CATH Domain 5a4kA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.360	Flavodoxin domain

Domain Context

CATH Clusters

Superfamily	3.40.50.360
Functional Family	NAD(P)H dehydrogenase [quinone] 1

Enzyme Information

1.6.5.2

NAD(P)H dehydrogenase (quinone).

based on mapping to UniProt P15559

NAD(P)H + a quinone = NAD(P)(+) + a hydroquinone.

-!- The enzyme catalyzes a two-electron reduction and has a preference for short-chain acceptor quinones, such as ubiquinone, benzoquinone, juglone and duroquinone. -!- The animal, but not the plant, form of the enzyme is inhibited by dicoumarol. -!- Formerly EC 1.6.99.2.

UniProtKB Entries (1)

P15559

NQO1_HUMAN

Homo sapiens

NAD(P)H dehydrogenase [quinone] 1

PDB Structure

PDB	5A4K
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Catalytic competence, structure and stability of the cancer-associated R139W variant of the human NAD(P)H:quinone oxidoreductase 1 (NQO1). Lienhart, W.D., Strandback, E., Gudipati, V., Koch, K., Binter, A., Uhl, M.K., Rantasa, D.M., Bourgeois, B., Madl, T., Zangger, K., Gruber, K., Macheroux, P. FEBS J.