DR98 (/IGI)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
9 A0A140LHG5 (/IGI) A0A140LHN1 (/IGI) A0A140LHZ9 (/IGI) A0A140LIJ3 (/IGI) A0A140LIK5 (/IGI) A0A140LIP8 (/IGI) A0A140LJ88 (/IGI) A0A140LJC1 (/IGI) Q6DR98 (/IGI)
Glial cell fate commitment GO:0021781
The process in which the developmental fate of a cell becomes restricted such that it will develop into a glial cell.
9 A0A140LHG5 (/IDA) A0A140LHN1 (/IDA) A0A140LHZ9 (/IDA) A0A140LIJ3 (/IDA) A0A140LIK5 (/IDA) A0A140LIP8 (/IDA) A0A140LJ88 (/IDA) A0A140LJC1 (/IDA) Q6DR98 (/IDA)
Chemorepulsion involved in interneuron migration from the subpallium to the cortex GO:0021842
The creation and reception of signals that result in the movement of interneurons away from the signal during migration from the subpallium to the cortex.
9 A0A140LHG5 (/IMP) A0A140LHN1 (/IMP) A0A140LHZ9 (/IMP) A0A140LIJ3 (/IMP) A0A140LIK5 (/IMP) A0A140LIP8 (/IMP) A0A140LJ88 (/IMP) A0A140LJC1 (/IMP) Q6DR98 (/IMP)
Neurogenesis GO:0022008
Generation of cells within the nervous system.
9 A0A140LHG5 (/IGI) A0A140LHN1 (/IGI) A0A140LHZ9 (/IGI) A0A140LIJ3 (/IGI) A0A140LIK5 (/IGI) A0A140LIP8 (/IGI) A0A140LJ88 (/IGI) A0A140LJC1 (/IGI) Q6DR98 (/IGI)
Neurogenesis GO:0022008
Generation of cells within the nervous system.
9 A0A140LHG5 (/IMP) A0A140LHN1 (/IMP) A0A140LHZ9 (/IMP) A0A140LIJ3 (/IMP) A0A140LIK5 (/IMP) A0A140LIP8 (/IMP) A0A140LJ88 (/IMP) A0A140LJC1 (/IMP) Q6DR98 (/IMP)
Positive regulation of myelination GO:0031643
Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons.
9 A0A140LHG5 (/IMP) A0A140LHN1 (/IMP) A0A140LHZ9 (/IMP) A0A140LIJ3 (/IMP) A0A140LIK5 (/IMP) A0A140LIP8 (/IMP) A0A140LJ88 (/IMP) A0A140LJC1 (/IMP) Q6DR98 (/IMP)
Negative regulation of protein catabolic process GO:0042177
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
9 A0A140LHG5 (/IDA) A0A140LHN1 (/IDA) A0A140LHZ9 (/IDA) A0A140LIJ3 (/IDA) A0A140LIK5 (/IDA) A0A140LIP8 (/IDA) A0A140LJ88 (/IDA) A0A140LJC1 (/IDA) Q6DR98 (/IDA)
Cellular protein complex disassembly GO:0043624
The disaggregation of a protein complex into its constituent components, occurring at the level of an individual cell. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups.
9 A0A140LHG5 (/ISO) A0A140LHN1 (/ISO) A0A140LHZ9 (/ISO) A0A140LIJ3 (/ISO) A0A140LIK5 (/ISO) A0A140LIP8 (/ISO) A0A140LJ88 (/ISO) A0A140LJC1 (/ISO) Q6DR98 (/ISO)
Neurotransmitter receptor metabolic process GO:0045213
The chemical reactions and pathways involving neurotransmitter receptors.
9 A0A140LHG5 (/IMP) A0A140LHN1 (/IMP) A0A140LHZ9 (/IMP) A0A140LIJ3 (/IMP) A0A140LIK5 (/IMP) A0A140LIP8 (/IMP) A0A140LJ88 (/IMP) A0A140LJC1 (/IMP) Q6DR98 (/IMP)
Regulation of cell differentiation GO:0045595
Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features.
