CATH Domain 1j90A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.300	P-loop containing nucleotide triphosphate hydrolases

Domain Context

CATH Clusters

Superfamily	P-loop containing nucleotide triphosphate hydrolases
Functional Family	Thymidine kinase 2, mitochondrial

Enzyme Information

2.7.1.145	Deoxynucleoside kinase. based on mapping to UniProt Q9XZT6 ATP + a 2'-deoxyribonucleoside = ADP + a 2'-deoxyribonucleoside 5'-phosphate. -!- The enzyme from embryonic cells of the fruit fly Drosophila melanogaster differs from other 2'-deoxyribonucleoside kinases (EC 2.7.1.76 and EC 2.7.1.113) in its broad specificity for all four common 2'-deoxyribonucleosides.
2.7.1.21	Thymidine kinase. based on mapping to UniProt Q9XZT6 ATP + thymidine = ADP + thymidine 5'-phosphate. -!- Deoxyuridine can also act as acceptor. -!- dGTP can also act as donor. -!- The deoxypyrimidine kinase complex induced by Herpes simplex virus catalyzes this reaction as well as those of EC 2.7.1.114, EC 2.7.1.118, and EC 2.7.4.9. -!- Formerly EC 2.7.1.75.

UniProtKB Entries (1)

DNK_DROME

Drosophila melanogaster

Deoxynucleoside kinase

PDB Structure

PDB	1J90
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Structural basis for substrate specificities of cellular deoxyribonucleoside kinases. Johansson, K., Ramaswamy, S., Ljungcrantz, C., Knecht, W., Piskur, J., Munch-Petersen, B., Eriksson, S., Eklund, H. Nat.Struct.Biol.