CATH Domain 3gd7A01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.300	P-loop containing nucleotide triphosphate hydrolases

Domain Context

CATH Clusters

Superfamily	P-loop containing nucleotide triphosphate hydrolases
Functional Family	Multidrug resistance-associated ABC transporter

Enzyme Information

3.6.3.49	Channel-conductance-controlling ATPase. based on mapping to UniProt P13569 ATP + H(2)O = ADP + phosphate. -!- An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. -!- It is also involved in the functioning of other transmembrane channels.
3.6.3.19	Maltose-transporting ATPase. based on mapping to UniProt P68187 ATP + H(2)O + maltose(Out) = ADP + phosphate + maltose(In). -!- Comprises bacterial enzymes that import maltose and maltose oligosaccharides.

UniProtKB Entries (2)

P68187	MALK_ECOLI Escherichia coli K-12 Maltose/maltodextrin import ATP-binding protein MalK
P13569	CFTR_HUMAN Homo sapiens Cystic fibrosis transmembrane conductance regulator

PDB Structure

PDB	3GD7
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of human NBD2 complexed with N6-Phenylethyl-ATP (P-ATP) Atwell, S., Antonysamy, S., Guggino, W.B., Conners, K., Emtage, S., Gheyi, T., Hunt, J.F., Lewis, H.A., Lu, F., Sauder, J.M., Weber, P.C., Wetmore, D., Zhao, X. To be Published