CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.10 | Arc Repressor Mutant, subunit A |
|
1.10.10.10 | Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain |
Domain Context
CATH Clusters
| Superfamily | Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain |
| Functional Family | O-methyltransferase family protein, expressed |
Enzyme Information
| 2.1.1.4 |
Acetylserotonin O-methyltransferase.
based on mapping to UniProt P46597
S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin.
-!- Some other hydroxyindoles also act as acceptor, more slowly.
|
UniProtKB Entries (1)
| P46597 |
ASMT_HUMAN
Homo sapiens
Acetylserotonin O-methyltransferase
|
PDB Structure
| PDB | 4A6D |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal Structure and Functional Mapping of Human Asmt, the Last Enzyme of the Melatonin Synthesis Pathway.
J.Pineal Res.
|