CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.10 | Arc Repressor Mutant, subunit A |
|
1.10.10.10 | Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain |
Domain Context
CATH Clusters
| Superfamily | Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain |
| Functional Family | Methylated-DNA--protein-cysteine methyltransferase family protein |
Enzyme Information
| 2.1.1.63 |
Methylated-DNA--[protein]-cysteine S-methyltransferase.
based on mapping to UniProt P16455
DNA (containing 6-O-methylguanine) + protein L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine.
-!- This protein is involved in the repair of alkylated DNA. -!- It acts only on the alkylated DNA (cf. EC 3.2.2.20 and EC 3.2.2.21). -!- This enzyme catalyzes only one turnover and therefore is not strictly catalytic.
|
UniProtKB Entries (1)
| P16455 |
MGMT_HUMAN
Homo sapiens
Methylated-DNA--protein-cysteine methyltransferase
|
PDB Structure
| PDB | 1EH6 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding.
EMBO J.
|
