The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 22580: Actin-binding protein anillin

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
2 Q9NQW6 (/IDA) Q9V4P1 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q9NQW6 (/IPI) Q9V4P1 (/IPI)
Microtubule binding GO:0008017
Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers.
2 Q9V4P1 (/IDA) Q9XTT4 (/IDA)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
1 Q8K298 (/ISO)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
1 Q9V4P1 (/ISS)
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
1 Q9NQW6 (/TAS)
Myosin binding GO:0017022
Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments.
1 Q9V4P1 (/IDA)
GTP-Rho binding GO:0017049
Interacting selectively and non-covalently with the GTP-bound form of the Rho protein.
1 Q9XTT4 (/IPI)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
1 Q9NQW6 (/IDA)
Cadherin binding GO:0045296
Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion.
1 Q8K298 (/ISO)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
1 Q9V4P1 (/IDA)
Actin filament binding GO:0051015
Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits.
1 Q9XTT4 (/ISS)

There are 39 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Asymmetric cell division GO:0008356
The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity.
4 A4IFW5 (/IMP) F1QJH8 (/IMP) Q1LUB2 (/IMP) Q9V4P1 (/IMP)
Glomerular filtration GO:0003094
The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein.
3 A4IFW5 (/IMP) F1QJH8 (/IMP) Q1LUB2 (/IMP)
Glomerular basement membrane development GO:0032836
The process whose specific outcome is the progression of the glomerular basement membrane over time, from its formation to the mature structure. The glomerular basement membrane is the basal laminal portion of the glomerulus which performs the actual filtration.
3 A4IFW5 (/IMP) F1QJH8 (/IMP) Q1LUB2 (/IMP)
Glomerular visceral epithelial cell development GO:0072015
The process whose specific outcome is the progression of a glomerular visceral epithelial cell over time, from its formation to the mature structure. A glomerular visceral epithelial cell is a specialized epithelial cell that contains \feet\ that interdigitate with the \feet\ of other glomerular epithelial cells.
3 A4IFW5 (/IMP) F1QJH8 (/IMP) Q1LUB2 (/IMP)
Protein localization GO:0008104
Any process in which a protein is transported to, or maintained in, a specific location.
2 Q9V4P1 (/IMP) Q9XTT4 (/IMP)
Septin ring organization GO:0031106
Control of the formation, spatial distribution, and breakdown of the septin ring.
2 Q9V4P1 (/IMP) Q9XTT4 (/IMP)
Positive regulation of bleb assembly GO:1904172
Any process that activates or increases the frequency, rate or extent of bleb assembly.
2 Q801E2 (/ISS) Q8K298 (/ISS)
Mitotic cytokinesis GO:0000281
A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
1 Q9NQW6 (/IDA)
Mitotic cytokinesis GO:0000281
A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
1 Q9V4P1 (/IMP)
Mitotic cytokinesis GO:0000281
A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
1 Q8K298 (/ISO)
Cytokinesis GO:0000910
The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells.
1 Q9V4P1 (/IMP)
Actomyosin contractile ring assembly GO:0000915
The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis.
1 Q9V4P1 (/IMP)
Septin ring assembly GO:0000921
The aggregation, arrangement and bonding together of septins and associated proteins to form an organized structure resembling a ring at the cell cortex.
1 Q9NQW6 (/TAS)
Hematopoietic progenitor cell differentiation GO:0002244
The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells.
1 Q8K298 (/IGI)
Plasma membrane organization GO:0007009
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane.
1 Q9V4P1 (/IMP)
Regulation of exit from mitosis GO:0007096
Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity.
1 Q9NQW6 (/TAS)
Male meiosis cytokinesis GO:0007112
A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells.
1 Q9V4P1 (/IMP)
Pole cell formation GO:0007279
Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells.
1 Q9V4P1 (/IMP)
Cellularization GO:0007349
The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development.
1 Q9V4P1 (/IMP)
Sensory organ development GO:0007423
The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure.
1 Q9V4P1 (/IMP)
Embryo development ending in birth or egg hatching GO:0009792
The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
1 Q9XTT4 (/IMP)
First cell cycle pseudocleavage GO:0030590
A process that occurs during the first cell cycle in an embryo, in which anterior cortical contractions culminate in a single partial constriction of the embryo called the pseudocleavage furrow. An example of this process is found in nematode worms.
1 Q9XTT4 (/IMP)
Male germline ring canal formation GO:0030726
Formation of the intercellular bridges that connect the germ-line cells of a male cyst.
1 Q9V4P1 (/IMP)
Cortical cytoskeleton organization GO:0030865
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.
1 Q9XTT4 (/IMP)
Maintenance of actomyosin contractile ring localization GO:0032189
Any process in which an actomyosin contractile ring is maintained in a location and prevented from moving elsewhere.
1 Q9V4P1 (/IMP)
Regulation of cytokinesis GO:0032465
Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells.
1 Q9V4P1 (/IMP)
Collagen and cuticulin-based cuticle development GO:0040002
Synthesis and deposition of a collagen and cuticulin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Caenorhabditis elegans.
1 Q9XTT4 (/IMP)
Locomotion GO:0040011
Self-propelled movement of a cell or organism from one location to another.
1 Q9XTT4 (/IMP)
Hermaphrodite genitalia development GO:0040035
The process whose specific outcome is the progression of the hermaphrodite genitalia over time, from formation to the mature structures.
1 Q9XTT4 (/IMP)
Polar body extrusion after meiotic divisions GO:0040038
The cell cycle process in which two small cells are generated, as byproducts destined to degenerate, as a result of the first and second meiotic divisions of a primary oocyte during its development to a mature ovum. One polar body is formed in the first division of meiosis and the other in the second division; at each division, the cytoplasm divides unequally, so that the polar body is of much smaller size than the developing oocyte. At the second division in which a polar body is formed, the polar body and the developing oocyte each contain a haploid set of chromosomes.
1 Q9XTT4 (/IMP)
Intercellular bridge organization GO:0043063
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the intracellular bridge. An intracellular bridge is a direct link between the cytoplasms of sister cells that allows cells to communicate with one another.
1 Q9V4P1 (/IMP)
Sensory organ precursor cell division GO:0045035
The series of four asymmetric divisions undergone by the sensory organ precursor cells to generate cells that have distinct cell fates. For example, in the external sensory organ, the precursor cells give rise to one multidendritic neuron and four additional cells (the socket, shaft, sheath cells and the external sense neuron).
1 Q9V4P1 (/IMP)
Nematode male tail tip morphogenesis GO:0045138
The process in which the anatomical structure of the adult male tail tip is generated and organized. In some species of rhabitid nematodes, the male tail tip undergoes a morphological change such that the most posterior hypodermal cells in the tail (hyp8-11 in C. elegans) fuse and retract anteriorly, changing the shape of the tail from a pointed, tapered cone, or spike, to a rounded, blunt dome.
1 Q9XTT4 (/IMP)
Actin filament bundle assembly GO:0051017
The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.
1 Q9XTT4 (/IDA)
Positive regulation of NFAT protein import into nucleus GO:0051533
Any process that activates or increases the frequency, rate or extent of the movement of an NFAT protein from the cytoplasm to the nucleus.
1 Q9V4P1 (/IMP)
Glomerular visceral epithelial cell migration GO:0090521
The orderly movement of a podocyte from one site to another, often during the development of a multicellular organism or multicellular structure. A podocyte is a specialized kidney epithelial cell.
1 Q9NQW6 (/IMP)
Glomerular visceral epithelial cell migration GO:0090521
The orderly movement of a podocyte from one site to another, often during the development of a multicellular organism or multicellular structure. A podocyte is a specialized kidney epithelial cell.
1 Q8K298 (/ISO)
Glomerular visceral epithelial cell migration GO:0090521
The orderly movement of a podocyte from one site to another, often during the development of a multicellular organism or multicellular structure. A podocyte is a specialized kidney epithelial cell.
1 Q8K298 (/ISS)
Positive regulation of bleb assembly GO:1904172
Any process that activates or increases the frequency, rate or extent of bleb assembly.
1 Q9NQW6 (/IMP)

