The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Immunoglobulins
".
FunFam 133288: Leukocyte immunoglobulin-like receptor a
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 21 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Antigen binding GO:0003823
Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen.
|
3 | O75019 (/TAS) Q8N149 (/TAS) Q8N6C8 (/TAS) |
Receptor activity GO:0004872
Combining with an extracellular or intracellular messenger to initiate a change in cell activity.
|
3 | Q8N149 (/TAS) Q8N423 (/TAS) Q8N6C8 (/TAS) |
Protein phosphatase 1 binding GO:0008157
Interacting selectively and non-covalently with the enzyme protein phosphatase 1.
|
2 | Q8N423 (/IPI) Q8NHL6 (/IPI) |
HLA-A specific inhibitory MHC class I receptor activity GO:0030107
Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
HLA-B specific inhibitory MHC class I receptor activity GO:0030109
Combining with a MHC class I molecule of the HLA-B subclass to mediate signaling that inhibits activation of a lymphocyte.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
MHC class I receptor activity GO:0032393
Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
MHC class I protein binding GO:0042288
Interacting selectively and non-covalently with major histocompatibility complex class I molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.
|
2 | Q8N423 (/IDA) Q8NHL6 (/IDA) |
MHC class I protein binding GO:0042288
Interacting selectively and non-covalently with major histocompatibility complex class I molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.
|
2 | Q8N423 (/IPI) Q8NHL6 (/IPI) |
MHC class I protein binding GO:0042288
Interacting selectively and non-covalently with major histocompatibility complex class I molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
Transmembrane signaling receptor activity GO:0004888
Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
|
1 | O75019 (/TAS) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | Q8N423 (/IPI) |
MHC class Ib protein binding GO:0023029
Interacting selectively and non-covalently with major histocompatibility complex class Ib molecules.
|
1 | Q8N423 (/IPI) |
HLA-A specific inhibitory MHC class I receptor activity GO:0030107
Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte.
|
1 | Q8NHL6 (/IDA) |
HLA-B specific inhibitory MHC class I receptor activity GO:0030109
Combining with a MHC class I molecule of the HLA-B subclass to mediate signaling that inhibits activation of a lymphocyte.
|
1 | Q8NHL6 (/IDA) |
MHC class I receptor activity GO:0032393
Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules.
|
1 | Q8NHL6 (/IDA) |
Inhibitory MHC class I receptor activity GO:0032396
Combining with a MHC class I protein complex to mediate signaling that inhibits activation of a lymphocyte.
|
1 | Q8N423 (/IDA) |
Inhibitory MHC class I receptor activity GO:0032396
Combining with a MHC class I protein complex to mediate signaling that inhibits activation of a lymphocyte.
|
1 | Q8N423 (/IMP) |
SH2 domain binding GO:0042169
Interacting selectively and non-covalently with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class.
|
1 | Q8NHL6 (/IDA) |
MHC class I protein binding GO:0042288
Interacting selectively and non-covalently with major histocompatibility complex class I molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation.
|
1 | Q8NHL6 (/IMP) |
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
1 | Q8NHL6 (/IPI) |
Cell adhesion molecule binding GO:0050839
Interacting selectively and non-covalently with a cell adhesion molecule.
|
1 | Q8N423 (/IPI) |
There are 95 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Defense response GO:0006952
Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
|
3 | O75019 (/TAS) Q8N149 (/TAS) Q8N6C8 (/TAS) |
Regulation of immune response GO:0050776
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
|
3 | O75019 (/TAS) Q8N423 (/TAS) Q8NHL6 (/TAS) |
Negative regulation of T cell mediated cytotoxicity GO:0001915
Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
Positive regulation of defense response to virus by host GO:0002230
Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
T cell proliferation involved in immune response GO:0002309
The expansion of a T cell population by cell division as part of an immune response.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
Negative regulation of cytokine secretion involved in immune response GO:0002740
Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine secretion contributing to an immune response.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
Fc receptor mediated inhibitory signaling pathway GO:0002774
A series of molecular signals generated as a consequence of the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of inhibiting an immune effector process contributing to an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region.
|
2 | Q8N423 (/IDA) Q8NHL6 (/IDA) |
Fc receptor mediated inhibitory signaling pathway GO:0002774
A series of molecular signals generated as a consequence of the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of inhibiting an immune effector process contributing to an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
|
2 | Q8N423 (/IDA) Q8NHL6 (/IDA) |
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
|
2 | Q8N149 (/TAS) Q8N6C8 (/TAS) |
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
|
2 | O75019 (/TAS) Q8N423 (/TAS) |
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
Negative regulation of serotonin secretion GO:0014063
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
Negative regulation of interferon-gamma production GO:0032689
Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
Negative regulation of mononuclear cell proliferation GO:0032945
Any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
Negative regulation of interferon-beta secretion GO:0035548
Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta secretion.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
Negative regulation of T cell proliferation GO:0042130
Any process that stops, prevents or reduces the rate or extent of T cell proliferation.
