CATH Superfamily 2.30.29.30

FunFam 22481: Insulin receptor substrate 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 33 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

GO Term	Annotations	Evidence
Insulin receptor binding GO:0005158 Interacting selectively and non-covalently with the insulin receptor.	11	B3MPN6 (/ISS) B3N946 (/ISS) B4HWI2 (/ISS) B4NZ70 (/ISS) P35569 (/ISS) P35570 (/ISS) P84770 (/ISS) Q28224 (/ISS) Q6P4Y6 (/ISS) Q9DF49 (/ISS) (1 more)
Insulin-like growth factor receptor binding GO:0005159 Interacting selectively and non-covalently with the insulin-like growth factor receptor.	11	B3MPN6 (/ISS) B3N946 (/ISS) B4HWI2 (/ISS) B4NZ70 (/ISS) P35569 (/ISS) P35570 (/ISS) P84770 (/ISS) Q28224 (/ISS) Q6P4Y6 (/ISS) Q9DF49 (/ISS) (1 more)
Protein binding GO:0005515 Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).	9	F1MAL5 (/IPI) O14654 (/IPI) P35568 (/IPI) P35569 (/IPI) P35570 (/IPI) P81122 (/IPI) Q9XTN2 (/IPI) Q9Y4H2 (/IPI) Q9Z0Y7 (/IPI)
SH2 domain binding GO:0042169 Interacting selectively and non-covalently with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class.	7	P35568 (/ISS) P35569 (/ISS) P84770 (/ISS) Q28224 (/ISS) Q6P4Y6 (/ISS) Q9DF49 (/ISS) Q9XTN2 (/ISS)
Phosphatidylinositol 3-kinase binding GO:0043548 Interacting selectively and non-covalently with a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.	6	P35568 (/ISS) P35569 (/ISS) P84770 (/ISS) Q28224 (/ISS) Q6P4Y6 (/ISS) Q9XTN2 (/ISS)
Signal transducer activity GO:0004871 Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.	3	O14654 (/TAS) P35568 (/TAS) Q9Y4H2 (/TAS)
Phosphatidylinositol 3-kinase binding GO:0043548 Interacting selectively and non-covalently with a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.	3	P35569 (/IDA) P35570 (/IDA) P81122 (/IDA)
Phosphatidylinositol 3-kinase binding GO:0043548 Interacting selectively and non-covalently with a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.	3	F1MAL5 (/IPI) P35568 (/IPI) P35570 (/IPI)
Ras guanyl-nucleotide exchange factor activity GO:0005088 Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.	2	P35568 (/TAS) Q9Y4H2 (/TAS)
Insulin receptor binding GO:0005158 Interacting selectively and non-covalently with the insulin receptor.	2	F1MAL5 (/IMP) P35570 (/IMP)
Insulin receptor binding GO:0005158 Interacting selectively and non-covalently with the insulin receptor.	2	P35568 (/IPI) Q9XTN2 (/IPI)
Insulin-like growth factor receptor binding GO:0005159 Interacting selectively and non-covalently with the insulin-like growth factor receptor.	2	P35568 (/IPI) P35570 (/IPI)
1-phosphatidylinositol-3-kinase activity GO:0016303 Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+).	2	P35568 (/TAS) Q9Y4H2 (/TAS)
Protein kinase binding GO:0019901 Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.	2	P35569 (/IDA) P81122 (/IDA)
Protein domain specific binding GO:0019904 Interacting selectively and non-covalently with a specific domain of a protein.	2	F1MAL5 (/IPI) P35570 (/IPI)
Phosphatidylinositol 3-kinase binding GO:0043548 Interacting selectively and non-covalently with a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.	2	F1MAL5 (/IMP) P35570 (/IMP)
Phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H(+).	2	P35568 (/TAS) Q9Y4H2 (/TAS)
Phosphotyrosine binding GO:0001784 Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein.	1	P35568 (/IPI)
Phosphotyrosine binding GO:0001784 Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein.	1	P35569 (/ISO)
Transmembrane receptor protein tyrosine kinase adaptor activity GO:0005068 The binding activity of a molecule that brings together a transmembrane receptor protein tyrosine kinase and one or more other molecules, permitting them to function in a coordinated way.	1	P35570 (/IMP)
Transmembrane receptor protein tyrosine kinase adaptor activity GO:0005068 The binding activity of a molecule that brings together a transmembrane receptor protein tyrosine kinase and one or more other molecules, permitting them to function in a coordinated way.	1	P35568 (/ISS)
Transmembrane receptor protein tyrosine kinase adaptor activity GO:0005068 The binding activity of a molecule that brings together a transmembrane receptor protein tyrosine kinase and one or more other molecules, permitting them to function in a coordinated way.	1	P35568 (/TAS)
SH3/SH2 adaptor activity GO:0005070 Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68).	1	O14654 (/TAS)
Protein kinase C binding GO:0005080 Interacting selectively and non-covalently with protein kinase C.	1	P35570 (/IPI)
Protein kinase C binding GO:0005080 Interacting selectively and non-covalently with protein kinase C.	1	P35568 (/ISS)
Insulin receptor binding GO:0005158 Interacting selectively and non-covalently with the insulin receptor.	1	P35569 (/ISO)
Insulin-like growth factor receptor binding GO:0005159 Interacting selectively and non-covalently with the insulin-like growth factor receptor.	1	Q9XTN2 (/IGI)
Insulin-like growth factor receptor binding GO:0005159 Interacting selectively and non-covalently with the insulin-like growth factor receptor.	1	P35569 (/ISO)
Protein kinase binding GO:0019901 Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.	1	P35570 (/IPI)
Protein phosphatase binding GO:0019903 Interacting selectively and non-covalently with any protein phosphatase.	1	F1MAL5 (/IPI)
SH2 domain binding GO:0042169 Interacting selectively and non-covalently with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class.	1	P35570 (/IPI)
Phosphatidylinositol 3-kinase binding GO:0043548 Interacting selectively and non-covalently with a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.	1	P35569 (/ISO)
14-3-3 protein binding GO:0071889 Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxyl terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins.	1	F1MAL5 (/IDA)

