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CATH Superfamily 2.40.33.20

PK beta-barrel domain-like

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
PK beta-barrel domain-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2478: Molybdenum cofactor sulfurase, putative

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Molybdenum cofactor sulfurtransferase. [EC: 2.8.1.9]
Molybdenum cofactor + L-cysteine + reduced acceptor + 2 H(+) = thio- molybdenum cofactor + L-alanine + H(2)O + oxidized acceptor.
  • Replaces the equatorial oxo ligand of the molybdenum by sulfur via an enzyme-bound persulfide.
  • The reaction occurs in prokaryotes and eukaryotes but MoCo sulfurtransferases are only found in eukaryotes.
  • In prokaryotes the reaction is catalyzed by two enzymes: EC 2.8.1.7, which is homologous to the N-terminus of eukaryotic MoCo sulfurtransferases, and a molybdo-enzyme specific chaperone which binds the MoCo and acts as an adapter protein.
 14 A0A0L0C215 B3MZN7 B4H0S8 B4L340 B4M3C6 B4M3C9 F1PDQ7 F7BDB2 G3T425 L8IWU4
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