CATH Domain 3ojxA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.360	Flavodoxin domain

Domain Context

CATH Clusters

Superfamily	3.40.50.360
Functional Family	NADPH--cytochrome P450 reductase

Enzyme Information

1.6.2.4

NADPH--hemoprotein reductase.

based on mapping to UniProt P00388

NADPH + n oxidized hemoprotein = NADP(+) + n reduced hemoprotein.

-!- This enzyme catalyzes the transfer of electrons from NADPH, an obligatory two-electron donor, to microsomal P450 monooxygenases (e.g. EC 1.14.14.1) by stabilizing the one-electron reduced form of the flavin cofactors FAD and FMN. -!- It also reduces cytochrome b5 and cytochrome c. -!- The number n in the equation is 1 if the hemoprotein undergoes a 2-electron reduction, and is 2 if it undergoes a 1-electron reduction.

UniProtKB Entries (1)

P00388

NCPR_RAT

Rattus norvegicus

NADPH--cytochrome P450 reductase

PDB Structure

PDB	3OJX
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Conformational Changes of NADPH-Cytochrome P450 Oxidoreductase Are Essential for Catalysis and Cofactor Binding. Xia, C., Hamdane, D., Shen, A.L., Choi, V., Kasper, C.B., Pearl, N.M., Zhang, H., Im, S.C., Waskell, L., Kim, J.J. J.Biol.Chem.