The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 16516: Protein expanded

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 1 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q07436 (/IPI)

There are 29 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Compound eye morphogenesis GO:0001745
The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.
1 Q07436 (/IGI)
Compound eye morphogenesis GO:0001745
The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.
1 Q07436 (/IMP)
Compound eye photoreceptor cell differentiation GO:0001751
The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell.
1 Q07436 (/IGI)
Compound eye photoreceptor cell differentiation GO:0001751
The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell.
1 Q07436 (/IMP)
Cell cycle arrest GO:0007050
A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M).
1 Q07436 (/IGI)
Regulation of exit from mitosis GO:0007096
Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity.
1 Q07436 (/IMP)
Border follicle cell migration GO:0007298
The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster.
1 Q07436 (/IMP)
Decapentaplegic signaling pathway GO:0008101
A series of molecular signals initiated by the binding of decapentaplegic (dpp) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 Q07436 (/IGI)
Negative regulation of cell proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q07436 (/IGI)
Negative regulation of cell proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q07436 (/IMP)
Regulation of signal transduction GO:0009966
Any process that modulates the frequency, rate or extent of signal transduction.
1 Q07436 (/IGI)
Ovarian follicle cell development GO:0030707
The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster.
1 Q07436 (/IMP)
Endocytic recycling GO:0032456
The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport.
1 Q07436 (/IGI)
Hippo signaling GO:0035329
The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1.
1 Q07436 (/IGI)
Regulation of hippo signaling GO:0035330
Any process that modulates the frequency, rate or extent of hippo signaling.
1 Q07436 (/IMP)
Negative regulation of hippo signaling GO:0035331
Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling.
1 Q07436 (/IGI)
Negative regulation of hippo signaling GO:0035331
Any process that stops, prevents, or reduces the frequency, rate or extent of hippo signaling.
1 Q07436 (/IPI)
Regulation of growth GO:0040008
Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development.
1 Q07436 (/IGI)
Regulation of growth GO:0040008
Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development.
1 Q07436 (/IMP)
Positive regulation of phosphorylation GO:0042327
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule.
1 Q07436 (/IGI)
Regulation of apoptotic process GO:0042981
Any process that modulates the occurrence or rate of cell death by apoptotic process.
1 Q07436 (/IGI)
Negative regulation of imaginal disc growth GO:0045571
Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc growth.
1 Q07436 (/IGI)
Negative regulation of imaginal disc growth GO:0045571
Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc growth.
1 Q07436 (/IMP)
Negative regulation of imaginal disc growth GO:0045571
Any process that stops, prevents, or reduces the frequency, rate or extent of imaginal disc growth.
1 Q07436 (/TAS)
Regulation of cell differentiation GO:0045595
Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features.
1 Q07436 (/IGI)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 Q07436 (/IDA)
Regulation of organ growth GO:0046620
Any process that modulates the frequency, rate or extent of growth of an organ of an organism.
1 Q07436 (/IGI)
Negative regulation of organ growth GO:0046621
Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism.
1 Q07436 (/IGI)
Negative regulation of organ growth GO:0046621
Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organ of an organism.
1 Q07436 (/IMP)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Zonula adherens GO:0005915
A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells.
1 Q07436 (/TAS)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 Q07436 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 Q07436 (/TAS)
Kibra-Ex-Mer complex GO:0036375
An apical protein complex that contains the proteins Kibra, Expanded and Merlin (Mer), or orthologs thereof. In humans, the complex contains KIBRA, FDM6 and NF2.
1 Q07436 (/IDA)
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