|
2 | Q8N423 (/IDA) Q8NHL6 (/IDA) |
Negative regulation of T cell proliferation GO:0042130
Any process that stops, prevents or reduces the rate or extent of T cell proliferation.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
Negative regulation of tumor necrosis factor biosynthetic process GO:0042536
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
|
2 | Q8N423 (/TAS) Q8N6C8 (/TAS) |
Negative regulation of interferon-gamma biosynthetic process GO:0045077
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
Negative regulation of cell cycle GO:0045786
Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
Negative regulation of endocytosis GO:0045806
Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
Positive regulation of cytolysis GO:0045919
Any process that activates or increases the frequency, rate or extent of cytolysis.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
Negative regulation of natural killer cell mediated cytotoxicity GO:0045953
Any process that stops, prevents, or reduces the rate of natural killer mediated cytotoxicity.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
Negative regulation of alpha-beta T cell activation GO:0046636
Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell activation.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
Negative regulation of calcium ion transport GO:0051926
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | Q8N423 (/IDA) Q8NHL6 (/IDA) |
Negative regulation of calcium ion transport GO:0051926
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
Interferon-gamma secretion GO:0072643
The regulated release of interferon-gamma from a cell.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
Negative regulation of dendritic cell apoptotic process GO:2000669
Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell apoptotic process.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
Negative regulation of interleukin-10 secretion GO:2001180
Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-10 secretion.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
Negative regulation of interleukin-12 secretion GO:2001183
Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-12 secretion.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
Negative regulation of CD8-positive, alpha-beta T cell activation GO:2001186
Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell activation.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
Negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:2001189
Any process that stops, prevents or reduces the frequency, rate or extent of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
Positive regulation of gamma-delta T cell activation involved in immune response GO:2001193
Any process that activates or increases the frequency, rate or extent of gamma-delta T cell activation involved in immune response.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
Negative regulation of dendritic cell differentiation GO:2001199
Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell differentiation.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
Negative regulation of transforming growth factor-beta secretion GO:2001202
Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor-beta secretion.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
Negative regulation of osteoclast development GO:2001205
Any process that stops, prevents or reduces the frequency, rate or extent of osteoclast development.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
Negative regulation of T cell mediated cytotoxicity GO:0001915
Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity.
|
1 | Q8NHL6 (/IDA) |
Positive regulation of defense response to virus by host GO:0002230
Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication.
|
1 | Q8NHL6 (/IDA) |
T cell proliferation involved in immune response GO:0002309
The expansion of a T cell population by cell division as part of an immune response.
|
1 | Q8NHL6 (/IDA) |
Negative regulation of antigen processing and presentation GO:0002578
Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation.
|
1 | Q8N423 (/IDA) |
Positive regulation of tolerance induction GO:0002645
Any process that activates or increases the frequency, rate, or extent of tolerance induction.
|
1 | Q8N423 (/IMP) |
Positive regulation of T cell tolerance induction GO:0002666
Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction.
|
1 | Q8N423 (/IMP) |
Negative regulation of cytokine secretion involved in immune response GO:0002740
Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine secretion contributing to an immune response.
|
1 | Q8NHL6 (/IDA) |
Immune response-inhibiting cell surface receptor signaling pathway GO:0002767
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of inhibiting an immune response.
|
1 | Q8N423 (/IDA) |
Immune response-inhibiting cell surface receptor signaling pathway GO:0002767
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of inhibiting an immune response.
|
1 | Q8N423 (/IMP) |
Immune response-inhibiting cell surface receptor signaling pathway GO:0002767
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of inhibiting an immune response.
|
1 | Q8NHL6 (/NAS) |
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
|
1 | Q8N423 (/TAS) |
Cellular defense response GO:0006968
A defense response that is mediated by cells.
|
1 | Q8N423 (/TAS) |
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
|
1 | Q8N423 (/IMP) |
Cell-cell signaling GO:0007267
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
|
1 | Q8N423 (/TAS) |
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
|
1 | Q8NHL6 (/IDA) |
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
|
1 | Q8NHL6 (/IDA) |
Negative regulation of serotonin secretion GO:0014063
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin.
|
1 | Q8NHL6 (/IDA) |
Receptor internalization GO:0031623
A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.
|
1 | Q8NHL6 (/TAS) |
Interferon-gamma production GO:0032609
The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon.
|
1 | Q8NHL6 (/IDA) |
Negative regulation of interferon-gamma production GO:0032689
Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
|
1 | Q8NHL6 (/IDA) |
Positive regulation of interleukin-6 production GO:0032755
Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.
|
1 | Q8N423 (/NAS) |
Negative regulation of mononuclear cell proliferation GO:0032945
Any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation.
|
1 | Q8NHL6 (/IDA) |
Heterotypic cell-cell adhesion GO:0034113
The attachment of a cell to a cell of a different type via adhesion molecules.
|
1 | Q8N423 (/IDA) |
Negative regulation of interferon-beta secretion GO:0035548
Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta secretion.
|
1 | Q8NHL6 (/IDA) |
Positive regulation of T cell proliferation GO:0042102
Any process that activates or increases the rate or extent of T cell proliferation.
