The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 415: Carboxyl-terminal PDZ ligand of neuronal nitric ox...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nitric-oxide synthase binding GO:0050998
Interacting selectively and non-covalently with the enzyme nitric-oxide synthase.
3 H0VD63 (/IPI) O54960 (/IPI) Q9D3A8 (/IPI)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 O54960 (/IPI) O75052 (/IPI)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
1 O54960 (/IPI)
PDZ domain binding GO:0030165
Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.
1 O54960 (/IDA)
Nitric-oxide synthase binding GO:0050998
Interacting selectively and non-covalently with the enzyme nitric-oxide synthase.
1 O54960 (/IDA)
Nitric-oxide synthase binding GO:0050998
Interacting selectively and non-covalently with the enzyme nitric-oxide synthase.
1 O75052 (/ISS)

There are 41 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307
Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in a ventricular cardiomyocyte.
2 H0VD63 (/IMP) O75052 (/IMP)
Regulation of heart rate by chemical signal GO:0003062
The regulation of the rate of heart contraction mediated by chemical signaling, hormonal, autocrine or paracrine.
1 O75052 (/IMP)
Neurotransmitter secretion GO:0007269
The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium regualated exocytosis during synaptic transmission.
1 O54960 (/NAS)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 H0VD63 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 O75052 (/ISS)
Positive regulation of nitric oxide mediated signal transduction GO:0010750
Any process that increases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO).
1 H0VD63 (/IMP)
Positive regulation of nitric oxide mediated signal transduction GO:0010750
Any process that increases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO).
1 O75052 (/ISS)
Neuron projection regeneration GO:0031102
The regrowth of neuronal processes such as axons or dendrites in response to their loss or damage.
1 O54960 (/IEP)
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
1 O75052 (/NAS)
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
1 O54960 (/TAS)
Regulation of nitric oxide biosynthetic process GO:0045428
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
1 O75052 (/NAS)
Regulation of nitric oxide biosynthetic process GO:0045428
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
1 O54960 (/TAS)
Positive regulation of nitric oxide biosynthetic process GO:0045429
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
1 H0VD63 (/IMP)
Positive regulation of nitric oxide biosynthetic process GO:0045429
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide.
1 O75052 (/ISS)
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
1 H0VD63 (/IC)
Regulation of nitric-oxide synthase activity GO:0050999
Any process that modulates the activity of the enzyme nitric-oxide synthase.
1 O54960 (/IC)
Regulation of nitric-oxide synthase activity GO:0050999
Any process that modulates the activity of the enzyme nitric-oxide synthase.
1 O75052 (/NAS)
Regulation of nitric-oxide synthase activity GO:0050999
Any process that modulates the activity of the enzyme nitric-oxide synthase.
1 O54960 (/TAS)
Positive regulation of nitric-oxide synthase activity GO:0051000
Any process that activates or increases the activity of the enzyme nitric-oxide synthase.
1 H0VD63 (/IMP)
Positive regulation of nitric-oxide synthase activity GO:0051000
Any process that activates or increases the activity of the enzyme nitric-oxide synthase.
1 O75052 (/ISS)
Regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307
Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in a ventricular cardiomyocyte.
1 O75052 (/ISS)
Regulation of cardiac muscle cell action potential GO:0098901
Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.
1 O54960 (/IC)
Regulation of cardiac muscle cell action potential GO:0098901
Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.
1 H0VD63 (/IMP)
Regulation of cardiac muscle cell action potential GO:0098901
Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.
1 O75052 (/ISS)
Regulation of cardiac muscle cell action potential GO:0098901
Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination in a cardiac muscle cell. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.
1 O75052 (/TAS)
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
1 O54960 (/IMP)
Positive regulation of potassium ion transmembrane transport GO:1901381
Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transport.
1 H0VD63 (/IMP)
Positive regulation of potassium ion transmembrane transport GO:1901381
Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transport.
1 O75052 (/ISS)
Regulation of high voltage-gated calcium channel activity GO:1901841
Any process that modulates the frequency, rate or extent of high voltage-gated calcium channel activity.
1 O54960 (/IDA)
Regulation of high voltage-gated calcium channel activity GO:1901841
Any process that modulates the frequency, rate or extent of high voltage-gated calcium channel activity.
1 H0VD63 (/IMP)
Regulation of high voltage-gated calcium channel activity GO:1901841
Any process that modulates the frequency, rate or extent of high voltage-gated calcium channel activity.
1 O75052 (/ISS)
Positive regulation of delayed rectifier potassium channel activity GO:1902261
Any process that activates or increases the frequency, rate or extent of delayed rectifier potassium channel activity.
1 H0VD63 (/IMP)
Positive regulation of delayed rectifier potassium channel activity GO:1902261
Any process that activates or increases the frequency, rate or extent of delayed rectifier potassium channel activity.
1 O75052 (/ISS)
Regulation of calcium ion transmembrane transport via high voltage-gated calcium channel GO:1902514
Any process that modulates the frequency, rate or extent of generation of calcium ion transmembrane transport via high voltage-gated calcium channel.
1 O54960 (/IC)
Regulation of calcium ion transmembrane transport via high voltage-gated calcium channel GO:1902514
Any process that modulates the frequency, rate or extent of generation of calcium ion transmembrane transport via high voltage-gated calcium channel.
1 H0VD63 (/IMP)
Regulation of calcium ion transmembrane transport via high voltage-gated calcium channel GO:1902514
Any process that modulates the frequency, rate or extent of generation of calcium ion transmembrane transport via high voltage-gated calcium channel.
1 O75052 (/ISS)
Regulation of calcium ion transmembrane transport via high voltage-gated calcium channel GO:1902514
Any process that modulates the frequency, rate or extent of generation of calcium ion transmembrane transport via high voltage-gated calcium channel.
1 O75052 (/TAS)
Positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization GO:1903762
Any process that activates or increases the frequency, rate or extent of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization.
1 H0VD63 (/IMP)
Positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization GO:1903762
Any process that activates or increases the frequency, rate or extent of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization.
1 O75052 (/ISS)
Positive regulation of peptidyl-cysteine S-nitrosylation GO:2000170
Any process that activates or increases the frequency, rate or extent of peptidyl-cysteine S-nitrosylation.
1 O54960 (/IMP)
Positive regulation of peptidyl-cysteine S-nitrosylation GO:2000170
Any process that activates or increases the frequency, rate or extent of peptidyl-cysteine S-nitrosylation.
1 O75052 (/ISS)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 O54960 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 O75052 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 O54960 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 O54960 (/NAS)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 Q9D3A8 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
1 O75052 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O54960 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 O75052 (/ISS)
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
1 Q9D3A8 (/IDA)
Z disc GO:0030018
Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached.
1 O75052 (/ISS)
Sarcoplasmic reticulum membrane GO:0033017
The lipid bilayer surrounding the sarcoplasmic reticulum.
1 Q9D3A8 (/IDA)
Sarcoplasmic reticulum membrane GO:0033017
The lipid bilayer surrounding the sarcoplasmic reticulum.
1 O75052 (/ISS)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 H0VD63 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 O75052 (/ISS)
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