There are 125 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

GO Term	Annotations	Evidence
Insulin-like growth factor receptor signaling pathway GO:0048009 The series of molecular signals generated as a consequence of the insulin-like growth factor receptor binding to one of its physiological ligands.	11	B3MPN6 (/ISS) B3N946 (/ISS) B4HWI2 (/ISS) B4NZ70 (/ISS) P35569 (/ISS) P35570 (/ISS) P84770 (/ISS) Q28224 (/ISS) Q6P4Y6 (/ISS) Q9DF49 (/ISS) (1 more)
Insulin receptor signaling pathway GO:0008286 The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.	5	B3MPN6 (/ISS) B3N946 (/ISS) B4HWI2 (/ISS) B4NZ70 (/ISS) Q9Y4H2 (/ISS)
Vitellogenesis GO:0007296 The production of yolk. Yolk is a mixture of materials used for embryonic nutrition.	4	B3MPN6 (/ISS) B3N946 (/ISS) B4HWI2 (/ISS) B4NZ70 (/ISS)
Multicellular organism aging GO:0010259 An aging process that has as participant a whole multicellular organism. Multicellular organism aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Multicellular organisms aging includes processes like cellular senescence and organ senescence, but is more inclusive. May precede death (GO:0016265) of an organism and may succeed developmental maturation (GO:0021700).	4	B3MPN6 (/ISS) B3N946 (/ISS) B4HWI2 (/ISS) B4NZ70 (/ISS)
Phosphatidylinositol-mediated signaling GO:0048015 A series of molecular signals in which a cell uses a phosphatidylinositol-mediated signaling to convert a signal into a response. Phosphatidylinositols include phosphatidylinositol (PtdIns) and its phosphorylated derivatives.	4	P35568 (/TAS) P35569 (/TAS) P81122 (/TAS) Q9Y4H2 (/TAS)
Signal transduction GO:0007165 The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.	3	O14654 (/TAS) P35568 (/TAS) Q9Y4H2 (/TAS)
Insulin receptor signaling pathway GO:0008286 The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.	3	P35568 (/IDA) P35570 (/IDA) Q9DF49 (/IDA)
Insulin receptor signaling pathway GO:0008286 The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.	3	F1MAL5 (/IMP) P35568 (/IMP) P81122 (/IMP)
Cellular response to insulin stimulus GO:0032869 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.	3	F1MAL5 (/IDA) P35569 (/IDA) P81122 (/IDA)
MAPK cascade GO:0000165 An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.	2	P35568 (/TAS) Q9Y4H2 (/TAS)
Positive regulation of mesenchymal cell proliferation GO:0002053 The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells.	2	P35569 (/IGI) P81122 (/IGI)
Positive regulation of cell proliferation GO:0008284 Any process that activates or increases the rate or extent of cell proliferation.	2	P35568 (/NAS) Q9Y4H2 (/NAS)
Insulin receptor signaling pathway GO:0008286 The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.	2	P35568 (/IPI) Q9XTN2 (/IPI)
Positive regulation of glucose metabolic process GO:0010907 Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.	2	P35568 (/IMP) Q9Y4H2 (/IMP)
Positive regulation of glucose metabolic process GO:0010907 Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.	2	P35569 (/ISO) P81122 (/ISO)
Regulation of phosphatidylinositol 3-kinase signaling GO:0014066 Any process that modulates the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade.	2	P35568 (/TAS) Q9Y4H2 (/TAS)
Positive regulation of cell migration GO:0030335 Any process that activates or increases the frequency, rate or extent of cell migration.	2	P35569 (/IGI) P81122 (/IGI)
Mammary gland development GO:0030879 The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages.	2	P35569 (/IGI) P81122 (/IGI)
Positive regulation of fatty acid beta-oxidation GO:0032000 Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation.	2	P35568 (/IMP) Q9Y4H2 (/IMP)
Positive regulation of fatty acid beta-oxidation GO:0032000 Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation.	2	P35569 (/ISO) P81122 (/ISO)
Cellular response to insulin stimulus GO:0032869 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.	2	P35568 (/IMP) Q9Y4H2 (/IMP)
Cellular response to insulin stimulus GO:0032869 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.	2	P35569 (/ISO) P81122 (/ISO)
Positive regulation of glycogen biosynthetic process GO:0045725 Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.	2	P35568 (/IMP) Q9Y4H2 (/IMP)
Positive regulation of glycogen biosynthetic process GO:0045725 Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.	2	P35569 (/ISO) P81122 (/ISO)
Positive regulation of glycogen biosynthetic process GO:0045725 Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen.	2	P35568 (/NAS) Q9Y4H2 (/NAS)
Positive regulation of glucose import GO:0046326 Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.	2	P35568 (/IMP) Q9Y4H2 (/IMP)
Positive regulation of glucose import GO:0046326 Any process that activates or increases the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell or organelle.	2	P35569 (/ISO) P81122 (/ISO)
JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 The process in which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of physiological ligands to the growth hormone receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes.	2	F1MAL5 (/TAS) P35570 (/TAS)
Cell morphogenesis GO:0000902 The developmental process in which the size or shape of a cell is generated and organized.	1	Q9XTN2 (/IMP)
Response to hypoxia GO:0001666 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.	1	F1QHL0 (/IMP)
Negative regulation of B cell apoptotic process GO:0002903 Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptotic process.	1	P81122 (/IMP)
Negative regulation of B cell apoptotic process GO:0002903 Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptotic process.	1	Q9Y4H2 (/ISS)
Glucose metabolic process GO:0006006 The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides.	1	Q9Y4H2 (/TAS)
Lipid metabolic process GO:0006629 The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids.	1	Q9XTN2 (/IMP)
Primary spermatocyte growth GO:0007285 The phase of growth and gene expression that male germ cells undergo as they enter the spermatocyte stage. The cells grow in volume and transcribe most of the gene products needed for the morphological events that follow meiosis.	1	Q9XTN2 (/IMP)
Growth of a germarium-derived egg chamber GO:0007295 Growth of the egg chamber between the time it leaves the germarium and the onset of vitellogenesis. During this time both nurse cells and the oocyte undergo developmental changes including nuclear organization and cytoplasmic growth. An example of this is found in Drosophila melanogaster.	1	Q9XTN2 (/IMP)
Vitellogenesis GO:0007296 The production of yolk. Yolk is a mixture of materials used for embryonic nutrition.	1	Q9XTN2 (/IMP)
Axon guidance GO:0007411 The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.	1	Q9Y4H2 (/TAS)
Brain development GO:0007420 The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).	1	P81122 (/IMP)
Aging GO:0007568 A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).	1	P35570 (/IEP)
Aging GO:0007568 A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).	1	Q9XTN2 (/IMP)
Cell proliferation GO:0008283 The multiplication or reproduction of cells, resulting in the expansion of a cell population.	1	P81122 (/IMP)
Positive regulation of cell proliferation GO:0008284 Any process that activates or increases the rate or extent of cell proliferation.	1	P81122 (/IGI)
Insulin receptor signaling pathway GO:0008286 The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.	1	Q9XTN2 (/IGI)
Insulin receptor signaling pathway GO:0008286 The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.	1	P35569 (/ISO)
Insulin receptor signaling pathway GO:0008286 The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.	1	Q9XTN2 (/NAS)
Insulin receptor signaling pathway GO:0008286 The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.	1	Q9XTN2 (/TAS)
Determination of adult lifespan GO:0008340 The control of viability and duration in the adult phase of the life-cycle.	1	Q9XTN2 (/IMP)
Determination of adult lifespan GO:0008340 The control of viability and duration in the adult phase of the life-cycle.	1	Q9XTN2 (/TAS)
Olfactory learning GO:0008355 Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue.	1	Q9XTN2 (/IMP)
Regulation of cell size GO:0008361 Any process that modulates the size of a cell.	1	Q9XTN2 (/NAS)
Regulation of cell size GO:0008361 Any process that modulates the size of a cell.	1	Q9XTN2 (/TAS)
Response to glucose GO:0009749 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.	1	P81122 (/IDA)
Response to glucose GO:0009749 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.	1	Q9Y4H2 (/ISS)
Multicellular organism aging GO:0010259 An aging process that has as participant a whole multicellular organism. Multicellular organism aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Multicellular organisms aging includes processes like cellular senescence and organ senescence, but is more inclusive. May precede death (GO:0016265) of an organism and may succeed developmental maturation (GO:0021700).	1	Q9XTN2 (/IMP)
Regulation of gene expression GO:0010468 Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.	1	P35569 (/IMP)
Negative regulation of plasma membrane long-chain fatty acid transport GO:0010748 Any process that decreases the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane.	1	Q9Y4H2 (/IMP)
Negative regulation of plasma membrane long-chain fatty acid transport GO:0010748 Any process that decreases the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane.	1	P81122 (/ISO)
Regulation of glucose metabolic process GO:0010906 Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.	1	Q9XTN2 (/IMP)
