CATH Domain 3l25A01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.8	Helicase, Ruva Protein; domain 3
	1.10.8.950	Filoviridae VP35, C-terminal inhibitory domain, helical subdomain

Domain Context

CATH Clusters

Superfamily	Filoviridae VP35, C-terminal inhibitory domain, helical subdomain
Functional Family	Polymerase cofactor VP35

Enzyme Information

UniProtKB Entries (1)

VP35_EBOZM

Ebola virus - Mayinga, Zaire, 1976

Polymerase cofactor VP35

PDB Structure

PDB	3L25
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35. Leung, D.W., Prins, K.C., Borek, D.M., Farahbakhsh, M., Tufariello, J.M., Ramanan, P., Nix, J.C., Helgeson, L.A., Otwinowski, Z., Honzatko, R.B., Basler, C.F., Amarasinghe, G.K. Nat.Struct.Mol.Biol.