CATH Domain 4a6dA01

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.10	Arc Repressor Mutant, subunit A
	1.10.10.10	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

Superfamily	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Functional Family	O-methyltransferase family protein, expressed

2.1.1.4

Acetylserotonin O-methyltransferase.

based on mapping to UniProt P46597

S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin.

-!- Some other hydroxyindoles also act as acceptor, more slowly.

ASMT_HUMAN

Homo sapiens

Acetylserotonin O-methyltransferase

PDB	4A6D
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal Structure and Functional Mapping of Human Asmt, the Last Enzyme of the Melatonin Synthesis Pathway. Botros, H.G., Legrand, P., Pagan, C., Bondet, V., Weber, P., Ben-Abdallah, M., Lemiere, N., Huguet, G., Bellalou, J., Maronde, E., Beguin, P., Haouz, A., Shepard, W., Bourgeron, T. J.Pineal Res.