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CATH Superfamily 1.10.2000.10

Frizzled cysteine-rich domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Frizzled cysteine-rich domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
secreted frizzled-related protein 2
487 - - 93.8
2
Inactive tyrosine-protein kinase transmembrane receptor ROR1
381 - - 72.4
3
Frizzled class receptor 2
373
3D
 6o3bH00 - 72.1
4
Frizzled class receptor 8a
302
3D
 6o39C00 - 79.7
5
secreted frizzled-related protein 4
236
3D
 1ijxF00 - 86.8
6
Frizzled-3 protein
186 - - 75.4
7
Frizzled class receptor 10
185 - - 75.7
8
Frizzled receptor 4
177
3D
 6ne1A00 - 77.9
9
Muscle, skeletal, receptor tyrosine kinase
146
3D
 3hklB00 - 84.0
10
Smoothened, frizzled class receptor
141
3D
 5l7iB01 - 80.1
11
Corin, serine peptidase
128 - - 48.0
12
Carboxypeptidase Z
94 - - 84.8
13
atrial natriuretic peptide-converting enzyme
87 - - 52.6
14
frizzled-6 isoform X1
82 - - 74.7
15
membrane frizzled-related protein
62 - - 61.0
16
Frizzled
39 - - 87.9
17
Alpha 1 type XVIII collagen
27 - - 90.7
18
Tyrosine-protein kinase receptor
21 - - 47.4
19
Corin, isoform B
17 - - 77.7
21
Blast:Protein smoothened
15
3D
 2mahA00 - 40.9
20
Uncharacterized protein
15 - - 92.4
22
Smoothened, frizzled class receptor
14 - - 10.1
23
Tyrosine-protein kinase transmembrane receptor ROR2
12 - - 40.0
24
Transmembrane receptor LIN-17
10 - - 9.4
26
Tyrosine-protein kinase receptor cam-1
9 - - 9.8
25
Tyrosine-protein kinase receptor
9 - - 47.6
29
Predicted protein
8 - - 82.2
27
Transmembrane receptor
8 - - 11.9
28
8 - - 11.7
30
Uncharacterized protein
6 - - 90.7
32
Secreted frizzled-related protein precusor
5 - - 76.4
31
5 - - 23.4
33
5 - - 68.2
34
5 - - 79.6
35
AGAP000168-PA
4 - - 10.5
37
4 - - 71.2
36
Frizzled-3
4 - - 13.0
39
3 - - 1.6
40
3 - - 18.3
41
3 - - 0.0
38
3 - - 6.0
49
2 - - 40.1
43
2 - - 8.6
45
2 - - 0.0
42
2 - - 0.9
51
2 - - 0.0
48
2 - - 8.0
50
2 - - 0.0
53
2 - - 1.5
55
2 - - 40.7
47
2 - - 1.0
52
2 - - 0.0
46
2 - - 1.0
44
2 - - 0.0
54
2 - - 0.9
71
1 - - 0.0
84
1 - - 0.0
58
1 - - 0.0
76
1 - - 0.0
62
1 - - 0.0
61
1 - - 0.0
87
1 - - 0.0
77
1 - - 0.0
64
1 - - 0.0
78
1 - - 0.0
60
1 - - 0.0
82
1 - - 0.0
69
1 - - 0.0
79
1 - - 0.0
72
1 - - 0.0
85
1 - - 0.0
57
1 - - 0.0
73
1 - - 0.0
67
1 - - 0.0
74
1 - - 0.0
68
1 - - 0.0
83
1 - - 0.0
65
1 - - 0.0
81
1 - - 0.0
86
1 - - 0.0
63
1 - - 0.0
80
1 - - 0.0
56
1 - - 0.0
66
1 - - 0.0
70
1 - - 0.0
88
1 - - 0.0
75
1 - - 0.0
59
1 - - 0.0