Phosphatidylinositol 3-kinase signaling GO:0014065 A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions.	1	P35568 (/IDA)
Phosphatidylinositol 3-kinase signaling GO:0014065 A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions.	1	P35569 (/ISO)
Response to activity GO:0014823 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus.	1	P35570 (/IEP)
Lipid catabolic process GO:0016042 The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.	1	P35569 (/IMP)
Regulation of lipid metabolic process GO:0019216 Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.	1	Q9Y4H2 (/TAS)
Positive regulation of cell growth GO:0030307 Any process that activates or increases the frequency, rate, extent or direction of cell growth.	1	Q9XTN2 (/NAS)
Positive regulation of B cell proliferation GO:0030890 Any process that activates or increases the rate or extent of B cell proliferation.	1	P81122 (/IDA)
Positive regulation of B cell proliferation GO:0030890 Any process that activates or increases the rate or extent of B cell proliferation.	1	Q9Y4H2 (/ISS)
Response to caffeine GO:0031000 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them.	1	P35570 (/IDA)
Response to caffeine GO:0031000 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them.	1	P35570 (/IEP)
Positive regulation of insulin secretion GO:0032024 Any process that activates or increases the frequency, rate or extent of the regulated release of insulin.	1	P81122 (/IMP)
Positive regulation of insulin secretion GO:0032024 Any process that activates or increases the frequency, rate or extent of the regulated release of insulin.	1	Q9Y4H2 (/ISS)
Response to insulin GO:0032868 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.	1	P35568 (/IDA)
Response to insulin GO:0032868 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.	1	P35569 (/ISO)
Regulation of activin receptor signaling pathway GO:0032925 Any process that modulates the frequency, rate or extent of the activity of any activin receptor signaling pathway.	1	Q9XTN2 (/IMP)
Negative regulation of kinase activity GO:0033673 Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.	1	P81122 (/IMP)
Negative regulation of kinase activity GO:0033673 Any process that stops, prevents, or reduces the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.	1	Q9Y4H2 (/ISS)
Response to anoxia GO:0034059 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating a decline in oxygen levels to trace amounts, <0.1%.	1	Q9XTN2 (/IDA)
Protein localization to nucleus GO:0034504 A process in which a protein is transported to, or maintained in, a location within the nucleus.	1	P35569 (/IDA)
Protein localization to nucleus GO:0034504 A process in which a protein is transported to, or maintained in, a location within the nucleus.	1	P35569 (/IMP)
Regulation of tube length, open tracheal system GO:0035159 Ensuring that a tube in an open tracheal system is of the correct length.	1	Q9XTN2 (/IMP)
Multicellular organism growth GO:0035264 The increase in size or mass of an entire multicellular organism, as opposed to cell growth.	1	Q9XTN2 (/IMP)
Regulation of multicellular organism growth GO:0040014 Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.	1	Q9XTN2 (/TAS)
Positive regulation of multicellular organism growth GO:0040018 Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.	1	Q9XTN2 (/IMP)
Positive regulation of multicellular organism growth GO:0040018 Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.	1	Q9XTN2 (/TAS)
Positive regulation of phosphorylation GO:0042327 Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule.	1	P35570 (/IDA)
Glucose homeostasis GO:0042593 Any process involved in the maintenance of an internal steady state of glucose within an organism or cell.	1	P35568 (/TAS)
Response to starvation GO:0042594 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.	1	Q9XTN2 (/IMP)
Response to starvation GO:0042594 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment.	1	Q9XTN2 (/TAS)
Response to peptide hormone GO:0043434 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.	1	P35570 (/IDA)
Response to peptide hormone GO:0043434 Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.	1	P35568 (/ISS)
Protein kinase B signaling GO:0043491 A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound.	1	P35569 (/IGI)
Positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase activity.	1	P35570 (/IDA)
Positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase activity.	1	P35569 (/IMP)
Positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase activity.	1	P35568 (/ISS)
Cellular metabolic process GO:0044237 The chemical reactions and pathways by which individual cells transform chemical substances.	1	Q9XTN2 (/TAS)
Positive regulation of cell size GO:0045793 Any process that increases cell size.	1	Q9XTN2 (/NAS)
