CATH Classification
Level | CATH Code | Description |
---|---|---|
2 | Mainly Beta | |
2.40 | Beta Barrel | |
2.40.50 | OB fold (Dihydrolipoamide Acetyltransferase, E2P) | |
2.40.50.150 | RNA polymerase II, Rpb2 subunit, wall domain |
Domain Context
CATH Clusters
Superfamily | 2.40.50.150 |
Functional Family | DNA-directed RNA polymerase subunit beta |
Enzyme Information
2.7.7.6 |
DNA-directed RNA polymerase.
based on mapping to UniProt P08518
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.
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UniProtKB Entries (1)
P20433 |
RPB4_YEAST
Saccharomyces cerevisiae S288C
DNA-directed RNA polymerase II subunit RPB4
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PDB Structure
PDB | 2JA6 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
CPD damage recognition by transcribing RNA polymerase II.
Science
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