CATH Domain 5g2nA03

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.25	Alpha Horseshoe
	1.25.40	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
	1.25.40.70	Phosphatidylinositol 3-kinase, accessory domain (PIK)

Domain Context

CATH Clusters

Superfamily	Phosphatidylinositol 3-kinase, accessory domain (PIK)
Functional Family	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Enzyme Information

2.7.1.153	Phosphatidylinositol-4,5-bisphosphate 3-kinase. based on mapping to UniProt P48736 ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate. -!- This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P(2), and of PtdIns to PtdIns3P.
2.7.11.1	Non-specific serine/threonine protein kinase. based on mapping to UniProt P48736 ATP + a protein = ADP + a phosphoprotein. -!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

PK3CG_HUMAN

Homo sapiens

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

PDB Structure

PDB	5G2N
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery and Sar of Novel 2,3-Dihydroimidazo(1,2-C)Quinazoline Pi3K Inhibitors: Identification of Copanlisib (Bay 80-6946) Schaefer, M., Scott, W.J., Hentemann, M.F., Rowley, R.B., Bull, C.O., Jenkins, S., Bullion, A.M., Johnson, J., Redman, A., Robbins, A.H., Esler, W., Fracasso, R.P., Garrison, T., Hamilton, M., Michels, M., Wood, J.E., Wilkie, D.P., Xiao, H., Levy, J., Liu, N., Stasik, E., Brands, M., Lefranc, J. Chemmedchem