CATH Superfamily 2.30.29.30
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".
FunFam 22631: Rho guanine nucleotide exchange factor 5
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 19 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Rho guanyl-nucleotide exchange factor activity GO:0005089
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
18 |
E1BDY4 (/ISS)
F6V5A2 (/ISS)
F6VCK1 (/ISS)
F7IL25 (/ISS)
F7IQR9 (/ISS)
G1L6T3 (/ISS)
G1PAW4 (/ISS)
G1RG00 (/ISS)
G1TQ06 (/ISS)
G3R8J7 (/ISS)
(8 more) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
9 | A0A0G2JTU0 (/IPI) D3DTR7 (/IPI) E9Q7D5 (/IPI) O94989 (/IPI) Q12774 (/IPI) Q5FWH6 (/IPI) Q5VV41 (/IPI) Q8CHT1 (/IPI) Q8IW93 (/IPI) |
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
5 | Q12774 (/TAS) Q5VV41 (/TAS) Q8IW93 (/TAS) Q8N5V2 (/TAS) Q96DR7 (/TAS) |
Rho guanyl-nucleotide exchange factor activity GO:0005089
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
5 | Q12774 (/TAS) Q5VV41 (/TAS) Q8IW93 (/TAS) Q8N5V2 (/TAS) Q96DR7 (/TAS) |
Rho guanyl-nucleotide exchange factor activity GO:0005089
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
3 | O94989 (/IDA) Q5FWH6 (/IDA) Q5VV41 (/IDA) |
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
2 | E9Q7D5 (/ISO) Q8CHT1 (/ISO) |
Rho guanyl-nucleotide exchange factor activity GO:0005089
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
2 | Q3U5C8 (/ISO) Q5FWH6 (/ISO) |
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
1 | Q8N5V2 (/EXP) |
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
|
1 | Q12774 (/IDA) |
GTP binding GO:0005525
Interacting selectively and non-covalently with GTP, guanosine triphosphate.
|
1 | Q12774 (/TAS) |
Rho GTPase binding GO:0017048
Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton.
|
1 | Q5VV41 (/IPI) |
Rho GTPase binding GO:0017048
Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton.
|
1 | Q3U5C8 (/ISO) |
PDZ domain binding GO:0030165
Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.
|
1 | Q5VV41 (/IPI) |
PDZ domain binding GO:0030165
Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.
|
1 | Q3U5C8 (/ISO) |
Receptor tyrosine kinase binding GO:0030971
Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.
|
1 | Q5VV41 (/IPI) |
Receptor tyrosine kinase binding GO:0030971
Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity.
|
1 | Q3U5C8 (/ISO) |
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
|
1 | Q5VV41 (/IDA) |
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
|
1 | Q3U5C8 (/ISO) |
Ephrin receptor binding GO:0046875
Interacting selectively and non-covalently with an ephrin receptor.
|
1 | Q8CHT1 (/IPI) |
There are 50 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Positive regulation of stress fiber assembly GO:0051496
Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
|
18 |
E1BDY4 (/ISS)
F6V5A2 (/ISS)
F6VCK1 (/ISS)
F7IL25 (/ISS)
F7IQR9 (/ISS)
G1L6T3 (/ISS)
G1PAW4 (/ISS)
G1RG00 (/ISS)
G1TQ06 (/ISS)
G3R8J7 (/ISS)
(8 more) |
Regulation of catalytic activity GO:0050790
Any process that modulates the activity of an enzyme.
|
17 |
E1BDY4 (/ISS)
F6V5A2 (/ISS)
F6VCK1 (/ISS)
F7IL25 (/ISS)
F7IQR9 (/ISS)
G1L6T3 (/ISS)
G1PAW4 (/ISS)
G1RG00 (/ISS)
G1TQ06 (/ISS)
G3R8J7 (/ISS)
(7 more) |
Negative regulation of synapse maturation GO:2000297
Any process that stops, prevents or reduces the frequency, rate or extent of synapse maturation.
|
16 |
E1BDY4 (/ISS)
F6V5A2 (/ISS)
F6VCK1 (/ISS)
F7IL25 (/ISS)
G1L6T3 (/ISS)
G1PAW4 (/ISS)
G1RG00 (/ISS)
G1TQ06 (/ISS)
G3R8J7 (/ISS)
G3SQE5 (/ISS)
(6 more) |
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
|
5 | Q12774 (/TAS) Q5VV41 (/TAS) Q8IW93 (/TAS) Q8N5V2 (/TAS) Q96DR7 (/TAS) |
Regulation of small GTPase mediated signal transduction GO:0051056
Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction.
