CATH Domain 4uwlA01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.25	Alpha Horseshoe
	1.25.40	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
	1.25.40.70	Phosphatidylinositol 3-kinase, accessory domain (PIK)

Domain Context

CATH Clusters

Superfamily	Phosphatidylinositol 3-kinase, accessory domain (PIK)
Functional Family	Phosphatidylinositol 3-kinase catalytic subunit type 3

Enzyme Information

2.7.1.137

Phosphatidylinositol 3-kinase.

based on mapping to UniProt Q8NEB9

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo- inositol 3-phosphate.

UniProtKB Entries (1)

PK3C3_HUMAN

Homo sapiens

Phosphatidylinositol 3-kinase catalytic subunit type 3

PDB Structure

PDB	4UWL
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of (2S)-8-[(3R)-3-Methylmorpholin-4-Yl]-1-(3-Methyl-2-Oxo-Butyl)-2-(Trifluoromethyl)-3,4-Dihydro-2H-Pyrimido[1,2-A]Pyrimidin-6-One: A Novel Potent and Selective Inhibitor of Vps34 for the Treatment of Solid Tumors. Pasquier, B., El-Ahmad, Y., Filoche-Romme, B., Dureuil-Sizaire, C., Fassy, F., Abecassis, P., Mathieu, M., Bertrand, T., Benard, T., Barriere, C., El Batti, S., Letallec, J., Sonnefraud, V., Brollo, M., Delbarre, L., Loyau, V., Pilorge, F., Bertin, L., Richepin, P., Arigon, J., Labrosse, J., Clement, J., Durand, F., Combet, R., Perraut, P., Leroy, V., Gay, F., Lefrancois, D., Bretin, F., Marquette, J., Michot, N., Caron, A., Castell, C., Schio, L., Mccort, G., Goulaouic, H., Garcia-Echeverria, C., Ronan, B.P. J.Med.Chem.