CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Non-specific serine/threonine protein kinase

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt P31749
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P31749
AKT1_HUMAN
Homo sapiens
RAC-alpha serine/threonine-protein kinase

PDB Structure

PDB 6HHJ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt.
Uhlenbrock, N., Smith, S., Weisner, J., Landel, I., Lindemann, M., Le, T.A., Hardick, J., Gontla, R., Scheinpflug, R., Czodrowski, P., Janning, P., Depta, L., Quambusch, L., Muller, M.P., Engels, B., Rauh, D.
Chem Sci