CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.12580 | CDP-glycerol glycerophosphotransferase, C-terminal domain |
Domain Context
CATH Clusters
| Superfamily | 3.40.50.12580 |
| Functional Family |
Enzyme Information
| 2.7.8.12 |
Teichoic acid poly(glycerol phosphate) polymerase.
based on mapping to UniProt Q5HLM5
n CDP-glycerol + 4-O-((2R)-glycerophospho)-N-acetyl-beta-D-mannosaminyl- (1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis- undecaprenol = n CMP + 4-O-(((2R)-glycerophospho)n-(2R)-glycerophospho)- N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl- diphospho-ditrans,octacis-undecaprenol.
-!- Involved in the biosynthesis of poly glycerol phosphate teichoic acids in bacterial cell walls. -!- This enzyme adds 30-50 glycerol units to the linker molecule, but only after it has been primed with the first glycerol unit by EC 2.7.8.44. -!- Cf. EC 2.7.8.45.
|
UniProtKB Entries (1)
| Q5HLM5 |
TAGF_STAEQ
Staphylococcus epidermidis RP62A
Teichoic acid poly(glycerol phosphate) polymerase
|
PDB Structure
| PDB | 3L7M |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure of the bacterial teichoic acid polymerase TagF provides insights into membrane association and catalysis.
Nat.Struct.Mol.Biol.
|