Positive regulation of cell size GO:0045793 Any process that increases cell size.	1	Q9XTN2 (/TAS)
Regulation of organ growth GO:0046620 Any process that modulates the frequency, rate or extent of growth of an organ of an organism.	1	Q9XTN2 (/IMP)
Regulation of organ growth GO:0046620 Any process that modulates the frequency, rate or extent of growth of an organ of an organism.	1	Q9XTN2 (/NAS)
Positive regulation of organ growth GO:0046622 Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism.	1	Q9XTN2 (/NAS)
Positive regulation of organ growth GO:0046622 Any process that activates or increases the frequency, rate or extent of growth of an organ of an organism.	1	Q9XTN2 (/TAS)
Negative regulation of insulin receptor signaling pathway GO:0046627 Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.	1	P35570 (/IMP)
Negative regulation of insulin receptor signaling pathway GO:0046627 Any process that stops, prevents, or reduces the frequency, rate or extent of insulin receptor signaling.	1	P35568 (/ISS)
Positive regulation of insulin receptor signaling pathway GO:0046628 Any process that increases the frequency, rate or extent of insulin receptor signaling.	1	P35570 (/IMP)
Positive regulation of insulin receptor signaling pathway GO:0046628 Any process that increases the frequency, rate or extent of insulin receptor signaling.	1	P35568 (/ISS)
Negative regulation of insulin secretion GO:0046676 Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.	1	P35568 (/IDA)
Negative regulation of insulin secretion GO:0046676 Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.	1	P35570 (/IMP)
Negative regulation of insulin secretion GO:0046676 Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.	1	P35569 (/ISO)
Insulin-like growth factor receptor signaling pathway GO:0048009 The series of molecular signals generated as a consequence of the insulin-like growth factor receptor binding to one of its physiological ligands.	1	P35568 (/IPI)
Insulin-like growth factor receptor signaling pathway GO:0048009 The series of molecular signals generated as a consequence of the insulin-like growth factor receptor binding to one of its physiological ligands.	1	P35569 (/ISO)
Male germ-line stem cell asymmetric division GO:0048133 The self-renewing division of a germline stem cell in the male gonad, to produce a daughter stem cell and a daughter germ cell, which will divide to form the male gametes.	1	Q9XTN2 (/IMP)
Positive regulation of immune response GO:0050778 Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.	1	Q9XTN2 (/IMP)
Protein heterooligomerization GO:0051291 The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.	1	P35570 (/IDA)
Lipid homeostasis GO:0055088 Any process involved in the maintenance of an internal steady state of lipid within an organism or cell.	1	Q9Y4H2 (/TAS)
Germ-line stem-cell niche homeostasis GO:0060250 A homeostatic process involved in the maintenance of an internal steady state within the germ-line stem-cell niche. This includes control of cellular proliferation and death and control of metabolic function that allows the niche to continue to function. A gem-line stem-cell niche is an anatomical structure that regulates how germ-line stem-cells are used and saves them from depletion.	1	Q9XTN2 (/IMP)
Long-term synaptic potentiation GO:0060291 A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse.	1	Q9XTN2 (/IMP)
Positive regulation of glucagon secretion GO:0070094 Any process that activates or increases the frequency, rate or extent of the regulated release of glucagon.	1	P35570 (/IMP)
Cellular response to glucose stimulus GO:0071333 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.	1	F1MAL5 (/IEP)
Cellular response to radiation GO:0071478 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.	1	P35570 (/IEP)
Negative regulation of somatostatin secretion GO:0090275 Any process that decreases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas.	1	P35570 (/IMP)
Cellular response to peptide GO:1901653 Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide stimulus.	1	F1MAL5 (/IEP)
Cellular response to angiotensin GO:1904385 \Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen.\	1	P35570 (/IDA)
Cellular response to brain-derived neurotrophic factor stimulus GO:1990416 A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brain-derived neurotrophic factor stimulus.	1	P35570 (/IEP)
Positive regulation of glucose import in response to insulin stimulus GO:2001275 Any process that activates or increases the frequency, rate or extent of glucose import in response to insulin stimulus.	1	P35568 (/IDA)
Positive regulation of glucose import in response to insulin stimulus GO:2001275 Any process that activates or increases the frequency, rate or extent of glucose import in response to insulin stimulus.	1	P35569 (/ISO)

