CATH Domain 3dgvA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.630	Aminopeptidase
	3.40.630.10	Zn peptidases

Domain Context

CATH Clusters

Superfamily	Zn peptidases
Functional Family	Carboxypeptidase B2

Enzyme Information

3.4.17.20

Carboxypeptidase U.

based on mapping to UniProt Q2KIG3

Release of C-terminal Arg and Lys from a polypeptide.

-!- Pro-carboxypeptidase U in plasma is activated by thrombin or plasmin during clotting to form the unstable carboxypeptidase U. -!- Activity similar to that of the more stable lysine carboxypeptidase, except no preference is shown for Lys over Arg. -!- Belongs to peptidase family M14.

UniProtKB Entries (1)

Q2KIG3

CBPB2_BOVIN

Bos taurus

Carboxypeptidase B2

PDB Structure

PDB	3DGV
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The crystal structure of TAFI provides the structural basis for the intrinsic activity of the proenzyme and short half-life of TAFIa Anand, K., Pallares, I., Valnickova, Z., Christensen, T., Vendrell, J., Wendt, K.U., Schreuder, H.A., Enghild, J.J., Avil S, F.X. To be Published

Network disruptions