CATH Domain 4ibgA02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.10	Ribbon
	2.10.10	Seminal Fluid Protein PDC-109 (Domain B)
	2.10.10.70	Filoviridae VP35, C-terminal inhibitory domain, beta-sheet subdomain

Domain Context

CATH Clusters

Superfamily	Filoviridae VP35, C-terminal inhibitory domain, beta-sheet subdomain
Functional Family	Polymerase cofactor VP35

Enzyme Information

UniProtKB Entries (1)

VP35_EBOZM

Ebola virus - Mayinga, Zaire, 1976

Polymerase cofactor VP35

PDB Structure

PDB	4IBG
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity. Brown, C.S., Lee, M.S., Leung, D.W., Wang, T., Xu, W., Luthra, P., Anantpadma, M., Shabman, R.S., Melito, L.M., Macmillan, K.S., Borek, D.M., Otwinowski, Z., Ramanan, P., Stubbs, A.J., Peterson, D.S., Binning, J.M., Tonelli, M., Olson, M.A., Davey, R.A., Ready, J.M., Basler, C.F., Amarasinghe, G.K. J.Mol.Biol.