1 keywords

CATH Domain 4ajwA03

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.25 Alpha Horseshoe
Topology 1.25.40 Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Homologous Superfamily 1.25.40.70 Phosphatidylinositol 3-kinase, accessory domain (PIK)

Domain Context

CATH Clusters

Superfamily Phosphatidylinositol 3-kinase, accessory domain (PIK)
Functional Family

Enzyme Information

2.7.1.153
Phosphatidylinositol-4,5-bisphosphate 3-kinase.
based on mapping to UniProt O35904
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate.
-!- This enzyme also catalyzes the phosphorylation of PtdIns4P to PtdIns(3,4)P(2), and of PtdIns to PtdIns3P.

UniProtKB Entries (1)

O35904
PK3CD_MOUSE
Mus musculus
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

PDB Structure

PDB 4AJW
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery and Optimization of New Benzimidazole- and Benzoxazole-Pyrimidone Selective Pi3Kbeta Inhibitors for the Treatment of Phosphatase and Tensin Homologue (Pten)-Deficient Cancers.
Certal, V., Halley, F., Virone-Oddos, A., Delorme, C., Karlsson, A., Rak, A., Thompson, F., Filoche-Romm, B., El-Ahmad, Y., Carry, J.C., Abecassis, P.Y., Lejeune, P., Vincent, L., Bonnevaux, H., Nicolas, J.P., Bertrand, T., Marquette, J.P., Michot, N., Benard, T., Below, P., Vade, I., Chatreaux, F., Lebourg, G., Pilorge, F., Angouillant-Boniface, O., Louboutin, A., Lengauer, C., Schio, L.
J.Med.Chem.