|
5 | Q12774 (/TAS) Q5VV41 (/TAS) Q8IW93 (/TAS) Q8N5V2 (/TAS) Q96DR7 (/TAS) |
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
|
3 | Q5BKC9 (/ISS) Q5RDX5 (/ISS) Q8N5V2 (/ISS) |
Ephrin receptor signaling pathway GO:0048013
The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.
|
3 | Q5BKC9 (/ISS) Q5RDX5 (/ISS) Q8N5V2 (/ISS) |
Ephrin receptor signaling pathway GO:0048013
The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.
|
3 | Q5I1Y9 (/TAS) Q8CHT1 (/TAS) Q8N5V2 (/TAS) |
Negative regulation of dendritic spine morphogenesis GO:0061002
Any process that decreases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
|
3 | Q5BKC9 (/ISS) Q5RDX5 (/ISS) Q8N5V2 (/ISS) |
Endothelial cell morphogenesis GO:0001886
The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell.
|
2 | D3YYY8 (/IMP) F6TAL7 (/IMP) |
Regulation of actin cytoskeleton organization GO:0032956
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
|
2 | E9Q7D5 (/ISO) Q8BWA8 (/ISO) |
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
|
2 | Q12774 (/IDA) Q8CHT1 (/IDA) |
Ruffle assembly GO:0097178
The aggregation, arrangement and bonding together of a set of components to form a ruffle, a projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. The formation of ruffles (also called membrane ruffling) is thought to be controlled by a group of enzymes known as Rho GTPases, specifically RhoA, Rac1 and cdc42.
|
2 | D3YYY8 (/IMP) F6TAL7 (/IMP) |
Myeloid dendritic cell chemotaxis GO:0002408
The movement of a myeloid dendritic cell in response to an external stimulus.
|
1 | E9Q7D5 (/IMP) |
Cellular process GO:0009987
Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
|
1 | Q8CHT1 (/IDA) |
Actin cytoskeleton organization GO:0030036
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
|
1 | E9Q7D5 (/IDA) |
Regulation of actin cytoskeleton organization GO:0032956
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
|
1 | Q8IW93 (/IGI) |
Regulation of actin cytoskeleton organization GO:0032956
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
|
1 | Q12774 (/IMP) |
Wound healing GO:0042060
The series of events that restore integrity to a damaged tissue, following an injury.
|
1 | Q8BWA8 (/IMP) |
Regulation of GTPase activity GO:0043087
Any process that modulates the rate of GTP hydrolysis by a GTPase.
|
1 | E9Q7D5 (/ISO) |
Positive regulation of JUN kinase activity GO:0043507
Any process that activates or increases the frequency, rate or extent of JUN kinase activity.
|
1 | Q12774 (/IDA) |
Positive regulation of JUN kinase activity GO:0043507
Any process that activates or increases the frequency, rate or extent of JUN kinase activity.
|
1 | E9Q7D5 (/ISO) |
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
|
1 | E9Q7D5 (/IDA) |
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
|
1 | Q8BWA8 (/IGI) |
Ephrin receptor signaling pathway GO:0048013
The series of molecular signals generated as a consequence of an ephrin receptor binding to an ephrin.
|
1 | Q8CHT1 (/IDA) |
Regulation of catalytic activity GO:0050790
Any process that modulates the activity of an enzyme.
|
1 | O94989 (/IDA) |
Regulation of catalytic activity GO:0050790
Any process that modulates the activity of an enzyme.
|
1 | Q5FWH6 (/ISO) |
Positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
1 | Q12774 (/IDA) |
Positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
|
1 | E9Q7D5 (/ISO) |
Regulation of cytoskeleton organization GO:0051493
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.
|
1 | Q12774 (/IMP) |
Regulation of cytoskeleton organization GO:0051493
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures.
|
1 | E9Q7D5 (/ISO) |
Positive regulation of stress fiber assembly GO:0051496
Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
|
1 | Q12774 (/IMP) |
Positive regulation of stress fiber assembly GO:0051496
Any process that activates or increases the frequency, rate or extent of the assembly of a stress fiber, a bundle of microfilaments and other proteins found in fibroblasts.
