CATH Classification

Domain Context

CATH Clusters

Superfamily 3.60.21.10
Functional Family Serine/threonine-protein phosphatase

Enzyme Information

3.1.3.16
Protein-serine/threonine phosphatase.
based on mapping to UniProt P62136
[a protein]-serine/threonine phosphate + H(2)O = [a protein]- serine/threonine + phosphate.
-!- A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48). -!- The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1).

UniProtKB Entries (2)

O35274
NEB2_RAT
Rattus norvegicus
Neurabin-2
P62136
PP1A_HUMAN
Homo sapiens
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

PDB Structure

PDB 3EGG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites.
Ragusa, M.J., Dancheck, B., Critton, D.A., Nairn, A.C., Page, R., Peti, W.
Nat.Struct.Mol.Biol.