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CATH Superfamily 2.60.120.260

Galactose-binding domain-like

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Galactose-binding domain-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 35529: Proprotein convertase subtilisin/kexin type 5

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Proprotein convertase 2. [EC: 3.4.21.94]
Release of protein hormones and neuropeptides from their precursors, generally by hydrolysis of -Lys-Arg-|- bonds.
  • A calcium dependent enzyme, maximally active at about pH 5.5.
  • Specificity is broader than that of prohormone convertase 1.
  • Substrates include pro-opiomelanocortin, proenkephalin, prodynorphin, proinsulin and proluteinizing-hormone-releasing hormone.
  • Unlike prohormone convertase 1, does not cleave prorenin or prosomatostatin.
  • Usually processing of prodynorphin occurs at a bond in which P2 is Thr.
  • Present in the regulated secretory pathway of neuroendocrine cells, commonly actin co-operatively with prohormone convertase 1.
  • Belongs to peptidase family S8.
 28 A1IHD0 A1IHD0 B2ZRZ7 B2ZRZ7 B7Q266 B7Q266 E0VP88 E0VP88 G3QWE4 G3QWE4
(18 more...)
Furin. [EC: 3.4.21.75]
Release of mature proteins from their proproteins by cleavage of -Arg- Xaa-Yaa-Arg-|-Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.
  • Activated by calcium.
  • Belongs to peptidase family S8.
 28 A0A024RC70 A0A024RC70 B7PMP4 B7PMP4 B7PPF6 B7PPF6 E0V9N9 E0V9N9 E0VJJ2 E0VJJ2
(18 more...)
Proprotein convertase 1. [EC: 3.4.21.93]
Release of protein hormones, neuropeptides and renin from their precursors, generally by hydrolysis of -Lys-Arg-|- bonds.
  • A calcium dependent enzyme, maximally active at about pH 5.5.
  • Substrates include pro-opiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and proinsulin.
  • Unlike prohormone convertase 2, does not cleave proluteinizing- hormone-releasing hormone.
  • Usually processing of prodynorphin occurs at a bond in which P2 is Thr.
  • Present in the regulated secretory pathway of neuroendocrine cells, commonly actin co-operatively with prohormone convertase 2.
  • Belongs to peptidase family S8.
 12 P28840 P28840 P29120 P29120 P63239 P63239 P63240 P63240 Q32MU0 Q32MU0
(2 more...)
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