The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Immunoglobulins
".
FunFam 132734: Neural cell adhesion molecule 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 8 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
6 | P13590 (/IPI) P13590 (/IPI) P13595 (/IPI) P13595 (/IPI) P13596 (/IPI) P13596 (/IPI) |
Fibroblast growth factor receptor binding GO:0005104
Interacting selectively and non-covalently with the fibroblast growth factor receptor (FGFR).
|
2 | P13596 (/TAS) P13596 (/TAS) |
Cytoskeletal protein binding GO:0008092
Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).
|
2 | P13596 (/TAS) P13596 (/TAS) |
Phosphatase binding GO:0019902
Interacting selectively and non-covalently with any phosphatase.
|
2 | P13596 (/IDA) P13596 (/IDA) |
LRR domain binding GO:0030275
Interacting selectively and non-covalently with a LRR domain (leucine rich repeats) of a protein.
|
2 | P13596 (/IPI) P13596 (/IPI) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
2 | P13595 (/ISO) P13595 (/ISO) |
Ras guanyl-nucleotide exchange factor activity GO:0005088
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
1 | P13591 (/TAS) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | P13591 (/IPI) |
There are 32 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
|
5 | P13591 (/TAS) P13595 (/TAS) P13595 (/TAS) P13596 (/TAS) P13596 (/TAS) |
Regulation of exocyst assembly GO:0001928
Any process that modulates the frequency, rate or extent of exocyst assembly.
|
2 | P13595 (/IMP) P13595 (/IMP) |
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
|
2 | P13596 (/TAS) P13596 (/TAS) |
Homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156
The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
|
2 | P13590 (/IMP) P13590 (/IMP) |
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
|
2 | P13595 (/IDA) P13595 (/IDA) |
Axonal fasciculation GO:0007413
The collection of axons into a bundle of rods, known as a fascicle.
|
2 | P13596 (/IMP) P13596 (/IMP) |
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
|
2 | P13596 (/IDA) P13596 (/IDA) |
Learning or memory GO:0007611
The acquisition and processing of information and/or the storage and retrieval of this information over time.
|
2 | P13596 (/IDA) P13596 (/IDA) |
Learning or memory GO:0007611
The acquisition and processing of information and/or the storage and retrieval of this information over time.
|
2 | P13596 (/IMP) P13596 (/IMP) |
Response to inorganic substance GO:0010035
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus.
|
2 | P13596 (/IEP) P13596 (/IEP) |
Response to lead ion GO:0010288
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus.
|
2 | P13596 (/IDA) P13596 (/IDA) |
Peripheral nervous system axon regeneration GO:0014012
The regrowth of axons outside the central nervous system (outside the brain and spinal cord) following an axonal injury.
|
2 | P13596 (/IEP) P13596 (/IEP) |
Response to activity GO:0014823
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus.
|
2 | P13596 (/IEP) P13596 (/IEP) |
Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules GO:0016338
The attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction.
|
2 | P13596 (/TAS) P13596 (/TAS) |
Thalamus development GO:0021794
The process in which the thalamus changes over time, from its initial formation to its mature state.
|
2 | P13596 (/IDA) P13596 (/IDA) |
Extracellular matrix organization GO:0030198
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
|
2 | P13590 (/TAS) P13590 (/TAS) |
Animal organ regeneration GO:0031100
The regrowth of a lost or destroyed animal organ.
|
2 | P13596 (/IEP) P13596 (/IEP) |
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
2 | P13595 (/IGI) P13595 (/IGI) |
Multicellular organismal response to stress GO:0033555
Any process that results in a change in state or activity of a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
|
2 | P13596 (/IDA) P13596 (/IDA) |
Homotypic cell-cell adhesion GO:0034109
The attachment of a cell to a second cell of the identical type via adhesion molecules.
|
2 | P13595 (/IMP) P13595 (/IMP) |
Response to cocaine GO:0042220
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant.
|
2 | P13596 (/IDA) P13596 (/IDA) |
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
|
2 | P13596 (/IDA) P13596 (/IDA) |
Neuron development GO:0048666
The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.
|
2 | P13596 (/IDA) P13596 (/IDA) |
Positive regulation of calcium-mediated signaling GO:0050850
Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling.
|
2 | P13595 (/IDA) P13595 (/IDA) |
Regulation of sensory perception of pain GO:0051930
Any process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal.
|
2 | P13596 (/IMP) P13596 (/IMP) |
Positive regulation of cardiac muscle cell proliferation GO:0060045
Any process that activates or increases the frequency, rate or extent of cardiac muscle cell proliferation.
|
2 | P13596 (/IMP) P13596 (/IMP) |
Negative regulation of cell death GO:0060548
Any process that decreases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death.
|
2 | P13596 (/IMP) P13596 (/IMP) |
Cellular response to molecule of bacterial origin GO:0071219
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin.
|
2 | P13596 (/IEP) P13596 (/IEP) |
Cellular response to inorganic substance GO:0071241
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus.
|
2 | P13596 (/IEP) P13596 (/IEP) |
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
|
1 | P13591 (/TAS) |
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
|
1 | P13591 (/NAS) |
Interferon-gamma-mediated signaling pathway GO:0060333
A series of molecular signals initiated by the binding of interferon-gamma to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon gamma is the only member of the type II interferon found so far.
|
1 | P13591 (/TAS) |
There are 21 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
8 | A0A087WTE4 (/IDA) A0A087WTF6 (/IDA) A0A087WV75 (/IDA) A0A087WVU1 (/IDA) A0A087WWD4 (/IDA) A0A087WX77 (/IDA) H7BYX6 (/IDA) P13591 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
8 | A0A087WTE4 (/IDA) A0A087WTF6 (/IDA) A0A087WV75 (/IDA) A0A087WVU1 (/IDA) A0A087WWD4 (/IDA) A0A087WX77 (/IDA) H7BYX6 (/IDA) P13591 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
7 | P13590 (/TAS) P13590 (/TAS) P13591 (/TAS) P13595 (/TAS) P13595 (/TAS) P13596 (/TAS) P13596 (/TAS) |
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
|
4 | P13595 (/IDA) P13595 (/IDA) P13596 (/IDA) P13596 (/IDA) |
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
3 | P13591 (/IDA) P13595 (/IDA) P13595 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | P13595 (/ISO) P13595 (/ISO) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | P13595 (/ISO) P13595 (/ISO) |
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
|
2 | P13595 (/IDA) P13595 (/IDA) |
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
2 | P13595 (/ISO) P13595 (/ISO) |
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
2 | P13595 (/ISO) P13595 (/ISO) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
2 | P13595 (/ISO) P13595 (/ISO) |
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
|
2 | P13595 (/IDA) P13595 (/IDA) |
Growth cone GO:0030426
The migrating motile tip of a growing nerve cell axon or dendrite.
|
2 | P13595 (/IDA) P13595 (/IDA) |
Growth cone GO:0030426
The migrating motile tip of a growing nerve cell axon or dendrite.
|
2 | P13596 (/TAS) P13596 (/TAS) |
Myelin sheath GO:0043209
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
|
2 | P13595 (/IDA) P13595 (/IDA) |
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
2 | P13595 (/ISO) P13595 (/ISO) |
Golgi membrane GO:0000139
The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
|
1 | P13591 (/TAS) |
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
|
1 | P13591 (/IDA) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | P13591 (/IDA) |
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | P13591 (/TAS) |
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | P13591 (/IDA) |