The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:
"Laminin
".
FunFam 45129: Laminin subunit alpha-1 isoform 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 7 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | P19137 (/IPI) P25391 (/IPI) |
Structural molecule activity GO:0005198
The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.
|
1 | P24043 (/TAS) |
Extracellular matrix structural constituent GO:0005201
The action of a molecule that contributes to the structural integrity of the extracellular matrix.
|
1 | P19137 (/IDA) |
Extracellular matrix structural constituent GO:0005201
The action of a molecule that contributes to the structural integrity of the extracellular matrix.
|
1 | P25391 (/ISS) |
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxy function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
1 | P25391 (/IPI) |
Protein C-terminus binding GO:0008022
Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxy function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue.
|
1 | P19137 (/ISO) |
Glycosphingolipid binding GO:0043208
Interacting selectively and non-covalently with glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide.
|
1 | P19137 (/IDA) |
There are 24 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Extracellular matrix organization GO:0030198
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
|
4 | P19137 (/TAS) P24043 (/TAS) P25391 (/TAS) Q60675 (/TAS) |
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
|
3 | A0A0G2KI51 (/IMP) G8IHT9 (/IMP) G8IHU0 (/IMP) |
Muscle attachment GO:0016203
The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall).
|
3 | A0A0G2KI51 (/IGI) G8IHT9 (/IGI) G8IHU0 (/IGI) |
Muscle attachment GO:0016203
The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall).
|
3 | A0A0G2KI51 (/IMP) G8IHT9 (/IMP) G8IHU0 (/IMP) |
Myelination in peripheral nervous system GO:0022011
The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier.
|
3 | A0A0G2KI51 (/IGI) G8IHT9 (/IGI) G8IHU0 (/IGI) |
Skeletal muscle organ development GO:0060538
The progression of a skeletal muscle organ over time from its initial formation to its mature state. A skeletal muscle organ includes the skeletal muscle tissue and its associated connective tissue.
|
3 | A0A0G2KI51 (/IMP) G8IHT9 (/IMP) G8IHU0 (/IMP) |
Receptor-mediated endocytosis GO:0006898
An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles.
|
2 | P19137 (/TAS) Q60675 (/TAS) |
Morphogenesis of an epithelial sheet GO:0002011
The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells.
|
1 | P19137 (/IMP) |
Protein phosphorylation GO:0006468
The process of introducing a phosphate group on to a protein.
|
1 | P19137 (/IDA) |
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
|
1 | P19137 (/IDA) |
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
|
1 | P25391 (/ISS) |
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
|
1 | Q60675 (/IGI) |
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
|
1 | P19137 (/TAS) |
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
|
1 | P24043 (/TAS) |
Tissue development GO:0009888
The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure.
|
1 | P19137 (/IMP) |
Schwann cell differentiation GO:0014037
The process in which a relatively unspecialized cell acquires the specialized features of a Schwann cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function.
|
1 | F1M614 (/IEP) |
Extracellular matrix disassembly GO:0022617
A process that results in the breakdown of the extracellular matrix.
|
1 | P19137 (/TAS) |
Neuron projection development GO:0031175
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).
|
1 | P19137 (/IDA) |
Positive regulation of synaptic transmission, cholinergic GO:0032224
Any process that activates, maintains or increases the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine.
|
1 | Q60675 (/IMP) |
Establishment of epithelial cell apical/basal polarity GO:0045198
The specification and formation of the apicobasal polarity of an epithelial cell.
|
1 | P19137 (/IMP) |
Retina development in camera-type eye GO:0060041
The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
|
1 | P19137 (/IMP) |
Epithelial tube branching involved in lung morphogenesis GO:0060441
The process in which a highly ordered sequence of patterning events generates the branched epithelial tubes of the lung, consisting of reiterated combinations of bud outgrowth, elongation, and dichotomous subdivision of terminal units.
|
1 | P19137 (/IMP) |
Branching involved in salivary gland morphogenesis GO:0060445
The process in which the branching structure of the salivary gland is generated and organized.
|
1 | P19137 (/IMP) |
Retinal blood vessel morphogenesis GO:0061304
The process whose specific outcome is the progression of a blood vessel of the retina over time, from its formation to the mature structure.
|
1 | P19137 (/IMP) |
There are 26 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
GO Term | Annotations | Evidence |
---|---|---|
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
4 | P19137 (/TAS) P24043 (/TAS) P25391 (/TAS) Q60675 (/TAS) |
Basement membrane GO:0005604
A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
|
4 | P19137 (/IDA) P24043 (/IDA) P25391 (/IDA) Q60675 (/IDA) |
Basal lamina GO:0005605
A thin sheet of proteoglycans and glycoproteins, especially laminin, secreted by cells as an extracellular matrix.
|
3 | A0A1D5PP29 (/IDA) F1M614 (/IDA) Q60675 (/IDA) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
3 | P19137 (/IDA) P25391 (/IDA) Q60675 (/IDA) |
Basement membrane GO:0005604
A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
|
2 | P19137 (/ISO) Q60675 (/ISO) |
Laminin-1 complex GO:0005606
A laminin complex composed of alpha1, beta1 and gamma1 polypeptide chains.
|
2 | P19137 (/IDA) P25391 (/IDA) |
Proteinaceous extracellular matrix GO:0005578
A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus.
|
1 | P19137 (/IDA) |
Proteinaceous extracellular matrix GO:0005578
A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus.
|
1 | P25391 (/ISS) |
Basement membrane GO:0005604
A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
|
1 | P24043 (/TAS) |
Basal lamina GO:0005605
A thin sheet of proteoglycans and glycoproteins, especially laminin, secreted by cells as an extracellular matrix.
|
1 | P19137 (/TAS) |
Laminin-1 complex GO:0005606
A laminin complex composed of alpha1, beta1 and gamma1 polypeptide chains.
|
1 | P25391 (/IPI) |
Laminin-1 complex GO:0005606
A laminin complex composed of alpha1, beta1 and gamma1 polypeptide chains.
|
1 | P19137 (/ISO) |
Laminin-3 complex GO:0005608
A laminin complex composed of alpha1, beta2 and gamma1 polypeptide chains.
|
1 | P25391 (/IPI) |
Laminin-3 complex GO:0005608
A laminin complex composed of alpha1, beta2 and gamma1 polypeptide chains.
|
1 | P19137 (/ISO) |
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | P19137 (/ISO) |
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
|
1 | A0A1D5PP29 (/IDA) |
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
|
1 | P19137 (/IDA) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | P25391 (/IDA) |
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | P19137 (/ISO) |
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support for cells or tissues.
|
1 | P25391 (/IDA) |
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support for cells or tissues.
|
1 | P19137 (/ISO) |
Sarcolemma GO:0042383
The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers.
|
1 | Q60675 (/IDA) |
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
|
1 | F1M614 (/IDA) |
Laminin complex GO:0043256
A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha, beta and gamma. Provides an integral part of the structural scaffolding of basement membranes.
|
1 | P19137 (/IDA) |
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | P24043 (/IDA) |
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
|
1 | Q60675 (/ISO) |