CATH Classification
Domain Context
CATH Clusters
Superfamily | Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 4 |
Functional Family | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta |
Enzyme Information
2.7.1.153 |
Phosphatidylinositol-4,5-bisphosphate 3-kinase.
based on mapping to UniProt O35904
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.
-!- This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P(2), and of PtdIns to PtdIns3P.
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UniProtKB Entries (1)
O35904 |
PK3CD_MOUSE
Mus musculus
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
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PDB Structure
PDB | 5T8I |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
The Discovery of GS-9901: A Potent, Selective and Metabolically Stable Inhibitor of PI3Kd
To Be Published
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