|
1 | Q8N423 (/IDA) |
Negative regulation of T cell proliferation GO:0042130
Any process that stops, prevents or reduces the rate or extent of T cell proliferation.
|
1 | Q8N423 (/IMP) |
Negative regulation of tumor necrosis factor biosynthetic process GO:0042536
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.
|
1 | Q8NHL6 (/IDA) |
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
1 | Q8NHL6 (/IDA) |
Negative regulation of interferon-gamma biosynthetic process GO:0045077
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma.
|
1 | Q8NHL6 (/IDA) |
Positive regulation of regulatory T cell differentiation GO:0045591
Any process that activates or increases the frequency, rate or extent of differentiation of regulatory T cells.
|
1 | Q8N423 (/IMP) |
Negative regulation of cell cycle GO:0045786
Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.
|
1 | Q8NHL6 (/IDA) |
Negative regulation of endocytosis GO:0045806
Any process that stops, prevents, or reduces the frequency, rate or extent of endocytosis.
|
1 | Q8NHL6 (/IDA) |
Positive regulation of cytolysis GO:0045919
Any process that activates or increases the frequency, rate or extent of cytolysis.
|
1 | Q8NHL6 (/IDA) |
Positive regulation of cytolysis GO:0045919
Any process that activates or increases the frequency, rate or extent of cytolysis.
|
1 | Q8NHL6 (/IMP) |
Positive regulation of transcription from RNA polymerase II promoter GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
|
1 | Q8NHL6 (/NAS) |
Negative regulation of natural killer cell mediated cytotoxicity GO:0045953
Any process that stops, prevents, or reduces the rate of natural killer mediated cytotoxicity.
|
1 | Q8NHL6 (/IDA) |
Negative regulation of alpha-beta T cell activation GO:0046636
Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell activation.
|
1 | Q8NHL6 (/IDA) |
Negative regulation of immune response GO:0050777
Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
|
1 | Q8N423 (/IC) |
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
|
1 | Q8NHL6 (/IDA) |
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
|
1 | Q8NHL6 (/IEP) |
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
|
1 | Q8N423 (/IMP) |
Interferon-gamma secretion GO:0072643
The regulated release of interferon-gamma from a cell.
|
1 | Q8NHL6 (/IDA) |
Dendritic cell differentiation GO:0097028
The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.
|
1 | Q8NHL6 (/IEP) |
Negative regulation of dendritic cell apoptotic process GO:2000669
Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell apoptotic process.
|
1 | Q8NHL6 (/IDA) |
Negative regulation of interleukin-10 secretion GO:2001180
Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-10 secretion.
|
1 | Q8NHL6 (/IDA) |
Negative regulation of interleukin-12 secretion GO:2001183
Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-12 secretion.
|
1 | Q8NHL6 (/IDA) |
Negative regulation of CD8-positive, alpha-beta T cell activation GO:2001186
Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell activation.
|
1 | Q8NHL6 (/IDA) |
Negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:2001189
Any process that stops, prevents or reduces the frequency, rate or extent of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell.
|
1 | Q8NHL6 (/IDA) |
Positive regulation of gamma-delta T cell activation involved in immune response GO:2001193
Any process that activates or increases the frequency, rate or extent of gamma-delta T cell activation involved in immune response.
|
1 | Q8NHL6 (/IDA) |
Regulation of dendritic cell differentiation GO:2001198
Any process that modulates the frequency, rate or extent of dendritic cell differentiation.
|
1 | Q8N423 (/IC) |
Negative regulation of dendritic cell differentiation GO:2001199
Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell differentiation.
|
1 | Q8NHL6 (/IMP) |
Negative regulation of transforming growth factor-beta secretion GO:2001202
Any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor-beta secretion.
|
1 | Q8NHL6 (/IDA) |
Negative regulation of osteoclast development GO:2001205
Any process that stops, prevents or reduces the frequency, rate or extent of osteoclast development.
|
1 | Q8NHL6 (/IDA) |
There are 13 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
4 | O75019 (/TAS) Q8N423 (/TAS) Q8N6C8 (/TAS) Q8NHL6 (/TAS) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q8N423 (/IDA) Q8NHL6 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
2 | A9L916 (/ISS) G3QW36 (/ISS) |
Tertiary granule membrane GO:0070821
The lipid bilayer surrounding a tertiary granule.
|
2 | Q8N423 (/TAS) Q8N6C8 (/TAS) |
Ficolin-1-rich granule membrane GO:0101003
The lipid bilayer surrounding a ficolin-1-rich granule.
|
2 | Q8N423 (/TAS) Q8N6C8 (/TAS) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | Q8N423 (/IDA) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | Q8N423 (/IC) |
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | Q8N423 (/TAS) |
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
1 | Q8NHL6 (/IDA) |
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
1 | Q8N423 (/IDA) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q8N423 (/TAS) |
Specific granule membrane GO:0035579
The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
|
1 | Q8N6C8 (/TAS) |