9 A0A140LHG5 (/IMP) A0A140LHN1 (/IMP) A0A140LHZ9 (/IMP) A0A140LIJ3 (/IMP) A0A140LIK5 (/IMP) A0A140LIP8 (/IMP) A0A140LJ88 (/IMP) A0A140LJC1 (/IMP) Q6DR98 (/IMP)
Positive regulation of axon extension GO:0045773
Any process that activates or increases the frequency, rate or extent of axon extension.
9 A0A140LHG5 (/IMP) A0A140LHN1 (/IMP) A0A140LHZ9 (/IMP) A0A140LIJ3 (/IMP) A0A140LIK5 (/IMP) A0A140LIP8 (/IMP) A0A140LJ88 (/IMP) A0A140LJC1 (/IMP) Q6DR98 (/IMP)
Positive regulation of protein kinase activity GO:0045860
Any process that activates or increases the frequency, rate or extent of protein kinase activity.
9 A0A140LHG5 (/IDA) A0A140LHN1 (/IDA) A0A140LHZ9 (/IDA) A0A140LIJ3 (/IDA) A0A140LIK5 (/IDA) A0A140LIP8 (/IDA) A0A140LJ88 (/IDA) A0A140LJC1 (/IDA) Q6DR98 (/IDA)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
9 A0A140LHG5 (/ISO) A0A140LHN1 (/ISO) A0A140LHZ9 (/ISO) A0A140LIJ3 (/ISO) A0A140LIK5 (/ISO) A0A140LIP8 (/ISO) A0A140LJ88 (/ISO) A0A140LJC1 (/ISO) Q6DR98 (/ISO)
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
9 A0A140LHG5 (/IMP) A0A140LHN1 (/IMP) A0A140LHZ9 (/IMP) A0A140LIJ3 (/IMP) A0A140LIK5 (/IMP) A0A140LIP8 (/IMP) A0A140LJ88 (/IMP) A0A140LJC1 (/IMP) Q6DR98 (/IMP)
Positive regulation of Ras protein signal transduction GO:0046579
Any process that activates or increases the frequency, rate or extent of Ras protein signal transduction.
9 A0A140LHG5 (/IDA) A0A140LHN1 (/IDA) A0A140LHZ9 (/IDA) A0A140LIJ3 (/IDA) A0A140LIK5 (/IDA) A0A140LIP8 (/IDA) A0A140LJ88 (/IDA) A0A140LJC1 (/IDA) Q6DR98 (/IDA)
Neuron fate commitment GO:0048663
The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron.
9 A0A140LHG5 (/IMP) A0A140LHN1 (/IMP) A0A140LHZ9 (/IMP) A0A140LIJ3 (/IMP) A0A140LIK5 (/IMP) A0A140LIP8 (/IMP) A0A140LJ88 (/IMP) A0A140LJC1 (/IMP) Q6DR98 (/IMP)
Oligodendrocyte differentiation GO:0048709
The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system.
9 A0A140LHG5 (/IMP) A0A140LHN1 (/IMP) A0A140LHZ9 (/IMP) A0A140LIJ3 (/IMP) A0A140LIK5 (/IMP) A0A140LIP8 (/IMP) A0A140LJ88 (/IMP) A0A140LJC1 (/IMP) Q6DR98 (/IMP)
Cardiac muscle tissue development GO:0048738
The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure.
9 A0A140LHG5 (/IDA) A0A140LHN1 (/IDA) A0A140LHZ9 (/IDA) A0A140LIJ3 (/IDA) A0A140LIK5 (/IDA) A0A140LIP8 (/IDA) A0A140LJ88 (/IDA) A0A140LJC1 (/IDA) Q6DR98 (/IDA)
Positive regulation of protein kinase B signaling GO:0051897
Any process that activates or increases the frequency, rate or extent of protein kinase B signaling, a series of reactions mediated by the intracellular serine/threonine kinase protein kinase B.
9 A0A140LHG5 (/IDA) A0A140LHN1 (/IDA) A0A140LHZ9 (/IDA) A0A140LIJ3 (/IDA) A0A140LIK5 (/IDA) A0A140LIP8 (/IDA) A0A140LJ88 (/IDA) A0A140LJC1 (/IDA) Q6DR98 (/IDA)
Positive regulation of dendritic spine development GO:0060999
Any process that increases the rate, frequency, or extent of dendritic spine development, the process whose specific outcome is the progression of the dendritic spine over time, from its formation to the mature structure.