There are 17 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

GO Term	Annotations	Evidence
Nucleus GO:0005634 A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.	11	B3MPN6 (/ISS) B3N946 (/ISS) B4HWI2 (/ISS) B4NZ70 (/ISS) P35568 (/ISS) P35570 (/ISS) P84770 (/ISS) Q28224 (/ISS) Q6P4Y6 (/ISS) Q9DF49 (/ISS) (1 more)
Cytoplasm GO:0005737 All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.	11	B3MPN6 (/ISS) B3N946 (/ISS) B4HWI2 (/ISS) B4NZ70 (/ISS) P35568 (/ISS) P35570 (/ISS) P84770 (/ISS) Q28224 (/ISS) Q6P4Y6 (/ISS) Q9DF49 (/ISS) (1 more)
Intracellular membrane-bounded organelle GO:0043231 Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.	11	B3MPN6 (/ISS) B3N946 (/ISS) B4HWI2 (/ISS) B4NZ70 (/ISS) P35568 (/ISS) P35570 (/ISS) P84770 (/ISS) Q28224 (/ISS) Q6P4Y6 (/ISS) Q9DF49 (/ISS) (1 more)
Cytosol GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.	6	F1MAL5 (/TAS) P35568 (/TAS) P35569 (/TAS) P35570 (/TAS) P81122 (/TAS) Q9Y4H2 (/TAS)
Plasma membrane GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.	3	P35569 (/IDA) P35570 (/IDA) P81122 (/IDA)
Plasma membrane GO:0005886 The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.	3	O14654 (/TAS) P35568 (/TAS) Q9Y4H2 (/TAS)
Cytosol GO:0005829 The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.	2	P35570 (/IDA) P81122 (/IDA)
Nucleus GO:0005634 A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.	1	P35569 (/IDA)
Cytoplasm GO:0005737 All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.	1	P35569 (/IDA)
Cytoplasm GO:0005737 All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.	1	P35568 (/TAS)
Insulin receptor complex GO:0005899 A disulfide-bonded, heterotetrameric receptor complex. The alpha chains are entirely extracellular, while each beta chain has one transmembrane domain. The ligand binds to the alpha subunit extracellular domain and the kinase is associated with the beta subunit intracellular domain.	1	P35570 (/IMP)
Insulin receptor complex GO:0005899 A disulfide-bonded, heterotetrameric receptor complex. The alpha chains are entirely extracellular, while each beta chain has one transmembrane domain. The ligand binds to the alpha subunit extracellular domain and the kinase is associated with the beta subunit intracellular domain.	1	P35568 (/ISS)
Caveola GO:0005901 A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.	1	P35568 (/IDA)
Caveola GO:0005901 A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.	1	P35569 (/ISO)
Ciliary basal body GO:0036064 A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.	1	P35569 (/IDA)
Intracellular membrane-bounded organelle GO:0043231 Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.	1	P35570 (/IDA)
Protein complex GO:0043234 A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical.	1	P81122 (/IDA)

CATH Superfamily 2.30.29.30

Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Functional Families

FunFam 22481: Insulin receptor substrate 1

There are 33 GO terms relating to "molecular function"

There are 125 GO terms relating to "biological process"

There are 17 GO terms relating to "cellular component"