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CATH Superfamily 1.20.59.10

Chorismate mutase

The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Chorismate mutase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2126: Chorismate mutase, clade 2

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Chorismate mutase. [EC: 5.4.99.5]
Chorismate = prephenate.
    		 180 A0A024HKQ4 A0A031IUQ7 A0A066ZVQ0 A0A072ZSH0 A0A083UQ31 A0A098FQ70 A0A0A1I470 A0A0A1Z604 A0A0A4GJK8 A0A0B1Z412
    (170 more...)
    Prephenate dehydratase. [EC: 4.2.1.51]
    Prephenate = phenylpyruvate + H(2)O + CO(2).
    • This enzyme in the enteric bacteria also possesses EC 5.4.99.5 activity and converts chorismate into prephenate.
    		 166 A0A031IUQ7 A0A061CR64 A0A072ZSH0 A0A098FQ70 A0A0A1I470 A0A0A1Z604 A0A0A4GJK8 A0A0A6DA81 A0A0A7PY65 A0A0B1Z412
    (156 more...)
    3-demethylubiquinol 3-O-methyltransferase. [EC: 2.1.1.64]
    S-adenosyl-L-methionine + 3-demethylubiquinone-n = S-adenosyl-L- homocysteine + ubiquinone-n.
    • This enzyme is involved in ubiquinone biosynthesis.
    • Ubiquinones from different organisms have a different number of prenyl units (for example, ubiquinone-6 in Saccharomyces, ubiquinone- 9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units.
    • However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units.
    • For example, the human COQ3 enzyme can restore biosynthesis of ubiquinone-6 in coq3 deletion mutants of yeast.
    • The enzymes from yeast, Escherichia coli and rat also catalyze the methylation of 3,4-dihydroxy-5-all-trans-polyprenylbenzoate (a reaction that is classified as EC 2.1.1.114).
    		 3 A0A0F4XRZ3 G8Q1R4 S6I609
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