9 A0A140LHG5 (/IMP) A0A140LHN1 (/IMP) A0A140LHZ9 (/IMP) A0A140LIJ3 (/IMP) A0A140LIK5 (/IMP) A0A140LIP8 (/IMP) A0A140LJ88 (/IMP) A0A140LJC1 (/IMP) Q6DR98 (/IMP)
Positive regulation of calcineurin-NFAT signaling cascade GO:0070886
Any process that activates or increases the frequency, rate or extent of signaling via the calcineurin-NFAT signaling cascade.
9 A0A140LHG5 (/IGI) A0A140LHN1 (/IGI) A0A140LHZ9 (/IGI) A0A140LIJ3 (/IGI) A0A140LIK5 (/IGI) A0A140LIP8 (/IGI) A0A140LJ88 (/IGI) A0A140LJC1 (/IGI) Q6DR98 (/IGI)
Positive regulation of protein localization to cell surface GO:2000010
Any process that activates or increases the frequency, rate or extent of protein localization to the cell surface.
9 A0A140LHG5 (/IGI) A0A140LHN1 (/IGI) A0A140LHZ9 (/IGI) A0A140LIJ3 (/IGI) A0A140LIK5 (/IGI) A0A140LIP8 (/IGI) A0A140LJ88 (/IGI) A0A140LJC1 (/IGI) Q6DR98 (/IGI)
Negative regulation of neuron migration GO:2001223
Any process that stops, prevents or reduces the frequency, rate or extent of neuron migration.
9 A0A140LHG5 (/IDA) A0A140LHN1 (/IDA) A0A140LHZ9 (/IDA) A0A140LIJ3 (/IDA) A0A140LIK5 (/IDA) A0A140LIP8 (/IDA) A0A140LJ88 (/IDA) A0A140LJC1 (/IDA) Q6DR98 (/IDA)
ERBB signaling pathway GO:0038127
A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptor tyrosine kinases on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P43322 (/ISS) Q05199 (/ISS)
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
1 Q02297 (/TAS)
Activation of MAPK activity GO:0000187
The initiation of the activity of the inactive enzyme MAP kinase (MAPK).
1 Q02297 (/IMP)
Activation of MAPK activity GO:0000187
The initiation of the activity of the inactive enzyme MAP kinase (MAPK).
1 P43322 (/ISS)
Ventricular trabecula myocardium morphogenesis GO:0003222
The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized.
1 Q02297 (/IDA)
Cell communication GO:0007154
Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
1 Q02297 (/TAS)
Transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q02297 (/IDA)
Activation of transmembrane receptor protein tyrosine kinase activity GO:0007171
Any process that initiates the activity of the inactive transmembrane receptor protein tyrosine kinase activity.
1 Q02297 (/IDA)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
1 Q02297 (/TAS)
Memory GO:0007613
The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).
1 P43322 (/IMP)
Cell proliferation GO:0008283
The multiplication or reproduction of cells, resulting in the expansion of a cell population.
1 Q02297 (/IDA)
Positive regulation of cell proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 P43322 (/IDA)
Positive regulation of cell proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 Q02297 (/IMP)
Positive regulation of Schwann cell proliferation GO:0010625
Any process that increases the frequency or rate of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system.
1 P43322 (/IMP)
Negative regulation of cardiac muscle cell apoptotic process GO:0010667
Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.
1 Q02297 (/IDA)
Positive regulation of neuron projection development GO:0010976
Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
1 P43322 (/IDA)
Neural crest cell development GO:0014032
The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.
1 Q02297 (/TAS)
Regulation of phosphatidylinositol 3-kinase signaling GO:0014066
Any process that modulates the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.
1 Q02297 (/TAS)
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
1 Q02297 (/IDA)
Mammary gland development GO:0030879
The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages.
1 Q02297 (/TAS)
Activation of protein kinase B activity GO:0032148
Any process that initiates the activity of the inactive enzyme protein kinase B.
1 Q02297 (/IMP)
Activation of protein kinase B activity GO:0032148
Any process that initiates the activity of the inactive enzyme protein kinase B.
1 P43322 (/ISS)
Response to progesterone GO:0032570
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus.
