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CATH Superfamily 2.60.120.260

Galactose-binding domain-like

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Galactose-binding domain-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 35692: Signal peptide protein, YSIRK family

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Endo-alpha-N-acetylgalactosaminidase. [EC: 3.2.1.97]
3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosaminyl-L-serine-[protein] + H(2)O = 3-O-beta-D-galactosyl-N-acetyl-alpha-D-galactosamine + L-serine-[protein].
  • The enzyme catalyzes the liberation of Gal-(1->3)-beta-GalNAc alpha- linked to serine or threonine residues of mucin-type glycoproteins.
  • EngBF from Bifidobacterium longum specifically acts on core 1-type O-glycan to release the disaccharide Gal-(1->3)-beta-GalNAc.
  • The enzymes from Clostridium perfringens, Enterococcus faecalis, Propionibacterium acnes and Alcaligenes faecalis show broader specificity (e.g. release of the core 2 trisaccharide Gal-(1->3)- beta-(GlcNAc-(1->6)-beta)-GalNAc or the core 3 disaccharide GlcNAc- (1->3)-beta-GalNAc).
  • The enzyme may play an important role in the degradation and utilization of mucins having core 1 O-glycan.
  • Formerly EC 3.2.1.110.
 90 A0A0E8TCR1 A0A0E9GZH9 A0A0H2ZM17 A0A0T7IBI0 A0A0T7J2P2 A0A0T7JU76 A0A0T7TBH2 A0A0T7YHZ6 A0A0T7ZMV8 A0A0T8ACE2
(80 more...)
Exo-alpha-sialidase. [EC: 3.2.1.18]
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
  • The enzyme does not act on 4-O-acetylated sialic acids.
  • An endo-alpha-sialidase activity is listed as EC 3.2.1.129.
  • See also EC 4.2.2.15.
 1 P29767
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