There are 20 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q9V4P1 (/IDA) Q9XTT4 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 A0A024RA49 (/IDA) Q9NQW6 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q9V4P1 (/IDA) Q9XTT4 (/IDA)
Actomyosin contractile ring GO:0005826
A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells. In animal cells, the contractile ring is located inside the plasma membrane at the location of the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms beneath the plasma membrane at the mother-bud neck before mitosis.
2 Q9NQW6 (/IDA) Q9V4P1 (/IDA)
Bleb GO:0032059
A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses.
2 Q801E2 (/ISS) Q8K298 (/ISS)
Cleavage furrow GO:0032154
The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.
2 Q9V4P1 (/IDA) Q9XTT4 (/IDA)
Cell cortex region GO:0099738
The complete extent of cell cortex that underlies some some region of the plasma membrane
2 Q801E2 (/ISS) Q8K298 (/ISS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q8K298 (/ISO)
Actomyosin contractile ring GO:0005826
A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells. In animal cells, the contractile ring is located inside the plasma membrane at the location of the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms beneath the plasma membrane at the mother-bud neck before mitosis.
1 Q8K298 (/ISO)
Cell cortex GO:0005938
The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.
1 Q9XTT4 (/IDA)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
1 Q9NQW6 (/IDA)
Actin cytoskeleton GO:0015629
The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.
1 Q8K298 (/ISO)
Growth cone GO:0030426
The migrating motile tip of a growing nerve cell axon or dendrite.
1 Q9XTT4 (/IDA)
Midbody GO:0030496
A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
1 Q9XTT4 (/IDA)
Cell leading edge GO:0031252
The area of a motile cell closest to the direction of movement.
1 Q9XTT4 (/IDA)
Bleb GO:0032059
A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses.
1 Q9NQW6 (/IDA)
Male germline ring canal GO:0035323
An intercellular bridge that connects the germline cells of a male cyst.
1 Q9V4P1 (/IDA)
Germline ring canal GO:0045172
Germline specific intercellular bridge. During cyst formation in insects, ring canals interconnect the cells of the cyst, facilitating the passage of cytoplasmic components between cells.
1 Q9V4P1 (/IDA)
Contractile ring GO:0070938
A cytoskeletal structure composed of filamentous protein that forms beneath the membrane of many cells or organelles, in the plane of cell or organelle division. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells or organelles.
1 Q9V4P1 (/IDA)
Cell cortex region GO:0099738
The complete extent of cell cortex that underlies some some region of the plasma membrane
1 Q9NQW6 (/IDA)
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