CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.390 | Enolase-like; domain 1 |
|
3.30.390.30 | FAD/NAD-linked reductase, C-terminal dimerisation domain |
Domain Context
CATH Clusters
| Superfamily | 3.30.390.30 |
| Functional Family |
Enzyme Information
| 1.8.1.14 |
CoA-disulfide reductase.
based on mapping to UniProt O58308
2 CoA + NADP(+) = CoA-disulfide + NADPH.
-!- Not identical with EC 1.8.1.6, EC 1.8.1.7 or EC 1.8.1.13. -!- The enzyme from the bacterium Staphylococcus aureus has a strong preference for NADPH, while the bacterium Bacillus megaterium contains both NADH and NADPH-dependent enzymes. -!- Formerly EC 1.6.4.10.
|
UniProtKB Entries (1)
| O58308 |
CDR_PYRHO
Pyrococcus horikoshii OT3
Coenzyme A disulfide reductase
|
PDB Structure
| PDB | 5L1N |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
A broader active site inPyrococcus horikoshiiCoA disulfide reductase accommodates larger substrates and reveals evidence of subunit asymmetry.
FEBS Open Bio
|