CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.40 | 3-Layer(aba) Sandwich |
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3.40.50 | Rossmann fold |
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3.40.50.12580 | CDP-glycerol glycerophosphotransferase, C-terminal domain |
Domain Context
CATH Clusters
Superfamily | 3.40.50.12580 |
Functional Family |
Enzyme Information
2.7.8.12 |
Teichoic acid poly(glycerol phosphate) polymerase.
based on mapping to UniProt Q5HLM5
n CDP-glycerol + 4-O-((2R)-glycerophospho)-N-acetyl-beta-D-mannosaminyl- (1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis- undecaprenol = n CMP + 4-O-(((2R)-glycerophospho)n-(2R)-glycerophospho)- N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl- diphospho-ditrans,octacis-undecaprenol.
-!- Involved in the biosynthesis of poly glycerol phosphate teichoic acids in bacterial cell walls. -!- This enzyme adds 30-50 glycerol units to the linker molecule, but only after it has been primed with the first glycerol unit by EC 2.7.8.44. -!- Cf. EC 2.7.8.45.
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UniProtKB Entries (1)
Q5HLM5 |
TAGF_STAEQ
Staphylococcus epidermidis RP62A
Teichoic acid poly(glycerol phosphate) polymerase
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PDB Structure
PDB | 3L7J |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structure of the bacterial teichoic acid polymerase TagF provides insights into membrane association and catalysis.
Nat.Struct.Mol.Biol.
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