CATH Domain 4ibcA01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.8	Helicase, Ruva Protein; domain 3
	1.10.8.950	Filoviridae VP35, C-terminal inhibitory domain, helical subdomain

Domain Context

CATH Clusters

Superfamily	Filoviridae VP35, C-terminal inhibitory domain, helical subdomain
Functional Family	Polymerase cofactor VP35

Enzyme Information

UniProtKB Entries (1)

VP35_EBOZM

Ebola virus - Mayinga, Zaire, 1976

Polymerase cofactor VP35

PDB Structure

PDB	4IBC
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity. Brown, C.S., Lee, M.S., Leung, D.W., Wang, T., Xu, W., Luthra, P., Anantpadma, M., Shabman, R.S., Melito, L.M., Macmillan, K.S., Borek, D.M., Otwinowski, Z., Ramanan, P., Stubbs, A.J., Peterson, D.S., Binning, J.M., Tonelli, M., Olson, M.A., Davey, R.A., Ready, J.M., Basler, C.F., Amarasinghe, G.K. J.Mol.Biol.