CATH Superfamily 2.30.29.30
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".
FunFam 1943: WASp, isoform C
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 2 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Actin binding GO:0003779
Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments.
|
2 | Q86B74 (/ISS) Q9VAT0 (/ISS) |
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | Q86B74 (/IPI) Q9VAT0 (/IPI) |
There are 23 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Microtubule bundle formation GO:0001578
A process that results in a parallel arrangement of microtubules.
|
2 | Q86B74 (/IDA) Q9VAT0 (/IDA) |
Apical constriction GO:0003383
The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell.
|
2 | Q86B74 (/IMP) Q9VAT0 (/IMP) |
Intracellular protein transport GO:0006886
The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
|
2 | Q86B74 (/IMP) Q9VAT0 (/IMP) |
Membrane budding GO:0006900
The evagination of a membrane, resulting in formation of a vesicle.
|
2 | Q86B74 (/IMP) Q9VAT0 (/IMP) |
Spermatid development GO:0007286
The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.
|
2 | Q86B74 (/IMP) Q9VAT0 (/IMP) |
Axonogenesis GO:0007409
De novo generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells. Refers to the morphogenesis or creation of shape or form of the developing axon.
|
2 | Q86B74 (/IGI) Q9VAT0 (/IGI) |
Axonal fasciculation GO:0007413
The collection of axons into a bundle of rods, known as a fascicle.
|
2 | Q86B74 (/IGI) Q9VAT0 (/IGI) |
Sensory organ development GO:0007423
The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure.
|
2 | Q86B74 (/IMP) Q9VAT0 (/IMP) |
Myoblast fusion GO:0007520
A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
|
2 | Q86B74 (/IGI) Q9VAT0 (/IGI) |
Myoblast fusion GO:0007520
A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
|
2 | Q86B74 (/IMP) Q9VAT0 (/IMP) |
Asymmetric cell division GO:0008356
The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity.
|
2 | Q86B74 (/TAS) Q9VAT0 (/TAS) |
Chaeta morphogenesis GO:0008407
The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell.
|
2 | Q86B74 (/IMP) Q9VAT0 (/IMP) |
Regulation of synaptic growth at neuromuscular junction GO:0008582
Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions.
|
2 | Q86B74 (/IDA) Q9VAT0 (/IDA) |
Epidermal cell differentiation GO:0009913
The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis.
|
2 | Q86B74 (/IMP) Q9VAT0 (/IMP) |
Muscle attachment GO:0016203
The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall).
|
2 | Q86B74 (/IMP) Q9VAT0 (/IMP) |
Regulation of embryonic cell shape GO:0016476
Any process that modulates the surface configuration of an embryonic cell.
|
2 | Q86B74 (/IMP) Q9VAT0 (/IMP) |
Regulation of actin filament polymerization GO:0030833
Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament.
|
2 | Q86B74 (/IMP) Q9VAT0 (/IMP) |
Arp2/3 complex-mediated actin nucleation GO:0034314
The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins.
|
2 | Q86B74 (/IDA) Q9VAT0 (/IDA) |
Cuticle pattern formation GO:0035017
The regionalization process that gives rise to the patterns of cell differentiation in the cuticle.
|
2 | Q86B74 (/IMP) Q9VAT0 (/IMP) |
Cell competition in a multicellular organism GO:0035212
Competitive interactions within multicellular organisms between cell populations that differ in growth rates, leading to the elimination of the slowest-growing cells.
|
2 | Q86B74 (/IMP) Q9VAT0 (/IMP) |
Cell fate commitment GO:0045165
The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.
|
2 | Q86B74 (/TAS) Q9VAT0 (/TAS) |
Negative regulation of synaptic growth at neuromuscular junction GO:0045886
Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic growth at neuromuscular junction.
|
2 | Q86B74 (/IMP) Q9VAT0 (/IMP) |
Clathrin-dependent endocytosis GO:0072583
An endocytosis process that begins when material is taken up into clathrin-coated pits, which then pinch off to form clathrin-coated endocytic vesicles.
|
2 | Q86B74 (/IMP) Q9VAT0 (/IMP) |
There are 5 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
2 | Q86B74 (/IDA) Q9VAT0 (/IDA) |
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | Q86B74 (/IDA) Q9VAT0 (/IDA) |
Microvillus GO:0005902
Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.
|
2 | Q86B74 (/IMP) Q9VAT0 (/IMP) |
Rhabdomere GO:0016028
The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction.
|
2 | Q86B74 (/IMP) Q9VAT0 (/IMP) |
Neuromuscular junction GO:0031594
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.
|
2 | Q86B74 (/IDA) Q9VAT0 (/IDA) |