1 P43322 (/IEP)
ERBB signaling pathway GO:0038127
A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptor tyrosine kinases on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q02297 (/IDA)
ERBB signaling pathway GO:0038127
A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptor tyrosine kinases on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q02297 (/IMP)
ERBB2 signaling pathway GO:0038128
A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptors on the surface of a cell, where the signal is transmitted by ERBB2. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair.
1 Q02297 (/TAS)
ERBB3 signaling pathway GO:0038129
A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB3 on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB3 receptors have impaired kinase activity and rely on the kinase activity of the heterodimer partner for activation and signal transmission.
1 Q02297 (/IDA)
Wound healing GO:0042060
The series of events that restore integrity to a damaged tissue, following an injury.
1 Q02297 (/IDA)
Wound healing GO:0042060
The series of events that restore integrity to a damaged tissue, following an injury.
1 Q02297 (/TAS)
Regulation of protein homodimerization activity GO:0043496
Any process that modulates the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer.
1 Q02297 (/TAS)
Regulation of protein heterodimerization activity GO:0043497
Any process that modulates the frequency, rate or extent of protein heterodimerization, interacting selectively with a nonidentical protein to form a heterodimer.
1 Q02297 (/IDA)
Cellular protein complex disassembly GO:0043624
The disaggregation of a protein complex into its constituent components, occurring at the level of an individual cell. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups.
1 Q02297 (/IGI)
Positive regulation of cell adhesion GO:0045785
Any process that activates or increases the frequency, rate or extent of cell adhesion.
1 Q02297 (/IDA)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 Q02297 (/IDA)
Phosphatidylinositol-mediated signaling GO:0048015
A series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.
1 Q02297 (/TAS)
Positive regulation of axon regeneration GO:0048680
Any process that activates, maintains or increases the rate of axon regeneration.
1 P43322 (/IDA)
Negative regulation of secretion GO:0051048
Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.
1 Q02297 (/IDA)
Positive regulation of striated muscle cell differentiation GO:0051155
Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation.
1 Q6DR98 (/IMP)
Positive regulation of striated muscle cell differentiation GO:0051155
Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation.
1 Q02297 (/ISS)
Cardiac muscle cell differentiation GO:0055007
The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.
1 Q6DR98 (/IMP)
Cardiac muscle cell differentiation GO:0055007
The process in which a cardiac muscle precursor cell acquires specialized features of a cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction.
1 Q02297 (/ISS)
Ventricular cardiac muscle cell differentiation GO:0055012
The process in which a relatively unspecialized cell acquires specialized features of a ventricular cardiac muscle cell. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. The ventricle is the part of the heart that pumps blood out of the organ.
1 Q02297 (/IDA)
Positive regulation of cardiac muscle cell proliferation GO:0060045
Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation.
1 Q02297 (/IDA)
Cardiac muscle cell myoblast differentiation GO:0060379
The process in which a relatively unspecialized cell acquires specialized features of a cardiac myoblast. A cardiac myoblast is a precursor cell that has been committed to a cardiac muscle cell fate but retains the ability to divide and proliferate throughout life.
1 Q02297 (/IDA)
Endocardial cell differentiation GO:0060956
The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an endocardial cell. An endocardial cell is a specialized endothelial cell that makes up the endocardium portion of the heart. The endocardium is the innermost layer of tissue of the heart, and lines the heart chambers.
1 Q02297 (/IDA)
Negative regulation of ERBB signaling pathway GO:1901185
Any process that stops, prevents or reduces the frequency, rate or extent of ERBB signaling pathway.
1 Q02297 (/TAS)
Positive regulation of protein targeting to mitochondrion GO:1903955
Any process that activates or increases the frequency, rate or extent of protein targeting to mitochondrion.
1 Q02297 (/IMP)
Regulation of cell motility GO:2000145
Any process that modulates the frequency, rate or extent of cell motility.
1 Q02297 (/TAS)
Negative regulation of corticosterone secretion GO:2000853
Any process that stops, prevents or reduces the frequency, rate or extent of corticosterone secretion.
1 P43322 (/IMP)
Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240
Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand.
