The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 22102: Sprouty-related, EVH1 domain-containing protein 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 Q7Z698 (/IPI) Q7Z699 (/IPI) Q924S7 (/IPI) Q924S8 (/IPI)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
4 Q7Z698 (/IPI) Q7Z699 (/IPI) Q924S7 (/IPI) Q924S8 (/IPI)
Stem cell factor receptor binding GO:0005173
Interacting selectively and non-covalently with the stem cell factor receptor (SCFR), a type III transmembrane kinase receptor.
2 Q924S7 (/IPI) Q924S8 (/IPI)
Stem cell factor receptor binding GO:0005173
Interacting selectively and non-covalently with the stem cell factor receptor (SCFR), a type III transmembrane kinase receptor.
2 Q7Z698 (/ISS) Q7Z699 (/ISS)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
2 Q924S7 (/ISO) Q924S8 (/ISO)
Phosphatase binding GO:0019902
Interacting selectively and non-covalently with any phosphatase.
2 Q66JG9 (/ISS) Q924S8 (/ISS)
Protein serine/threonine kinase inhibitor activity GO:0030291
Stops, prevents or reduces the activity of a protein serine/threonine kinase.
2 Q924S7 (/IDA) Q924S8 (/IDA)
Protein serine/threonine kinase inhibitor activity GO:0030291
Stops, prevents or reduces the activity of a protein serine/threonine kinase.
2 Q7Z698 (/ISS) Q7Z699 (/ISS)
Phosphatase binding GO:0019902
Interacting selectively and non-covalently with any phosphatase.
1 Q7Z699 (/IDA)
Phosphatase binding GO:0019902
Interacting selectively and non-covalently with any phosphatase.
1 Q924S8 (/ISO)

There are 16 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Inactivation of MAPK activity GO:0000188
Any process that terminates the activity of the active enzyme MAP kinase.
2 Q924S7 (/IMP) Q924S8 (/IMP)
Inactivation of MAPK activity GO:0000188
Any process that terminates the activity of the active enzyme MAP kinase.
2 Q7Z698 (/ISS) Q7Z699 (/ISS)
Fibroblast growth factor receptor signaling pathway GO:0008543
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
2 Q7Z698 (/TAS) Q7Z699 (/TAS)
Negative regulation of peptidyl-threonine phosphorylation GO:0010801
Any process that decreases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
2 Q924S7 (/IDA) Q924S8 (/IDA)
Negative regulation of peptidyl-threonine phosphorylation GO:0010801
Any process that decreases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
2 Q7Z698 (/IMP) Q7Z699 (/IMP)
Negative regulation of peptidyl-threonine phosphorylation GO:0010801
Any process that decreases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
2 Q924S7 (/ISO) Q924S8 (/ISO)
Negative regulation of phosphatase activity GO:0010923
Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
2 Q66JG9 (/ISS) Q924S8 (/ISS)
Positive regulation of DNA damage response, signal transduction by p53 class mediator GO:0043517
Any process that activates, maintains or increases the rate of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.
2 Q924S7 (/IDA) Q924S8 (/IDA)
Positive regulation of DNA damage response, signal transduction by p53 class mediator GO:0043517
Any process that activates, maintains or increases the rate of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.
2 Q7Z698 (/ISS) Q7Z699 (/ISS)
Regulation of protein deacetylation GO:0090311
Any process that modulates the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic
2 Q924S7 (/IDA) Q924S8 (/IDA)
Regulation of protein deacetylation GO:0090311
Any process that modulates the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic
2 Q7Z698 (/ISS) Q7Z699 (/ISS)
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
1 Q7Z699 (/TAS)
Negative regulation of phosphatase activity GO:0010923
Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
1 Q7Z699 (/IDA)
Negative regulation of phosphatase activity GO:0010923
Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.
1 Q924S8 (/ISO)
Regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947
Any process that modulates the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.
1 F1R8L9 (/IMP)
Blood vessel morphogenesis GO:0048514
The process in which the anatomical structures of blood vessels are generated and organized. The blood vessel is the vasculature carrying blood.
1 F1R8L9 (/IMP)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 H0YMN8 (/IDA) Q7Z699 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q7Z698 (/TAS) Q7Z699 (/TAS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q924S8 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q924S7 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q7Z699 (/TAS)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
1 Q924S7 (/IDA)
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