|
1 | E9Q7D5 (/ISO) |
Wnt signaling pathway, planar cell polarity pathway GO:0060071
The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity.
|
1 | Q8IW93 (/NAS) |
Cell chemotaxis GO:0060326
The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
|
1 | Q5VV41 (/IMP) |
Cell chemotaxis GO:0060326
The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
|
1 | Q3U5C8 (/ISO) |
Cell chemotaxis GO:0060326
The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
|
1 | Q3U5C8 (/ISS) |
Negative regulation of dendritic spine morphogenesis GO:0061002
Any process that decreases the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission.
|
1 | Q8CHT1 (/IDA) |
Retina vasculature morphogenesis in camera-type eye GO:0061299
The process in which the vasculature of the retina is generated and organized.
|
1 | Q5FWH6 (/IMP) |
Positive regulation of podosome assembly GO:0071803
Any process that activates or increases the rate or extent of podosome assembly.
|
1 | E9Q7D5 (/IGI) |
Positive regulation of establishment of protein localization to plasma membrane GO:0090004
Any process that increases the frequency, rate or extent of the directed movement of a protein to a specific location in the plasma membrane.
|
1 | Q5VV41 (/IMP) |
Positive regulation of establishment of protein localization to plasma membrane GO:0090004
Any process that increases the frequency, rate or extent of the directed movement of a protein to a specific location in the plasma membrane.
|
1 | Q3U5C8 (/ISO) |
Positive regulation of establishment of protein localization to plasma membrane GO:0090004
Any process that increases the frequency, rate or extent of the directed movement of a protein to a specific location in the plasma membrane.
|
1 | Q3U5C8 (/ISS) |
Activation of GTPase activity GO:0090630
Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
|
1 | Q5VV41 (/IDA) |
Activation of GTPase activity GO:0090630
Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
|
1 | Q5VV41 (/IMP) |
Activation of GTPase activity GO:0090630
Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
|
1 | Q3U5C8 (/ISO) |
Activation of GTPase activity GO:0090630
Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.
|
1 | Q3U5C8 (/ISS) |
Positive regulation of protein import GO:1904591
Any process that activates or increases the frequency, rate or extent of protein import.
|
1 | Q12774 (/IMP) |
Positive regulation of protein import GO:1904591
Any process that activates or increases the frequency, rate or extent of protein import.
|
1 | E9Q7D5 (/ISO) |
Negative regulation of synapse maturation GO:2000297
Any process that stops, prevents or reduces the frequency, rate or extent of synapse maturation.
|
1 | Q5FWH6 (/IMP) |
There are 16 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
18 |
E1BDY4 (/ISS)
F6V5A2 (/ISS)
F6VCK1 (/ISS)
F7IL25 (/ISS)
F7IQR9 (/ISS)
G1L6T3 (/ISS)
G1PAW4 (/ISS)
G1RG00 (/ISS)
G1TQ06 (/ISS)
G3R8J7 (/ISS)
(8 more) |
Dendrite GO:0030425
A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
|
16 |
E1BDY4 (/ISS)
F6V5A2 (/ISS)
F6VCK1 (/ISS)
F7IL25 (/ISS)
G1L6T3 (/ISS)
G1PAW4 (/ISS)
G1RG00 (/ISS)
G1TQ06 (/ISS)
G3R8J7 (/ISS)
G3SQE5 (/ISS)
(6 more) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
7 | Q12774 (/TAS) Q5I1Y9 (/TAS) Q5VV41 (/TAS) Q8CHT1 (/TAS) Q8IW93 (/TAS) Q8N5V2 (/TAS) Q96DR7 (/TAS) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
2 | A0A090N7S2 (/IDA) Q12774 (/IDA) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
2 | A0A090N7S2 (/IDA) Q12774 (/IDA) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | A0A090N7S2 (/IDA) Q12774 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | Q12774 (/IDA) |
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
1 | E9Q7D5 (/ISO) |
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | E9Q7D5 (/ISO) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q12774 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | E9Q7D5 (/ISO) |
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | E9Q7D5 (/ISO) |
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | E9Q7D5 (/ISO) |
Dendrite GO:0030425
A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
|
1 | Q5FWH6 (/IDA) |
Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
|
1 | Q12774 (/IDA) |
Cell periphery GO:0071944
The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures.
|
1 | E9Q7D5 (/ISO) |