1 Q02297 (/IDA)

There are 18 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
10 A0A140LHG5 (/IDA) A0A140LHN1 (/IDA) A0A140LHZ9 (/IDA) A0A140LIJ3 (/IDA) A0A140LIK5 (/IDA) A0A140LIP8 (/IDA) A0A140LJ88 (/IDA) A0A140LJC1 (/IDA) P43322 (/IDA) Q6DR98 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
9 A0A140LHG5 (/IDA) A0A140LHN1 (/IDA) A0A140LHZ9 (/IDA) A0A140LIJ3 (/IDA) A0A140LIK5 (/IDA) A0A140LIP8 (/IDA) A0A140LJ88 (/IDA) A0A140LJC1 (/IDA) Q6DR98 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
9 A0A140LHG5 (/IDA) A0A140LHN1 (/IDA) A0A140LHZ9 (/IDA) A0A140LIJ3 (/IDA) A0A140LIK5 (/IDA) A0A140LIP8 (/IDA) A0A140LJ88 (/IDA) A0A140LJC1 (/IDA) Q6DR98 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
9 A0A140LHG5 (/IDA) A0A140LHN1 (/IDA) A0A140LHZ9 (/IDA) A0A140LIJ3 (/IDA) A0A140LIK5 (/IDA) A0A140LIP8 (/IDA) A0A140LJ88 (/IDA) A0A140LJC1 (/IDA) Q6DR98 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
9 A0A140LHG5 (/IDA) A0A140LHN1 (/IDA) A0A140LHZ9 (/IDA) A0A140LIJ3 (/IDA) A0A140LIK5 (/IDA) A0A140LIP8 (/IDA) A0A140LJ88 (/IDA) A0A140LJC1 (/IDA) Q6DR98 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
9 A0A140LHG5 (/IDA) A0A140LHN1 (/IDA) A0A140LHZ9 (/IDA) A0A140LIJ3 (/IDA) A0A140LIK5 (/IDA) A0A140LIP8 (/IDA) A0A140LJ88 (/IDA) A0A140LJC1 (/IDA) Q6DR98 (/IDA)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
9 A0A140LHG5 (/IDA) A0A140LHN1 (/IDA) A0A140LHZ9 (/IDA) A0A140LIJ3 (/IDA) A0A140LIK5 (/IDA) A0A140LIP8 (/IDA) A0A140LJ88 (/IDA) A0A140LJC1 (/IDA) Q6DR98 (/IDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
9 A0A140LHG5 (/IDA) A0A140LHN1 (/IDA) A0A140LHZ9 (/IDA) A0A140LIJ3 (/IDA) A0A140LIK5 (/IDA) A0A140LIP8 (/IDA) A0A140LJ88 (/IDA) A0A140LJC1 (/IDA) Q6DR98 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
9 A0A140LHG5 (/IDA) A0A140LHN1 (/IDA) A0A140LHZ9 (/IDA) A0A140LIJ3 (/IDA) A0A140LIK5 (/IDA) A0A140LIP8 (/IDA) A0A140LJ88 (/IDA) A0A140LJC1 (/IDA) Q6DR98 (/IDA)
Axolemma GO:0030673
The portion of the plasma membrane surrounding an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness.
9 A0A140LHG5 (/IDA) A0A140LHN1 (/IDA) A0A140LHZ9 (/IDA) A0A140LIJ3 (/IDA) A0A140LIK5 (/IDA) A0A140LIP8 (/IDA) A0A140LJ88 (/IDA) A0A140LJC1 (/IDA) Q6DR98 (/IDA)
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
9 A0A140LHG5 (/IDA) A0A140LHN1 (/IDA) A0A140LHZ9 (/IDA) A0A140LIJ3 (/IDA) A0A140LIK5 (/IDA) A0A140LIP8 (/IDA) A0A140LJ88 (/IDA) A0A140LJC1 (/IDA) Q6DR98 (/IDA)
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
9 A0A140LHG5 (/IDA) A0A140LHN1 (/IDA) A0A140LHZ9 (/IDA) A0A140LIJ3 (/IDA) A0A140LIK5 (/IDA) A0A140LIP8 (/IDA) A0A140LJ88 (/IDA) A0A140LJC1 (/IDA) Q6DR98 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P43322 (/IDA) Q02297 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 E7EX30 (/IDA) Q02297 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 Q02297 (/NAS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 Q02297 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q02297 (/NAS)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 Q02297 (/IDA)
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