CATH Superfamily 2.30.29.30
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".
FunFam 22686: Rho GTPase-activating protein 25
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 17 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
5 | Q7Z5H3 (/IPI) Q8C115 (/IPI) Q8IVE3 (/IPI) Q8N264 (/IPI) Q9UN19 (/IPI) |
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
|
3 | P42331 (/TAS) Q7Z5H3 (/TAS) Q8N264 (/TAS) |
Phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547
Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions.
|
2 | Q86IV4 (/IDA) Q9UN19 (/IDA) |
Sterol 3-beta-glucosyltransferase activity GO:0016906
Catalysis of the reaction: UDP-glucose + a sterol = UDP + an O-glucosylsterol.
|
2 | Q06321 (/IDA) Q5A950 (/IDA) |
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
|
1 | Q8C115 (/IDA) |
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
|
1 | Q8IVE3 (/ISS) |
GTPase activator activity GO:0005096
Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
|
1 | Q8C4V1 (/IMP) |
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
|
1 | Q9UN19 (/NAS) |
Phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547
Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions.
|
1 | Q9QXT1 (/ISO) |
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | Q8C115 (/IPI) |
Phosphatidylinositol-3,4-bisphosphate binding GO:0043325
Interacting selectively and non-covalently with phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions.
|
1 | Q9UN19 (/IDA) |
Phosphatidylinositol-3,4-bisphosphate binding GO:0043325
Interacting selectively and non-covalently with phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions.
|
1 | Q9QXT1 (/ISO) |
Cholesterol UDP-glucosyltransferase activity GO:0051505
Catalysis of the reaction: UDP-glucose + a sterol = UDP + O-glucosyl-cholesterol.
|
1 | Q54IL5 (/IDA) |
Ergosterol UDP-glucosyltransferase activity GO:0051506
Catalysis of the reaction: UDP-glucose + a sterol = UDP + O-glucosyl-ergosterol.
|
1 | Q54IL5 (/IDA) |
Beta-sitosterol UDP-glucosyltransferase activity GO:0051507
Catalysis of the reaction: UDP-glucose + a sterol = UDP + O-glucosyl-beta-sitosterol.
|
1 | Q54IL5 (/IDA) |
Stigmasterol UDP-glucosyltransferase activity GO:0051508
Catalysis of the reaction: UDP-glucose + a sterol = UDP + O-glucosyl-stigmasterol.
|
1 | Q54IL5 (/IDA) |
Tomatidine UDP-glucosyltransferase activity GO:0051509
Catalysis of the reaction: UDP-glucose + a sterol = UDP + O-glucosyl-tomatidine.
|
1 | Q54IL5 (/IDA) |
There are 14 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Regulation of small GTPase mediated signal transduction GO:0051056
Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.
|
3 | P42331 (/TAS) Q7Z5H3 (/TAS) Q8N264 (/TAS) |
Branching involved in blood vessel morphogenesis GO:0001569
The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system.
|
1 | Q00IB7 (/IMP) |
Protein dephosphorylation GO:0006470
The process of removing one or more phosphoric residues from a protein.
|
1 | Q9UN19 (/NAS) |
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
|
1 | Q9UN19 (/TAS) |
Sterol metabolic process GO:0016125
The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
|
1 | Q54IL5 (/IDA) |
Sterol metabolic process GO:0016125
The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
|
1 | Q06321 (/IMP) |
Negative regulation of actin filament depolymerization GO:0030835
Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization.
|
1 | Q8C115 (/IDA) |
Negative regulation of actin filament depolymerization GO:0030835
Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization.
|
1 | Q8IVE3 (/ISS) |
Ascospore-type prospore membrane assembly GO:0032120
The process in which the nascent membrane forms at the meiotic outer plaque and grows until closure occurs and forespores, or prospores, are formed.
|
1 | Q06321 (/IGI) |
Negative regulation of Rac protein signal transduction GO:0035021
Any process that stops, prevents, or reduces the frequency, rate or extent of Rac protein signal transduction.
|
1 | Q8C4V1 (/IMP) |
Wound healing, spreading of epidermal cells GO:0035313
The migration of an epidermal cell along or through a wound gap that contributes to the reestablishment of a continuous epidermis.
|
1 | Q8C4V1 (/IMP) |
Blood vessel morphogenesis GO:0048514
The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood.
|
1 | Q00IB7 (/IMP) |
Activation of GTPase activity GO:0090630
Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
|
1 | Q8C4V1 (/IMP) |
Negative regulation of ruffle assembly GO:1900028
Any process that stops, prevents or reduces the frequency, rate or extent of ruffle assembly.
|
1 | Q8C4V1 (/IMP) |
There are 17 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
4 | P42331 (/TAS) Q7Z5H3 (/TAS) Q8N264 (/TAS) Q9UN19 (/TAS) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
3 | Q86IV4 (/IDA) Q8IVE3 (/IDA) Q9UN19 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | Q8C115 (/ISO) Q9QXT1 (/ISO) |
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
2 | Q7Z5H3 (/IDA) Q8C4V1 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q8IVE3 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q8C115 (/ISO) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q8C115 (/ISS) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q86IV4 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q8C115 (/ISS) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q9UN19 (/TAS) |
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
1 | Q8BL80 (/ISO) |
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
|
1 | Q8IVE3 (/IDA) |
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
|
1 | Q8C115 (/ISO) |
Lamellipodium GO:0030027
A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments.
|
1 | Q8C115 (/ISS) |
Cortical actin cytoskeleton GO:0030864
The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
|
1 | Q8C115 (/IDA) |
Cortical actin cytoskeleton GO:0030864
The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.
|
1 | Q8IVE3 (/ISS) |
Cell leading edge GO:0031252
The area of a motile cell closest to the direction of movement.
|
1 | Q86IV4 (/IDA) |